COBRE Center for Molecular and Tumor Virology

COBRE 分子和肿瘤病毒学中心

• 批准号: 8702334
• 负责人: DENNIS John O'CALLAGHAN
• 金额: $ 97.44万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702334
• 关键词: Address; Advisory Committees; Animals; Antiviral Agents; Bioinformatics; Cancer Center; Cardiovascular Diseases; Cell physiology; Centers of Research Excellence; Core Facility; DNA Sequencing Facility; Development; Disease; Effectiveness; Epigenetic Process; Equipment; Faculty; Fostering; Funding; Future; Genomic DNA; Genomics; Goals; Grant; Health; Health Sciences; Human; Immune system; Immunology; Induced Mutation; Interdisciplinary Study; Journals; Louisiana; Malignant Neoplasms; Mentors; Methods; Mission; Molecular; Molecular Analysis; Monitor; Mutation; Nursing Faculty; Phase; Pilot Projects; Play; Postdoctoral Fellow; Principal Investigator; Productivity; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Role; Science; Scientist; Services; Structure; Students; Surveys; Technology; Training and Education; Translational Research; Tumor Tissue; Universities; Virus; Virus Diseases; Visit; Writing; cell transformation; college; combat; design; meetings; member; neoplastic cell; new technology; next generation sequencing; novel vaccines; operation; outreach; pathogen; prevent; programs; public health relevance; symposium; tumor; tumorigenesis; virology

: COBRE Center for Molecular and Tumor Virology ABSTRACT The Center for Molecular and Tumor Virology (CMTV) located at the Louisiana State University Health Sciences Center-Shreveport, University of Louisiana at Monroe, and Louisiana State University-Shreveport in north Louisiana seeks continued support via the COBRE Phase III Program. The multi-institutional CMTV is comprised of 18 faculty members who investigate the structure, genomics, bioinformatics, replication, immunology, and oncogenesis of important animal and human pathogens and their impact on health. The overall objective of this application is to maintain and expand the expertise, mission, and quality of four CMTV Core Facilities that contribute to the research competitiveness of CMTV investigators. The Cores contribute to the ongoing research of the faculty, fellows, and students both within and outside the Center. The research design is multifunctional and will: 1. provide an ongoing Mentoring Program to foster the development of junior and mid-level faculty members who will become competitive for national funding. The methods for mentoring include daily interactions at the bench, CMTV weekly journal club and seminars, a fortnightly research conference of all CMTV members, quarterly meetings of the Mentoring Committee and Internal Advisors to advise junior faculty and assess their progress, interactions with national leaders in virology who will serve as Visiting Scientists, and a yearly Virology Colloquium that includes visits and advice of the External Advisors. 2. promote interdisciplinary and translational research that will expand research at all three campuses and contribute to the productivity of all investigators; A Research Pilot Project Program supplemented by institutional funds will expand and encourage new collaborative research and foster translational and interdisciplinary projects. 3. maintain and manage four Core Facilities that offer equipment, expertise, and state-of-the-art technologies required to address fundamental questions about mechanisms by which viruses replicate, alter the host, and cause disease including cancer. Plans to provide for the operation and support of the CMTV Cores after Phase III are being made, and plans will be implemented to assure that the mission of the CMTV is ongoing after five years of COBRE Phase III funding. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): O’Callaghan, Dennis J. Modified Specific Aims

COBRE分子和肿瘤病毒学中心 摘要 位于路易斯安那州立大学卫生部的分子和肿瘤病毒学中心（CMTV） 科学中心什里夫波特，路易斯安那大学门罗，路易斯安那州立大学什里夫波特， 北路易斯安那州通过COBRE第三阶段计划寻求持续的支持。多机构CMTV是 由18名研究结构、基因组学、生物信息学、复制 免疫学、重要动物和人类病原体的肿瘤发生及其对健康的影响。的 该应用程序的总体目标是保持和扩展四个CMTV的专业知识、使命和质量 核心设施，有助于CMTV研究人员的研究竞争力。核心有助于 正在进行的研究的教师，研究员和学生内外的中心。研究 设计是多功能的，将：1。提供一个持续的指导计划，以促进发展的初级 和中级教师谁将成为国家资金的竞争力。指导方法 包括在板凳上的日常互动，CMTV周刊俱乐部和研讨会，每两周一次的研究 所有CMTV成员会议，指导委员会和内部顾问季度会议， 建议初级教师和评估他们的进展，与国家领导人在病毒学谁将担任互动 访问科学家，以及每年一次的病毒学讨论会，其中包括外部顾问的访问和建议。2. 促进跨学科和转化研究，这将扩大所有三个校区的研究， 有助于所有研究者的生产力;一个研究试点项目计划， 机构资金将扩大和鼓励新的合作研究，并促进转化和 跨学科项目。3.维护和管理四个核心设施，提供设备，专业知识， 解决有关病毒传播机制的基本问题所需的最新技术 复制，改变宿主，并导致疾病，包括癌症。计划提供运营和支持 正在制定第三阶段后的CMTV核心，并将实施计划，以确保 CMTV是在COBRE第三阶段资助五年后进行的。 OMB编号0925-0001/0002（2012年8月批准至2015年8月31日修订版）页码续页格式页码 项目负责人/主要研究者（最后，第一，中间）：O 'Callaghan，Dennis J. Modified Specific Aims