COBRE Center for Molecular and Tumor Virology

描述（由申请人提供）：作为生命系统的天然探针，病毒为基本生物学过程提供了一些最基本的见解：DNA复制、转录和翻译、细胞信号传导途径、癌基因和肿瘤抑制因子以及宿主免疫防御。它们作为生物战和新兴传染病的重要性，以及它们在分子医学时代作为新疗法的潜力，为2003年路易斯安那州立大学健康科学中心什里夫波特的分子和肿瘤病毒学中心（CMTV）的创建提供了动力。经过四年的COBRE支持，我们在一个没有强大研究传统的机构中为世界级病毒学中心奠定了基础。CMTV是通过积极的教师招聘，年轻研究人员的勤奋指导，广泛的合作伙伴关系来创建可持续的研究基础设施，以及将COBRE目标与新制定的 大学长期研究发展战略计划。随着CMTV现在提供一个 力量的元素，可用于提高整体研究使命校园范围内，我们 建议通过以下方式扩大所请求的COBRE支持的影响：1）扩大CMTV 超越其原有的单一部门基础，以创造协同科学合作， 跨学科，促进研究成果的临床应用，并让三所大学参与， 北路易斯安那州和整合COBRE和INBRE计划; 2）指导开发 之前由COBRE资助的调查人员，以及对五名新项目领导人的支持 其多学科研究通过一个共同的主题相互联系， 病毒发病机理的基础; 3）通过创建COBRE加强研究基础设施 与现有共享服务完全集成和/或互补的核心。连同 实质性的大学承诺振兴使命，包括生物医学研究，这 CMTV开发的最后阶段将创建一个中心， COBRE倡议和NIH路线图，植根于优秀的基础科学研究， 翻译的重点，有利于应用假设驱动的调查，从板凳， 床头和后背

DESCRIPTION (provided by applicant): As natural probes of living systems, viruses have provided some of the most fundamental insights into basic biological processes: DNA replication, transcription and translation, cell signaling pathways, oncogenes and tumor suppressors, and host immune defense. Their importance as agents of biowarfare and emerging infectious diseases, together with their potential for use as novel therapeutics in an age of molecular medicine, provided the impetus for the creation of the Center of Molecular and Tumor Virology (CMTV) at Louisiana State University Health Sciences Center-Shreveport in 2003. After four years of COBRE support we have laid the foundation for a world class virology center at an institution without a strong research tradition. The CMTV was built by aggressive faculty recruitment, diligent mentoring of young investigators, extensive partnering to create a sustainable research infrastructure, and melding COBRE goals with a newly formulated University strategic plan for long-range research development. With the CMTV now providing an element of strength that can be used to enhance the overall research mission campus-wide, we propose to broaden the impact of the requested COBRE support by 1) expansion of the CMTV beyond its original single departmental base to create synergistic scientific collaborations that are interdisciplinary, promote clinical applications of research findings, and involve three universities in North Louisiana and integrate COBRE and INBRE programs; 2) mentored development of investigators previously funded by the COBRE, together with backing for five new Project Leaders whose multidisciplinary research is interconnected by a shared theme addressing the molecular basis for viral pathogenesis; 3) enhancement of research infrastructure by the creation of COBRE Cores that fully integrate with and/or complement existing shared services. Together with the substantive University commitment to a revitalized mission that embraces biomedical research, this final phase of CMTV development will create a Center that is responsive to overall goals of the COBRE initiative and NIH Roadmap and is rooted in excellent basic science investigation with a translational emphasis that favors application of hypothesis-driven investigation from bench to bedside and back.