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PROJECT 2: TRANSLATIONAL REGULATION OF THE MEIOTIC CELL CYCLE IN THE MALE.

项目 2：男性减数分裂细胞周期的翻译调控。

基本信息

批准号：
8638813
负责人：
MARGARET T FULLER
金额：
$ 33.1万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8638813
关键词：
3&apos Untranslated Regions B-Lymphocytes Binding Biological Models Cell Cycle Cell Cycle Progression Cell Cycle Regulation Cell Differentiation process Cells Chromosomes Cis-Acting Sequence Collaborations Cyclin B DNA biosynthesis Development Drosophila genus Embryo Embryonic Development Eukaryota Event Family Family member G2 Phase G2/M Transition Gametogenesis Gene Expression Genetic Germ Cells Heterogeneous-Nuclear Ribonucleoproteins Homologous Gene Homologous Protein Human Hybrids In Vitro Infertility Maps Meiosis Molecular Molecular Analysis Oocytes Oogenesis Organism Play Poly(A)-Binding Proteins Polyadenylation Production Prophase Proteins RNA RNA Cap-Binding Proteins RNA-Binding Proteins Recruitment Activity Regulation Reproduction Reproductive Biology Role Specific qualifier value Spermatocytes Spermatogenesis Spermiogenesis Staging Synapses Testing Time Transcript Translational Regulation Translational Repression Translations Universities Work Yeasts base cdc25 Phosphatase cell type design egg gene discovery insight male men oocyte maturation premature prevent programs sex stem cell biology

项目摘要

Meiosis is the signature event of the germ cell developmental program, absolutely required for sexual reproduction eukaryotes. Proper regulation of meiotic progression is crucial for production of functional gametes. A key aspect of meiosis is a germ cell specific cell cycle, in which a final round of DNA synthesis (premeiotic S) is followed by a greatly extended G2, termed meiotic prophase, prior to the two meiotic divisions. This signature cell cycle delay provides critical time for homologous chromosomes to pair, synapse and recombine, as well as for major biosynthetic events that drive gamete differentiation. In oocytes, the transcriptional, translational and morphogenetic changes that produce the egg and prepare for early embryogenesis are largely accomplished during meiotic prophase. In male germ cells, although dramatic morphological changes that produce mature gametes occur after the meiotic divisions, a major part of the gene expression program that sets up spermiogenesis takes place during meiotic prophase. In both sexes, meiotic onset, progression, maturation, and activation of the meiotic divisions are key regulatory points. Understanding how these events are regulated is key for understanding the molecular basis of meiotic arrest infertility, for designing effective strategies for differentiating germ cells from embryonic precursors, and for developing and maturing competent gametes in vitro. The analysis proposed in this subproject of the U54 Cooperative Center for Reproductive and Stem Cell Biology will elucidate fundamental mechanisms that control the cell cycle for meiotic prophase, including the critical control circuits that first pause the cell cycle, then finally activate the G2/M transition for meiosis I once proper expression of the program for gametogenesis has been achieved.

减数分裂是生殖细胞发育过程中的标志性事件，绝对是有性生殖所必需的