Incremental effect of smoking on HIV immune activation and cardiac health
Incremental effect of smoking on HIV immune activation and cardiac health
批准号:
8915891
负责人:
GRACE A MCCOMSEY
金额:
$78.84万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-15 至 2016-08-31
关键词:
AIDS preventionAcquired Immunodeficiency SyndromeAffectAgeAttenuatedBackBacteriaBehavior TherapyBlood VesselsCD4 Lymphocyte CountCardiacCardiovascular DiseasesCardiovascular systemCenters for Disease Control and Prevention (U.S.)ClinicalComorbidityDiabetes MellitusDiseaseEpidemiologic StudiesEventFrequenciesFundingFusobacteriumGeneral PopulationHIVHIV InfectionsHealthHeart DiseasesImageImmunologyIndividualInflammationInflammatoryInflammatory ResponseInterventionLifeLinkLongitudinal StudiesLymphocyteMalignant NeoplasmsMeasuresMediatingMediationMetabolicOralOral mucous membrane structureOrganismOsteoporosisOutcomeOxidative StressPathway interactionsPersonsPopulationPopulation StudyPorphyromonasReportingResearchRiskRisk ReductionSmokeSmokerSmokingSmoking StatusTimeTranslatingUnited States National Institutes of Healthantiretroviral therapyarterial stiffnesscardiovascular disorder riskcardiovascular risk factorendothelial dysfunctionfungusheart disease riskhigh riskimmune activationimprovedindexinginflammatory markermonocytemortalitynon-smokeroral bacteriaoral microbiomepathogenic bacteriasexsmoking cessationsmoking prevalencevascular inflammationyears of life lost
中文摘要
英文摘要
DESCRIPTION (provided by applicant): The prevalence of smoking is increased in the HIV-infected population. Active smoking is independently associated with higher risk of cardiovascular disease and other co-morbidities including malignancies and osteoporosis in HIV. However, the independent contribution of smoking to the heightened inflammation, immune activation, and cardiovascular risk remains unclear. We recently showed that smoking status is independently associated with increased levels of several inflammatory markers, and that higher inflammatory markers are associated with cardiovascular risk, diabetes and AIDS or non-AIDS clinical events in subjects receiving antiretroviral therapy. This application gathers a superb group of experts in HIV disease, vascular inflammation, immunology, vascular imaging, behavioral interventions, and oral microbiome studies to determine whether smoking status and furthermore smoking cessation, affect cardiovascular disease risk in HIV and the mediation effect of heightened inflammation, immune activation, oxidative stress and oral microbiome changes. Understanding the specific contribution of smoking to the heightened inflammation and immune activation in HIV-infected subjects on antiretroviral therapy has the potential to have a significant impact on prevention of HIV co-morbidities including cardiovascular disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)
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批准号:10704417
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项目类别:
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资助金额:$807.81万
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财政年份:2023
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负责人:GRACE A MCCOMSEY
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依托单位:
Clinical and Translational Science Collaborative of Cleveland
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批准号:10152707
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项目类别:
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资助金额:$593.37万
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财政年份:2018
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负责人:GRACE A MCCOMSEY
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依托单位:
Clinical and Translational Science Collaborative of Cleveland
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批准号:10400700
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项目类别:
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资助金额:$597.34万
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财政年份:2018
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负责人:GRACE A MCCOMSEY
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依托单位:
Role of Zinc in HIV inflammation
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批准号:9119326
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项目类别:
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资助金额:$22.61万
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财政年份:2016
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负责人:GRACE A MCCOMSEY
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依托单位:
Role of Zinc in HIV inflammation
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批准号:9333233
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项目类别:
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资助金额:$21.48万
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财政年份:2016
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负责人:GRACE A MCCOMSEY
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依托单位:
Role of Zinc in HIV inflammation
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批准号:9902711
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项目类别:
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资助金额:$24.14万
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财政年份:2016
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负责人:GRACE A MCCOMSEY
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依托单位:
Role of Zinc in HIV inflammation
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批准号:10227922
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项目类别:
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资助金额:$24.28万
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财政年份:2016
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负责人:GRACE A MCCOMSEY
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依托单位:
Vitamin D, drug metabolism, and cardiovascular complications in pediatric HIV
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批准号:8196123
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项目类别:
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资助金额:$35.68万
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财政年份:2011
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负责人:GRACE A MCCOMSEY
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依托单位:
Vitamin D, drug metabolism, and cardiovascular complications in pediatric HIV
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批准号:8511762
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项目类别:
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资助金额:$31.71万
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财政年份:2011
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负责人:GRACE A MCCOMSEY
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依托单位:
Vitamin D, drug metabolism, and cardiovascular complications in pediatric HIV
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批准号:8898162
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项目类别:
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资助金额:$32.32万
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财政年份:2011
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负责人:GRACE A MCCOMSEY
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依托单位:
Vitamin D, drug metabolism, and cardiovascular complications in pediatric HIV
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批准号:8705553
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项目类别:
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资助金额:$32.36万
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财政年份:2011
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负责人:GRACE A MCCOMSEY
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依托单位:
Vitamin D, drug metabolism, and cardiovascular complications in pediatric HIV
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批准号:8307782
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项目类别:
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资助金额:$33.43万
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财政年份:2011
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负责人:GRACE A MCCOMSEY
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依托单位:
Inflammation, Heart and Bone
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批准号:8289334
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项目类别:
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资助金额:$51.4万
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财政年份:2010
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负责人:GRACE A MCCOMSEY
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依托单位:
Inflammation, Heart and Bone
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批准号:8490199
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项目类别:
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资助金额:$47.46万
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财政年份:2010
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负责人:GRACE A MCCOMSEY
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依托单位:
Inflammation, Heart and Bone
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批准号:8150970
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项目类别:
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资助金额:$51.69万
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财政年份:2010
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负责人:GRACE A MCCOMSEY
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依托单位:
Inflammation, Heart and Bone
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批准号:8069727
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项目类别:
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资助金额:$53.32万
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财政年份:2010
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负责人:GRACE A MCCOMSEY
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依托单位:
Inflammation, Heart and Bone
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批准号:8668782
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项目类别:
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资助金额:$47.79万
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财政年份:2010
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负责人:GRACE A MCCOMSEY
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依托单位:
Metabolic Consequences of Thymidine Sparing Regimens
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批准号:7332256
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项目类别:
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资助金额:$21.27万
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财政年份:2006
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负责人:GRACE A MCCOMSEY
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依托单位:
Metabolic Consequences of Thymidine Sparing Regimens
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批准号:7167149
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项目类别:
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资助金额:$21.23万
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财政年份:2006
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负责人:GRACE A MCCOMSEY
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依托单位:
Metabolic Consequences of Thymidine Sparing Regimens
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批准号:7751264
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项目类别:
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资助金额:$17.15万
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财政年份:2006
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负责人:GRACE A MCCOMSEY
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依托单位:
海外基金