Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)

项目摘要/摘要 在过去的15年里，凯斯西部保护区的临床与翻译科学合作(CTSC) 大学(CWRU)将五个独立机构的临床和转化研究工作联系起来- CWRU、克利夫兰诊所、MetroHealth系统、克利夫兰大学医院和Louis Stokes克利夫兰 退伍军人事务医疗中心。两个新的合作伙伴(托莱多大学医学院和东北大学 现在正在增加)，以扩大CTSC的覆盖范围，覆盖整个俄亥俄州北部。CWRU CTSC在提高临床和翻译科学的数量和质量方面有着良好的记录 (CTS)通过促进新的研究范式、技术和培训在我们的合作伙伴中传播。我们的CTSC有 开发了新一代研究人员，加强了调查人员之间的协作，简化了 通过在行业、社区和组织合作伙伴之间建立伙伴关系进行发现，并促进 许多成功的创业公司。在此坚实基础上，CWRU CTSC提出了一个 扩大对卫生公平的关注，反映在项目主题催化与卫生公平的联系(CLE) 健康)。社会、经济和环境方面的劣势与不良的健康结果有关，并导致 预期寿命、婴儿死亡率和慢性病发病率方面的差异。少数群体往往是 在临床试验中也没有得到充分的代表，这意味着可能没有足够的数据来理解 针对不同人群的新药、程序或卫生干预措施的有效性或安全性。整体而言 本项目的目标是：1)了解最佳招聘人数不足的根本障碍 旨在打破这些障碍以实现多样化的临床试验、测试和规模干预的小组 研究参与度，2)通过以下方式促进和加快多中心临床和转化性研究的创新 充分整合社区和利益相关者合作伙伴，并确保本研究代表 所有人的经验和结果，以改善所有人的健康；3)传播和实施新颖和 跨临床和社区环境的响应性研究计划，以促进获得健康 旨在促进卫生公平的干预措施，以及4)创造和传播包容性和高影响力 为所有学科和水平的翻译研究专业人员提供教育和培训方案 临床和社区环境。CTSC设计了一个战略管理核心和六个CTS研究 实现这些目标的培训要素：劳动力发展、社区和利益相关者 参与、资源与服务、CTS试点、健康信息学和CTS研究计划。我们是 致力于创新和协作的实践和成果的传播，让北方的每个人 俄亥俄州和其他地区可以从我们的计划和发现中CTS的进步中受益。

PROJECT SUMMARY/ABSTRACT For the past 15 years, the Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University (CWRU) has linked clinical and translational research efforts at five independent institutions— CWRU, Cleveland Clinic, MetroHealth System, University Hospitals of Cleveland, and Louis Stokes Cleveland Veterans Affairs Medical Center. Two new partners (University of Toledo School of Medicine and Northeast Ohio Medical University) are now being added to extend the CTSC’s reach across Northern Ohio. The CWRU CTSC has a strong track record of enhancing the quantity and quality of Clinical and Translational Science (CTS) among our partners by facilitating novel research paradigms, technologies, and training. Our CTSC has developed a new generation of researchers, enhanced collaborations among investigators, streamlined discovery by building partnerships among industry and community and organizational partners, and facilitated many successful entrepreneurial startups. Building on this solid foundation, the CWRU CTSC proposes an expanded focus on health equity, reflected in the project theme Catalyzing Linkages to Equity in Health (CLE Health). Social, economic, and environmental disadvantages are linked to poor health outcomes and lead to disparities in life expectancy, infant mortality, and rates of chronic conditions. Minority groups are often underrepresented in clinical trials as well, meaning there can be insufficient data for understanding the effectiveness or safety of new drugs, procedures, or health interventions for different populations. The overall goals of this project are to 1) understand the fundamental barriers to optimal recruitment of underrepresented groups in clinical trials and test and scale interventions aimed at breaking down these barriers to diversify study engagement, 2) facilitate and expedite innovation in multicenter clinical and translational research by fully integrating community and stakeholder partners and ensuring that this research represents the experiences of all and results in health improvements for all, 3) disseminate and implement novel and responsive research programs across clinical and community settings to advance access to health interventions that aim to promote health equity, and 4) create and disseminate inclusive and high impact educational and training programs for translational research professionals of all disciplines and levels, both in clinical and community settings. The CTSC has designed a Strategic Management Core and six CTS research and training Elements to accomplish these goals: Workforce Development, Community & Stakeholder Engagement, Resources & Services, CTS Pilot, Health Informatics, and CTS Research Program. We are committed to innovative and collaborative practice and dissemination of results so that everyone in Northern Ohio—and beyond—can benefit from advances in CTS in our programs and discoveries.