Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)

北俄亥俄州临床和转化科学合作组织，促进健康公平的联系 (CLE Health)

• 批准号: 10704417
• 负责人: GRACE A MCCOMSEY
• 金额: $ 807.81万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-02 至 2030-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704417
• 关键词: Academia; Acceleration; Address; African American population; Appointment; Award; Chronic; Chronic Care; Chronic Disease; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Data; Devices; Diagnostic tests; Disadvantaged; Discipline; Disparity; Dissemination and Implementation; Diverse Workforce; Economics; Effectiveness; Elderly; Elements; Ensure; Environmental Risk Factor; Equity; Ethics; Faculty; Federally Qualified Health Center; Foundations; Funding; Generations; Goals; Grant; Growth; HIV; Health; Healthy Eating; Heart failure; Hispanic Populations; Hypertension; Industry; Infant Mortality; Information Dissemination; Institution; Intervention; Investments; Laboratories; Leadership; Lesbian Gay Bisexual Transgender Queer; Life Expectancy; Link; Medical; Medical center; Medicine; Methods; Minority Groups; Mission; Non-Insulin-Dependent Diabetes Mellitus; Ohio; Outcome; Participant; Patients; Persons; Pharmaceutical Preparations; Play; Population; Positioning Attribute; Privatization; Procedures; Process; Public Health; Public Health Informatics; Rehabilitation device; Research; Research Personnel; Resource-limited setting; Resources; Role; Rural; Safety; Services; Site; Solid; Special Population; Structural Racism; System; Technology; Testing; Training; Training Programs; Training and Education; Translation Process; Translational Research; Underrepresented Minority; Underrepresented Populations; United States Department of Veterans Affairs; Universities; University Hospitals; Vulnerable Populations; Work; Workforce Development; clinical practice; collaborative environment; community engagement; community setting; design; disparity elimination; disparity gap; experience; health disparity; health equity; health equity promotion; high risk population; implementation strategy; improved; innovation; medical schools; next generation; novel; novel strategies; novel therapeutics; opioid mortality; point-of-care diagnostics; poor health outcome; primary care practice; programs; recruit; research clinical testing; rural area; rural dwellers; social; sociocultural determinant; structural determinants; success; translational research program; translational scientist

PROJECT SUMMARY/ABSTRACT For the past 15 years, the Clinical and Translational Science Collaborative (CTSC) at Case Western Reserve University (CWRU) has linked clinical and translational research efforts at five independent institutions— CWRU, Cleveland Clinic, MetroHealth System, University Hospitals of Cleveland, and Louis Stokes Cleveland Veterans Affairs Medical Center. Two new partners (University of Toledo School of Medicine and Northeast Ohio Medical University) are now being added to extend the CTSC’s reach across Northern Ohio. The CWRU CTSC has a strong track record of enhancing the quantity and quality of Clinical and Translational Science (CTS) among our partners by facilitating novel research paradigms, technologies, and training. Our CTSC has developed a new generation of researchers, enhanced collaborations among investigators, streamlined discovery by building partnerships among industry and community and organizational partners, and facilitated many successful entrepreneurial startups. Building on this solid foundation, the CWRU CTSC proposes an expanded focus on health equity, reflected in the project theme Catalyzing Linkages to Equity in Health (CLE Health). Social, economic, and environmental disadvantages are linked to poor health outcomes and lead to disparities in life expectancy, infant mortality, and rates of chronic conditions. Minority groups are often underrepresented in clinical trials as well, meaning there can be insufficient data for understanding the effectiveness or safety of new drugs, procedures, or health interventions for different populations. The overall goals of this project are to 1) understand the fundamental barriers to optimal recruitment of underrepresented groups in clinical trials and test and scale interventions aimed at breaking down these barriers to diversify study engagement, 2) facilitate and expedite innovation in multicenter clinical and translational research by fully integrating community and stakeholder partners and ensuring that this research represents the experiences of all and results in health improvements for all, 3) disseminate and implement novel and responsive research programs across clinical and community settings to advance access to health interventions that aim to promote health equity, and 4) create and disseminate inclusive and high impact educational and training programs for translational research professionals of all disciplines and levels, both in clinical and community settings. The CTSC has designed a Strategic Management Core and six CTS research and training Elements to accomplish these goals: Workforce Development, Community & Stakeholder Engagement, Resources & Services, CTS Pilot, Health Informatics, and CTS Research Program. We are committed to innovative and collaborative practice and dissemination of results so that everyone in Northern Ohio—and beyond—can benefit from advances in CTS in our programs and discoveries.

项目摘要/摘要 在过去的15年里，凯斯西储的临床和转化科学合作组织（CTSC） 大学（CWRU）在五个独立机构的临床和转化研究工作相联系- CWRU、克利夫兰诊所、MetroHealth System、克利夫兰大学医院和Louis Stokes Cleveland 退伍军人事务医疗中心两个新的合作伙伴（托莱多大学医学院和东北大学） 俄亥俄州医科大学）现在正在增加，以扩大CTSC的覆盖面整个北方俄亥俄州。CWRU CTSC在提高临床和转化科学的数量和质量方面有着良好的记录 (CTS)通过促进新的研究范式，技术和培训，我们的合作伙伴之间。我们的CTSC已 培养了新一代的研究人员，加强了研究人员之间的合作， 通过在行业、社区和组织合作伙伴之间建立伙伴关系， 许多成功的创业公司。在这一坚实的基础上，CWRU CTSC提出了一个 扩大对卫生公平的关注，反映在项目主题“促进与卫生公平的联系”中 健康）。社会、经济和环境不利因素与健康状况不佳有关， 预期寿命、婴儿死亡率和慢性病发病率方面的差距。少数民族往往 在临床试验中也代表性不足，这意味着可能没有足够的数据来了解 新药物、程序或健康干预措施对不同人群的有效性或安全性。整体 该项目的目标是：1）了解最佳征聘代表性不足的人的基本障碍 在临床试验和测试和规模干预，旨在打破这些障碍，以多样化的群体， 研究参与，2）通过以下方式促进和加快多中心临床和转化研究的创新 充分整合社区和利益相关者合作伙伴，并确保这项研究代表 3）传播和实施新的和 跨临床和社区环境的响应性研究计划，以促进获得健康 旨在促进卫生公平的干预措施，以及4）创造和传播包容性和高影响力 为所有学科和水平的翻译研究专业人员提供教育和培训计划， 临床和社区环境。CTSC设计了一个战略管理核心和六个CTS研究 实现这些目标的要素：劳动力发展、社区和利益相关者 参与，资源和服务，CTS试点，健康信息学和CTS研究计划。我们 致力于创新和协作的实践和成果的传播，使每个人在北方 俄亥俄州及其他地区可以从我们的计划和发现中的CTS进步中受益。

项目成果

Does rickets carry an increased risk of osteomyelitis and septic arthritis? An aggregated electronic health record data study.

佝偻病是否会增加患骨髓炎和化脓性关节炎的风险？

• DOI: 10.1097/bpb.0000000000001168
• 发表时间: 2024
• 期刊: Journal of pediatric orthopedics. Part B
• 作者: Lavu,MonishS;VanDorn,Chloe;Bobak,Lukas;Burkhart,RobertJ;Kaelber,DavidC;Mistovich,RJustin
• 通讯作者: Mistovich,RJustin

Prevalence of neuromyelitis optica spectrum disorder in the United States.

美国视神经脊髓炎谱系疾病的患病率。

• DOI: 10.1177/13524585231224683
• 发表时间: 2024
• 期刊: Multiple sclerosis (Houndmills, Basingstoke, England)
• 作者: Briggs,FarrenBs;Shaia,Jacqueline
• 通讯作者: Shaia,Jacqueline

Pre-appendectomy hyponatremia is associated with increased rates of complicated appendicitis.

• DOI: 10.1016/j.sopen.2023.05.001
• 发表时间: 2023-06
• 期刊: SURGERY OPEN SCIENCE
• 影响因子: 1.4
• 作者: Poston, Lauren M.;Leavitt, Tripp;Pope, Samantha;Hill, Hannah;Tollinche, Luis E.;Kaelber, David C.;Alter, Jonathan A.
• 通讯作者: Alter, Jonathan A.

New-onset autoimmune disease after COVID-19.

COVID-19 后新发的自身免疫性疾病。

• DOI: 10.3389/fimmu.2024.1337406
• 发表时间: 2024
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Hileman,CorrilynnO;Malakooti,ShahdiK;Patil,Nirav;Singer,NoraG;McComsey,GraceA
• 通讯作者: McComsey,GraceA

A Cluster Randomized Trial of Primary Care Practice Redesign to Integrate Behavioral Health for Those Who Need It Most: Patients With Multiple Chronic Conditions.

重新设计初级保健实践的集群随机试验，为最需要的人（患有多种慢性病的患者）整合行为健康。

• DOI: 10.1370/afm.3027
• 发表时间: 2023
• 期刊: Annals of family medicine
• 影响因子: 4.4
• 作者: Littenberg,Benjamin;Clifton,Jessica;Crocker,AbigailM;Baldwin,Laura-Mae;Bonnell,LeviN;Breshears,RyanE;Callas,Peter;Chakravarti,Prama;Clark/Keefe,Kelly;Cohen,DeborahJ;deGruy,FrankV;Eidt-Pearson,Lauren;Elder,William;Fox,Cheste
• 通讯作者: Fox,Cheste