K24 Mid-Career Investigator Award in Eating and Weight Disorders

描述(由申请者提供)：这份申请代表着K24职业生涯中期研究人员奖在饮食和体重障碍方面以患者为导向的竞争性续展。格里洛博士正在寻求延长K24奖，以便将他从行政和临床职责中解放出来，以确保有保护的时间继续：(1)专注于临床研究，以改进饮食/体重障碍的治疗方法；(2)开发所需的高级研究技能，以进一步提高他作为研究人员和导师的效力，以便积极影响下一代治疗方法和研究人员；以及(3)指导肥胖和饮食失调领域的博士后临床研究人员和初级教员，以解决这些日益严重的公共卫生问题。在最初的资助期间，Grilo博士完成了三项随机对照试验，从NIH获得了两项R01的PI和一项基金会赠款，以在不同的环境中为患有饮食障碍的肥胖患者进行RCT，并作为NIH的几项赠款的联合调查员。在最初的K24期间，Grilo博士发表了110篇同行评议的研究论文，指导了20名实习生或初级教师，指导了6个成功的NIH贷款偿还计划申请，并指导或共同指导了5个资助的K23职业发展奖。续签奖项将使格里洛博士能够进一步增加他的综合研究和指导活动。在正在进行的研究中，可以进行密集指导，包括对患有暴饮暴食障碍的肥胖症患者进行随机对照试验(RCT)测试，采用分级护理方法对患有暴饮暴食障碍的肥胖患者进行标准行为减肥治疗(R01 DK49587)，以及对患有暴饮暴食障碍的肥胖患者进行随机对照试验(R01 DK073542)，通过自助和药物疗法单独和联合进行认知行为疗法(R01 DK073542)。续签奖项将允许格里洛博士对患有暴饮暴食障碍的肥胖症患者在认知控制任务和奖励处理过程中的神经激活进行试点fMRI研究。续签奖项还将使格里洛博士进一步提高他的科学能力，他已经获得了国际公认的肥胖症、饮食失调、治疗方法、生物统计学和神经生物学研究方面的专家顾问的合作。格里洛博士的项目与耶鲁大学的其他临床研究和培训项目(如CTSA)相结合，共同提供了充足的机会和资源。Grilo博士将继续支持和促进饮食/体重紊乱领域的博士后和初级教师临床研究人员的进步，通过密集的指导，以完成研究项目，发表研究报告，并成功获得职业发展(如K23)和研究资助。

DESCRIPTION (provided by applicant): This application represents a competitive renewal of a K24 Mid-Career Investigator Award in Patient-Oriented Research in Eating and Weight Disorders. Dr. Grilo is seeking a renewal of the K24 Award in order to relieve him from administrative and clinical duties to ensure protected time to continue to: (1) focus on clinical- research to improve treatment methods for eating/weight disorders; (2) develop advanced research skills needed to enhance further his effectiveness both as a researcher and as a mentor in order to positively impact the next generation of treatment methods and researchers; and (3) mentor postdoctoral clinical researchers and junior faculty in the area of obesity and disordered eating needed to address these growing major public health problems. During the initial funded period, Dr. Grilo completed three RCTs, obtained new funding as PI on two R01s from the NIH and a Foundation Grant to perform RCTs for obese patients with disordered eating in diverse settings, and as co-Investigator on several NIH grants. During the initial K24, Dr. Grilo published 110 peer-reviewed research papers, mentored 20 trainees or junior faculty, mentored six successful NIH Loan Repayment Program applications, and mentored or co-mentored five funded K23 Career Development Awards. A renewal award will allow Dr. Grilo to increase further his integrated research and mentoring activities. Among the on-going studies that will allow for intensive mentoring include a RCT testing a stepped care approach to a standard behavioral weight loss treatment for obese patients with binge eating disorder (R01 DK49587) and a RCT testing cognitive behavioral therapy via self-help and pharmacotherapy, alone and in combination, in obese patients with binge eating disorder in generalist primary care settings (R01 DK073542). A renewal award will allow Dr. Grilo to perform pilot fMRI investigations of neural activation during cognitive control tasks and reward processing in obese patients with binge eating disorder. A renewal award will also allow Dr. Grilo to advance further his scientific capabilities and he has secured the collaboration of internationally-recognized expert consultants in obesity, eating disorders, treatment methods, biostatistics, and neurobiological research. Dr. Grilo's program is integrated with other clinical-research and training programs (e.g., CTSA) at Yale which collectively offer ample opportunities and resources. Dr. Grilo will continue to support and facilitate the advancement of postdoctoral and junior faculty clinical-researchers in eating/weight disorders via intensive mentoring geared towards completing research projects, publishing studies, and successfully obtaining career development (e.g., K23) and research grant support.