Cannabinoid Function in the CNS: From Molecules to Disease Mechanisms

 描述(由申请人提供)：本申请作为R13拨款提交，请求支持将于2015年和2017年举行的联合戈登研究会议和戈登研究研讨会(GRC/GRS)，主题为“大麻素在中枢神经系统的作用”。我们将受益于创新的GRC/GRS格式：1.促进科学论坛，以便深入介绍和充分讨论神经系统(内源性)大麻类化合物功能领域尚未发表的开创性成果；2.为杰出的协作科学创造机会，推动下一代科学进步。我们将通过联合基础研究人员和他们的临床同行来强调大麻类药物研究的关键翻译意义，这些研究人员正在研究调节内源性大麻素功能在疾病状态中的长期影响；3.通过戈登研究研讨会吸引、支持和指导下一代(内源性)大麻类药物研究人员，该研讨会将特别关注科学和出版过程中的女性。联席会议的形式是必要的，因为内源性大麻素在许多器官系统的发育、生理学和病理生理学方面已经确立了作用，最突出的是中枢神经系统，以及它与最具破坏性的神经精神疾病的因果关系或联系关系。关于人体使用医用(如Sativex)和娱乐用大麻的立法目前的势头突出表明，即将举行的GRC/GRS会议对于确定未来在发育(如孕期和青少年)和成人背景下的研究需求至关重要，特别是在成瘾、精神分裂症、抑郁症、自闭症和神经变性的病理机制方面。因此，这些GRC/GRS会议可以作为研究大麻类药物的长期后果(即滥用倾向、不良副作用、安全性考虑)的垫脚石，并吸引关键的临床研究人员，他们不会参加仅在基础研究背景下致力于疾病机制的戈登研究会议。因此，GRC的形式是促进跨学科科学的一个重要机会，旨在与人类神经精神疾病作斗争。戈登研究研讨会(“从分子到网络”)将通过提供指导和网络机会，专门解决研究生和博士后研究员的需求。我们认识到与会者处于职业发展的关键阶段，因此将在2015年组织“科学中的女性”和“社论问答”会议，以立即讨论两个最紧迫的职业主题。GRS将直接先于GRC，因此许多年轻的调查人员可以联合GRC/GRS留下来。总体而言，我们预计这些杰出的会议将确定未来几十年的关键研究领域。

 DESCRIPTION (provided by applicant): The present application submitted as an R13 grant requests support for joint Gordon Research Conferences and Gordon Research Seminars (GRC/GRS) on "Cannabinoid Function in the CNS" to be held in 2015 and 2017. We will benefit from the innovative GRC/GRS format to: 1. Promote a scientific forum to allow the in-depth presentation and adequate discussion of groundbreaking unpublished results in the area of (endo-) cannabinoid functions in the nervous system, 2. Foster opportunities for outstanding collaborative science to propel the next generation of scientific advances. We will emphasize the key translational meaning of cannabinoid research by uniting fundamental researchers and their clinical peers studying the long-term impact of modulating endocannabinoid functions in disease states, 3. Attract, support and mentor the next generation of (endo-) cannabinoid researchers through the Gordon Research Seminar, which will have an additional focus on women in science and the publishing process. The joint meeting format is warranted because of the established role of endocannabinoids in the development, physiology and pathophysiology of many organ systems, most prominently the central nervous system, and its causal or associative relationship to the most devastating neuropsychiatric illnesses. The present momentum of the rapidly shifting legislation regarding the use of medical (e.g. Sativex) and recreational cannabis in humans highlights the forthcoming GRC/GRS meetings as critical to defining future research needs in both developmental (e.g. during pregnancy and adolescent) and adult contexts, particularly in relation to pathomechanisms of addiction, schizophrenia, depression, autism and neurodegeneration. Therefore, these GRC/GRS meetings can act as stepping-stones towards the study of long-term consequences (i.e. abuse liability, adverse side-effects, safety considerations) of cannabinoid medication, and attract key clinical researchers, who would not attend a Gordon Research Conference solely dedicated to disease mechanisms in a fundamental research setting. The format of the GRC thus represents a critical opportunity to foster interdisciplinary science aimed to combat human neuropsychiatric illnesses. The Gordon Research Seminar ("From molecules to networks") will specifically address the needs of graduate students and post-doctoral fellows by providing mentoring and networking opportunities. We recognize the critical stage of career development for the attendees and therefore will organize, in 2015, "women in science" and "editorial Q&A" sessions to immediately address two of the most pressing career topics. The GRS will directly precede the GRC, thus allowing joint GRC/GRS stay for many young investigators. Overall, we expect these outstanding meetings to define key areas of research for decades to come.