Comprehensive quantitative ultrafast 3D liver MRI

综合定量超快 3D 肝脏 MRI

• 批准号: 8905601
• 负责人: Vikas Gulani
• 金额: $ 52.94万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8905601
• 关键词: Abdomen; Acceleration; Address; Adopted; Benign; Biopsy; Brain; Breathing; Clinical; Data Set; Dependence; Development; Diagnosis; Diagnostic; Diffusion; Discrimination; Disease; Fatty acid glycerol esters; Gold; Health; Image; Injection of therapeutic agent; Lead; Lesion; Liver; Liver diseases; Magnetic Resonance Imaging; Maps; Measurement; Methods; Modeling; Monitor; Morphologic artifacts; Nature; Organ; Pathology; Patients; Perfusion; Phase; Property; Protocols documentation; Reader; Reading; Relaxation; Resolution; Sampling; Scanning; Scheme; Series; Techniques; Testing; Time; Tissues; Validation; Water; Weight; Work; contrast enhanced; data acquisition; diagnostic accuracy; diffusion weighted; disease diagnosis; experience; follow-up; imaging modality; improved; liver biopsy; liver imaging; novel; prevent; quantitative imaging; radiologist; reconstruction; research study; saturated fat; signal processing; soft tissue; tool

DESCRIPTION (provided by applicant): Approximately 7% of the 30.2 million MR exams performed in 2006 were abdominal MRIs, and the liver is by far the most common abdominal organ imaged using MR [1]. When successful, lesion characterization by MR is exquisite and elegant, and the definitive nature of the information can aid treatment follow-up, stop unnecessary workups and prevent invasive biopsies. All too often, however, liver MR is unsuccessful because of patient difficulties with breath-holds, problems with timing or acquisition in the critical (and non-repeatable) timed post-contrast series of images, operator dependence, image artifacts, or differences in levels of certainty in interpretation between various radiologists arising from inherently qualitative interpretations. Weighted images are at best surrogates of the underlying parameter and often poorly reflect the parameters [2]. Moreover, when quantitative information is available, it can outperform even expert readers of clinical contrasts [3]. If the liver examination could be performed quickly during free-breathing, without relying on operator expertise, and could provide quantitative parameters which can be used to definitively diagnose disease, the impact on the diagnosis and treatment of liver diseases would be significant. We propose to leverage rapid imaging, parameter quantitation, and body MRI expertise in our group to provide a rapid, quantitative, high quality 3D exam in under 10 minutes. A standard liver MR exam consists of multiple scans highlighting different contrast mechanisms: T2 weighted scans without and with fat saturation, T1-weighted in- and opposed-phase gradient echo, diffusion images, and T1-weighted fat saturated 3D gradient echo scans pre- and at least 3 timed phases post-contrast). We will develop, optimize and validate methods to generate quantitative measurements of each mechanism, by developing quantitative 3D high resolution DCE perfusion, fat fraction, T1 and T2 mapping, and improved 3D diffusion mapping. The diagnostic value of the new protocol will then be extensively tested on patients with biopsy proven pathologies, and will be compared to the present clinical standard.

描述(申请人提供)：在2006年进行的3020万例磁共振检查中，大约7%是腹部磁共振成像，肝脏是迄今为止使用磁共振成像最常见的腹部器官[1]。如果成功，MR对病变的描述是精致和优雅的，信息的决定性性质可以帮助治疗后续，停止不必要的工作和防止侵入性活组织检查。然而，由于患者屏气困难、关键的(且不可重复的)定时增强后图像序列中的定时或获取问题、操作员依赖性、图像伪影或不同放射科医生之间因内在定性解释而引起的解释确定性水平的差异，肝脏MR常常不成功。加权图像充其量是潜在参数的替代，通常不能很好地反映参数[2]。此外，当定量信息可用时，它甚至可以胜过临床对比的专家读者[3]。如果能在自由呼吸时快速进行肝脏检查，而不依赖于操作员的专业知识，并能提供可用于明确诊断疾病的定量参数，将对肝脏疾病的诊断和治疗产生重大影响。我们建议利用我们团队的快速成像、参数量化和身体MRI专业知识，在10分钟内提供快速、定量、高质量的3D检查。标准的肝脏MR检查由多个扫描组成，突出不同的对比机制：T2加权扫描，无脂肪饱和和有脂肪饱和扫描，T1加权内和反相位梯度回波，弥散成像，以及T1加权饱和脂肪3D梯度回波扫描(增强前后至少3个时间段)。我们将通过开发定量的3D高分辨率DCE灌注、脂肪分数、T1和T2图以及改进的3D扩散图来开发、优化和验证生成每个机制的定量测量的方法。新方案的诊断价值随后将在有活检证实的病理的患者身上进行广泛测试，并将与目前的临床标准进行比较。