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Plasticity of Audiovisual Movement Representations: Implications for Limb Apraxia

视听运动表征的可塑性：对肢体失用症的影响

基本信息

批准号：
8675880
负责人：
Brenda Hanna-Pladdy
金额：
$ 12.91万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-22 至 2016-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8675880
关键词：
Abbreviations Affect Aging Auditory Behavioral Behavioral Paradigm Bilateral Biological Neural Networks Brain Brain imaging Caregivers Clinical Cognitive Collaborations Consensus Contralateral Cues Data Dependence Development Disease Environment Event Financial compensation Fostering Foundations Functional Magnetic Resonance Imaging Gestures Hand Ideomotor Apraxia Impaired cognition Inferior Kansas Left Lesion Limb structure Linguistics Lobule Maps Measures Mediating Medical center Mentors Mentorship Modality Motion Motor Movement Movement Disorders Nature Neurologic Neuronal Plasticity Parietal Patients Pattern Performance Posture Process Psychiatry Public Health Quality of life Reaction Time Recovery Rehabilitation therapy Research Research Design Retrieval Role Scanning Scientist Semantics Sensory Severities Stroke Superior temporal gyrus Survivors Symptoms System Techniques Time Universities Visual Work base career cost disability hemiparesis improved insight limb movement mirror neuron motor deficit multisensory neuromechanism nonhuman primate post stroke professor programs relating to nervous system skills social sound spatiotemporal stroke recovery theories tool

项目摘要

DESCRIPTION (provided by applicant): Dr. Brenda Hanna-Pladdy is a clinical neuropsychologist and Assistant Professor in the Landon Center on Aging and Department of Psychiatry at the University of Kansas Medical Center (KUMC). The purpose of this proposal is to foster the scientific development in stroke recovery mechanisms and fMRI skills of the candidate, so that she may become an independent clinical scientist. The Landon Center on Aging and the Hoglund Brain Imaging Center at KUMC will provide the candidate with the ideal setting to investigate the neural mechanisms subserving skilled movements and the recovery of apraxia following stroke. The long-term objective of this research plan is to explore the multisensory nature of movement representations in the praxis system in order to identify rehabilitation targets. Ideomotor apraxia (IMA) is a skilled movement disorder that is common after left hemisphere (LH) stroke, and may contribute to significant disability in the everyday environment. The collaboration with the primary mentor (Dr. Nudo) will allow the candidate to obtain the foundation for the development of an independent academic career by expanding the candidate's scientific background in stroke recovery and neuroplasticity, and promoting her research and grantsmanship skills. The co-mentors will provide mentorship in fMRI techniques and lesion-symptom mapping in stroke (Dr. Savage), and neuroanatomical and clinical aspects of skilled movement disorders (Dr. Haaland). The proposed study will utilize an event-related fMRI study designed to distinguish regions involved in retrieving the spatiotemporal features of familiar tools/objects (without actual movement) when elicited by auditory, visual and multisensory cues. These activation patterns will be correlated to a behavioral paradigm measuring the quality of movement trajectories in LH stroke patients (with and without apraxia) and normal controls to determine if the addition of auditory motion cues to visual cues (i.e., multisensory cues) may provide better access to movement representations. The aims are the following (i) to characterize how sensory cues facilitate the retrieval of object action features, (ii) to elucidate the neural substrates of praxis and the multisensory nature of movement representations, and (iii) to evaluate functional adaptation in audiovisual movement representations following LH stroke. This data will elucidate the functional and anatomical basis for apraxia, and help identify appropriate sensory cues for rehabilitation of limb apraxia following stroke.

描述（由申请人提供）：Brenda Hanna-Pladdy 博士是堪萨斯大学医学中心 (KUMC) 兰登老龄化中心和精神病学系的临床神经心理学家和助理教授。该提案的目的是促进候选人在中风恢复机制和功能磁共振成像技能方面的科学发展，使她成为一名独立的临床科学家。 KUMC 的兰登衰老中心和霍格伦德脑成像中心将为候选人提供理想的环境，以研究促进熟练运动和中风后失用症恢复的神经机制。该研究计划的长期目标是探索实践系统中运动表征的多感官性质，以便确定康复目标。意念运动性失用症 (IMA) 是一种熟练运动障碍，在左半球 (LH) 中风后很常见，可能会导致日常环境中的严重残疾。与主要导师（Nudo 博士）的合作将使候选人通过扩大候选人在中风恢复和神经可塑性方面的科学背景，并提升她的研究和资助技能，为独立学术生涯的发展奠定基础。共同导师将在功能磁共振成像技术和中风病变症状图谱（Savage 博士）以及熟练运动障碍的神经解剖学和临床方面（Haaland 博士）提供指导。拟议的研究将利用与事件相关的功能磁共振成像研究，旨在区分在听觉、视觉和多感官线索引发时检索熟悉工具/物体（没有实际运动）的时空特征所涉及的区域。这些激活模式将与测量 LH 中风患者（有或没有失用症）和正常对照的运动轨迹质量的行为范式相关联，以确定在视觉线索（即多感官线索）中添加听觉运动线索是否可以提供更好的运动表征。目的如下：（i）描述感觉线索如何促进物体动作特征的检索，（ii）阐明实践的神经基础和运动表征的多感官本质，以及（iii）评估左旋中风后视听运动表征的功能适应。这些数据将阐明失用症的功能和解剖学基础，并帮助确定中风后肢体失用症康复的适当感觉线索。