Plasticity of Audiovisual Movement Representations: Implications for Limb Apraxia

描述(申请人提供)：布伦达·汉纳-普拉迪博士是堪萨斯大学医学中心(KUMC)兰登老龄中心和精神病学系的临床神经心理学家和助理教授。这项建议的目的是促进候选人在中风康复机制和fMRI技能方面的科学发展，使她可能成为一名独立的临床科学家。昆士兰大学兰登衰老中心和霍格伦德脑成像中心将为考生提供理想的环境，以研究中风后熟练运动和失用恢复的神经机制。这项研究计划的长期目标是探索练习系统中运动表征的多感官性质，以确定康复目标。理想性运动性失用症(IMA)是左半球卒中后常见的一种技术性运动障碍，可能导致日常生活中的严重残疾。与主要导师(Nudo博士)的合作将使候选人能够通过扩大候选人在中风康复和神经可塑性方面的科学背景，并促进她的研究和砂砾技能，为独立学术生涯的发展奠定基础。合作导师将指导中风的功能磁共振成像技术和病变-症状图谱(萨维奇博士)，以及熟练运动障碍的神经解剖学和临床方面(哈兰德博士)。这项拟议的研究将利用一项与事件相关的功能磁共振研究，旨在区分在听觉、视觉和多感官提示引发时，提取熟悉工具/物体(没有实际运动)的时空特征所涉及的区域。这些激活模式将与测量LH型中风患者(有或没有失用症)和正常对照组运动轨迹质量的行为范式相关联，以确定是否将听觉运动线索添加到视觉线索(即多感觉线索)可能提供更好的运动表征途径。本研究的目的如下：(1)表征感觉线索如何促进物体动作特征的提取；(2)阐明动作表征的神经基础和运动表征的多感官本质；(3)评价左侧卒中后视听运动表征的功能适应。这些数据将阐明失用的功能和解剖学基础，并有助于为中风后肢体失用的康复寻找合适的感官线索。

DESCRIPTION (provided by applicant): Dr. Brenda Hanna-Pladdy is a clinical neuropsychologist and Assistant Professor in the Landon Center on Aging and Department of Psychiatry at the University of Kansas Medical Center (KUMC). The purpose of this proposal is to foster the scientific development in stroke recovery mechanisms and fMRI skills of the candidate, so that she may become an independent clinical scientist. The Landon Center on Aging and the Hoglund Brain Imaging Center at KUMC will provide the candidate with the ideal setting to investigate the neural mechanisms subserving skilled movements and the recovery of apraxia following stroke. The long-term objective of this research plan is to explore the multisensory nature of movement representations in the praxis system in order to identify rehabilitation targets. Ideomotor apraxia (IMA) is a skilled movement disorder that is common after left hemisphere (LH) stroke, and may contribute to significant disability in the everyday environment. The collaboration with the primary mentor (Dr. Nudo) will allow the candidate to obtain the foundation for the development of an independent academic career by expanding the candidate's scientific background in stroke recovery and neuroplasticity, and promoting her research and grantsmanship skills. The co-mentors will provide mentorship in fMRI techniques and lesion-symptom mapping in stroke (Dr. Savage), and neuroanatomical and clinical aspects of skilled movement disorders (Dr. Haaland). The proposed study will utilize an event-related fMRI study designed to distinguish regions involved in retrieving the spatiotemporal features of familiar tools/objects (without actual movement) when elicited by auditory, visual and multisensory cues. These activation patterns will be correlated to a behavioral paradigm measuring the quality of movement trajectories in LH stroke patients (with and without apraxia) and normal controls to determine if the addition of auditory motion cues to visual cues (i.e., multisensory cues) may provide better access to movement representations. The aims are the following (i) to characterize how sensory cues facilitate the retrieval of object action features, (ii) to elucidate the neural substrates of praxis and the multisensory nature of movement representations, and (iii) to evaluate functional adaptation in audiovisual movement representations following LH stroke. This data will elucidate the functional and anatomical basis for apraxia, and help identify appropriate sensory cues for rehabilitation of limb apraxia following stroke.