Analytical - Core B
分析 - 核心 B
基本信息
- 批准号:8935552
- 负责人:
- 金额:$ 31.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-05 至 2020-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAnatomyAntibodiesAreaBiochemicalBiological AssayBrain regionCardiovascular systemChronicCore FacilityCoupledData AnalysesData FilesDatabasesDrug CompoundingEquipmentFunctional disorderGene ProteinsGenomicsHarvestHealth SciencesHuman ResourcesHypoxiaImmunohistochemistryInstructionLabelMass Spectrum AnalysisMethodsMissionNeuronsPeptidesPhysiologyPopulationPost-Translational Protein ProcessingPreparationProceduresProcessProteinsProteomicsRNAReagentReporterResearchResearch InstituteResearch PersonnelResourcesSamplingScheduleSecureSiteSleep Apnea SyndromesSpecialistSystemTechnical ExpertiseTissue SampleWestern BlottingWorkabstractingbrain cellcostinsightinstructorinterestkit proteinlaser capture microdissectionprofessorresearch studysample collection
项目摘要
Abstract – Core B
This core focuses on qualitative and quantitative analyses of genes, proteins, peptides and small drug
compounds using conventional biochemical methods coupled with highly sensitive mass spectrometry (MS)
and Laser Capture Microdissection (LCM) for sample collection. It will serve as a central resource for LCM and
qRT-PCR (UNTHSC) and MS analysis of covalent protein modifications (UTHSCSA) of CNS samples from the
3 projects. The core will receive raw samples from investigators, most often these will be in the form of
punches from specific brain regions of interest. LCM will be used to harvest defined populations of cells from
brain sections allowing the projects to conduct experiments using samples that are more specific than punched
samples. Retrograde track tracing, juxtacellular labeling, immunohistochemistry, and the expression of reporter
molecules will be used to identify neurons of interest.
摘要-核心B
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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J Thomas Cunningham其他文献
J Thomas Cunningham的其他文献
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{{ truncateString('J Thomas Cunningham', 18)}}的其他基金
Intermittent hypoxia and hypertension: Role of the lamina terminalis
间歇性缺氧和高血压:终板的作用
- 批准号:
10548872 - 财政年份:2021
- 资助金额:
$ 31.7万 - 项目类别:
Intermittent hypoxia and hypertension: Role of the lamina terminalis
间歇性缺氧和高血压:终板的作用
- 批准号:
10330441 - 财政年份:2021
- 资助金额:
$ 31.7万 - 项目类别:
Neural Regulation of Vasopressin Release in a Model of Dilutional Hyponatremia
稀释性低钠血症模型中加压素释放的神经调节
- 批准号:
9895545 - 财政年份:2018
- 资助金额:
$ 31.7万 - 项目类别:
Homeostatic Regulation of Supraoptic Neurons: Role of BDNF
视上神经元的稳态调节:BDNF 的作用
- 批准号:
8835145 - 财政年份:2014
- 资助金额:
$ 31.7万 - 项目类别:
Homeostatic Regulation of Supraoptic Neurons: Role of BDNF
视上神经元的稳态调节:BDNF 的作用
- 批准号:
8695603 - 财政年份:2014
- 资助金额:
$ 31.7万 - 项目类别:
Homeostatic Regulation of Supraoptic Neurons: Role of BDNF
视上神经元的稳态调节:BDNF 的作用
- 批准号:
9242065 - 财政年份:2014
- 资助金额:
$ 31.7万 - 项目类别:
Intermittent Hypoxia-Induced Hypertension: Roles of Angiotensin and Chloride Transport in the Lamina Terminalis.
间歇性缺氧引起的高血压:血管紧张素和氯离子转运在终层中的作用。
- 批准号:
9253104 - 财政年份:2008
- 资助金额:
$ 31.7万 - 项目类别:
Intermittent Hypoxia-Induced Hypertension: Roles of Angiotensin and Chloride Transport in the Lamina Terminalis.
间歇性缺氧引起的高血压:血管紧张素和氯离子转运在终层中的作用。
- 批准号:
9096158 - 财政年份:2008
- 资助金额:
$ 31.7万 - 项目类别:
CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
后肢未体重大鼠钠摄入量的控制
- 批准号:
6844307 - 财政年份:2001
- 资助金额:
$ 31.7万 - 项目类别:
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