CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT

后肢未体重大鼠钠摄入量的控制

• 批准号: 6844307
• 负责人: J Thomas Cunningham
• 金额: $ 18.62万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6844307
• 关键词: baroreceptors; controlled environment chamber; denervation; disease /disorder model; electrolyte balance; gravity; hormone regulation /control mechanism; immobilization of body part; laboratory rat; leg; neuroregulation; nutrition related tag; restricted physical activity; salt intake; saluresis

DESCRIPTION (Verbatim from the application): In the hind limb unweighted (HU) rat model of bed rest and microgravity, HU results in a central movement of body fluid, diuresis and natriuresis, resulting in a decrease in plasma volume. We have observed that rats increase ingestion of saline solution during 24h HU. Further, this ingestion of saline inhibits the decrease in plasma volume normally observed in 24h HU rats. The studies proposed examine the integration of neural and humoral factors influencing sodium ingestion in the HU model of bed rest. The specific aims of the study are: Specific aim 1: Investigate the role of the renal nerves in promoting sodium intake during 24 h HU. Specific aim 2: Investigate the role of hormones in promoting sodium intake during HU. Specific aim 3: Examine the role of the cardiac afferent nerves in regulating the intake of sodium. Specific aim 4: Compare short term (24 h) and long term (14 d) effects of HU on sodium ingestion and plasma volume. We hypothesize that increases in renal afferent nerve activity is critical to HU-induced sodium ingestion. Furthermore, elevated aldosterone may contribute to the ingestion of sodium while stimulation of cardiac afferent nerves may inhibit sodium intake in this model. Integration of these signals by the central nervous system results in a modest sodium intake and maintains plasma volume during HU. During prolonged HU, adaptations may occur which further influence both the ingestion of sodium and blood volume. Understanding bed rest and microgravity-induced changes in body fluid balance requires understanding such factors as the acquisition of solutes. It is hoped that these experiments will contribute to an understanding of both the regulation of body fluid during prolonged bed rest and the problems associated with return to normal posture. Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure.

描述（来自申请书）：后肢无重量（HU）

项目成果

Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.

通过 c-Fos 和诱导型 cAMP 早期阻遏物免疫细胞化学，在清醒大鼠中中央显微注射痛敏肽/孤啡宁 FQ 来鉴定参与水利尿反应的中枢神经系统部位。

• DOI: 10.1111/j.1365-2826.2007.01559.x
• 发表时间: 2007
• 期刊: Journal of neuroendocrinology
• 影响因子: 3.2
• 作者: Gottlieb,HB;Fleming,TM;Ji,L;Cunningham,JT
• 通讯作者: Cunningham,JT

Selective up-regulation of JunD transcript and protein expression in vasopressinergic supraoptic nucleus neurones in water-deprived rats.

缺水大鼠血管加压素视上核神经元 JunD 转录物和蛋白表达的选择性上调。

• DOI: 10.1111/j.1365-2826.2012.02362.x
• 发表时间: 2012
• 期刊: Journal of neuroendocrinology
• 影响因子: 3.2
• 作者: Yao,ST;Gouraud,SS;Qiu,J;Cunningham,JT;Paton,JFR;Murphy,D
• 通讯作者: Murphy,D