权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT

后肢未体重大鼠钠摄入量的控制

基本信息

批准号：
6844307
负责人：
J Thomas Cunningham
金额：
$ 18.62万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-02-01 至 2007-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6844307
关键词：
baroreceptors controlled environment chamber denervation disease /disorder model electrolyte balance gravity hormone regulation /control mechanism immobilization of body part laboratory rat leg neuroregulation nutrition related tag restricted physical activity salt intake saluresis

项目摘要

DESCRIPTION (Verbatim from the application): In the hind limb unweighted (HU) rat model of bed rest and microgravity, HU results in a central movement of body fluid, diuresis and natriuresis, resulting in a decrease in plasma volume. We have observed that rats increase ingestion of saline solution during 24h HU. Further, this ingestion of saline inhibits the decrease in plasma volume normally observed in 24h HU rats. The studies proposed examine the integration of neural and humoral factors influencing sodium ingestion in the HU model of bed rest. The specific aims of the study are: Specific aim 1: Investigate the role of the renal nerves in promoting sodium intake during 24 h HU. Specific aim 2: Investigate the role of hormones in promoting sodium intake during HU. Specific aim 3: Examine the role of the cardiac afferent nerves in regulating the intake of sodium. Specific aim 4: Compare short term (24 h) and long term (14 d) effects of HU on sodium ingestion and plasma volume. We hypothesize that increases in renal afferent nerve activity is critical to HU-induced sodium ingestion. Furthermore, elevated aldosterone may contribute to the ingestion of sodium while stimulation of cardiac afferent nerves may inhibit sodium intake in this model. Integration of these signals by the central nervous system results in a modest sodium intake and maintains plasma volume during HU. During prolonged HU, adaptations may occur which further influence both the ingestion of sodium and blood volume. Understanding bed rest and microgravity-induced changes in body fluid balance requires understanding such factors as the acquisition of solutes. It is hoped that these experiments will contribute to an understanding of both the regulation of body fluid during prolonged bed rest and the problems associated with return to normal posture. Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure.

描述(应用程序中的逐字记录)：后肢未称重(HU) 卧床休息和微重力的大鼠模型，Hu导致中枢运动体液、利尿和利钠，导致血浆容量减少。我们观察到，在24小时内，大鼠对生理盐水的摄入量增加。此外，这种生理盐水的摄入抑制了血浆体积的减少通常在HU大鼠24小时内观察。建议的研究检查整合 HU模型中神经和体液因素对钠摄入量的影响卧床休息。这项研究的具体目的是：具体目标1：研究肾神经在促钠作用中的作用 24小时内摄取HU。具体目标2：研究激素在促进钠摄取中的作用在胡的时候。具体目标3：检查心脏传入神经在调节中的作用钠的摄入量。具体目标4：比较HU的短期(24小时)和长期(14天)效果钠摄入量和血浆容量。我们假设肾传入神经活动的增加对 HU诱导的钠摄取。此外，升高的醛固酮可能起到一定作用。在刺激心脏传入神经的同时摄取钠可能在这个模型中抑制钠的摄入。这些信号的集成由中枢神经系统导致适量的钠摄入并维持血浆水平 HU期间的音量。在延长的HU期间，可能会发生进一步的适应对钠的摄取和血容量都有影响。了解卧床休息和微重力引起的体液平衡变化需要了解溶质的获取等因素。希望是这样的这些实验将有助于理解长卧床期间体液的调节及相关问题恢复到正常姿势。此外，这些数据可能有助于了解与人口老龄化有关的健康问题和心血管疾病，如充血性心力衰竭。