Understandings The Immunopathogenesis of Malaria in Latin

了解拉丁语中疟疾的免疫发病机制

• 批准号: 8895249
• 负责人: Myriam Arevalo-Herrera
• 金额: $ 22.44万
• 依托单位: CAUCASECO SCIENTIFIC RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8895249
• 关键词: Acute; American; Anemia; Area; Case Management; Child; Child Development; Child health care; Clinical; Cohort Studies; Colombia; Country; Cross-Sectional Studies; Development; Diagnostic tests; Disease Outcome; Epidemiology; Evaluation; Event; Exposure to; Fetal Growth; Fetus; Future; Growth and Development function; Guatemala; Guidelines; Health; Health Policy; Helminths; Hematological Disease; Immune; Impairment; Individual; Infection; Instruction; International; Intervention; Latin America; Life; Longitudinal Studies; Malaria; Malaria Vaccines; Measures; Mothers; Neonatal; Newborn Infant; Nutritional status; Outcome; Parasitemia; Parasites; Patients; Peru; Plasmodium falciparum; Population; Pregnancy; Prevalence; Questionnaires; Research; Role; Sampling; Sentinel; Severities; Site; Structure; Surveys; Term Birth; Testing; Weight; Woman; base; case control; co-infection; design; experience; immunological status; improved; insight; malaria transmission; prospective; stillbirth; transmission process; vaccine development

PROJECT SUMMARY (See Instructions): The main objective of this project Is to determine the clinical outcomes and their association with parasite and host features of malaria-infected individuals living In non-Amazon regions of Latin America (LA) with different intensities of malaria transmission. It is hypothesized that clinical manifestations of malaria in infected individuals living in high malaria transmission areas are different from those observed in low transmission areas in which both parasites P. vivax and P. falciparum co-exist. These studies will be conducted through the following specific alms: 1) establishment of the clinical profile of malaria In different epidemiological settings and their association with parasite and host immunological status:; 2) assess the prevalence of malaria mixed infections and its influence in the clinical outcomes of the disease; 3) determine the prevalence of hematological manifestations related to malaria infection and their association with concomitant immune status nutritional factors, and helminth co-infections, and 4) determine the prevalence of placental malaria and Its impact on neonatal health and child development. This is a multisite center study in Latin America in which cross-sectional, cohort studies and longitudinal and cohort studies will be performed In 3,600 individuals for alms 1-3 and 200 newborns for aim 4. Parasitological, hematological, and immunological evaluations will be performed and concomitant non-malaria infections will be evaluated. The impact of malaria on child growth and development and level of impairment will be assessed using locally standardized questionnaires based on International guidelines (BMI and ICF). The overall studies proposed in this project will not only provide a better understanding ofthe immunopathogenesis of malaria in LA but will also generate useful Information for malaria case management, control strategies including antimalaria therapy, future use of malaria vaccine and points of intervention to improve developmental outcomes of children living in malaria endemic regions of LA.

项目摘要（请参阅说明）： 该项目的主要目的是确定居住在拉丁美洲非阿马森地区（LA）的疟疾感染者（LA）的临床结果及其与疟疾感染者的寄主特征的关联，并具有不同的疟疾传播强度。假设疟疾在高疟疾传播区域的感染个体的疟疾临床表现与在寄生虫寄生虫和恶性疟原虫共存的低传播区域不同。这些研究将通过以下特定施舍进行：1）在不同的流行病学环境中建立疟疾的临床特征，及其与寄生虫和宿主免疫学地位的关联：； 2）评估疟疾混合感染的流行及其对疾病临床结果的影响； 3）确定与疟疾感染有关的血液学表现的患病率及其与伴随的免疫状况营养因素以及蠕虫共同感染的关联，以及4）确定胎盘疟疾的患病率及其对新生儿健康和儿童发育的影响。这是在拉丁美洲进行的一项多站点中心研究，其中将在3,600个人中对3,600个人进行跨截面，纵向研究和纵向和队列研究，用于ALMS 1-3和200个新生儿。 疟疾对儿童成长和发展以及损害水平的影响将使用基于国际准则（BMI和ICF）的本地标准化问卷进行评估。该项目中提出的总体研究不仅将更好地了解洛杉矶疟疾的免疫发育生成，而且还将为疟疾病例管理提供有用的信息，控制策略，包括抗马利亚治疗，未来对疟疾疫苗的使用以及干预点，以改善洛杉矶玛拉里亚质学院的儿童发育局的发展。