Understandings The Immunopathogenesis of Malaria in Latin

了解拉丁语中疟疾的免疫发病机制

• 批准号: 8895249
• 负责人: Myriam Arevalo-Herrera
• 金额: $ 22.44万
• 依托单位: CAUCASECO SCIENTIFIC RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8895249
• 关键词: Acute; American; Anemia; Area; Case Management; Child; Child Development; Child health care; Clinical; Cohort Studies; Colombia; Country; Cross-Sectional Studies; Development; Diagnostic tests; Disease Outcome; Epidemiology; Evaluation; Event; Exposure to; Fetal Growth; Fetus; Future; Growth and Development function; Guatemala; Guidelines; Health; Health Policy; Helminths; Hematological Disease; Immune; Impairment; Individual; Infection; Instruction; International; Intervention; Latin America; Life; Longitudinal Studies; Malaria; Malaria Vaccines; Measures; Mothers; Neonatal; Newborn Infant; Nutritional status; Outcome; Parasitemia; Parasites; Patients; Peru; Plasmodium falciparum; Population; Pregnancy; Prevalence; Questionnaires; Research; Role; Sampling; Sentinel; Severities; Site; Structure; Surveys; Term Birth; Testing; Weight; Woman; base; case control; co-infection; design; experience; immunological status; improved; insight; malaria transmission; prospective; stillbirth; transmission process; vaccine development

PROJECT SUMMARY (See Instructions): The main objective of this project Is to determine the clinical outcomes and their association with parasite and host features of malaria-infected individuals living In non-Amazon regions of Latin America (LA) with different intensities of malaria transmission. It is hypothesized that clinical manifestations of malaria in infected individuals living in high malaria transmission areas are different from those observed in low transmission areas in which both parasites P. vivax and P. falciparum co-exist. These studies will be conducted through the following specific alms: 1) establishment of the clinical profile of malaria In different epidemiological settings and their association with parasite and host immunological status:; 2) assess the prevalence of malaria mixed infections and its influence in the clinical outcomes of the disease; 3) determine the prevalence of hematological manifestations related to malaria infection and their association with concomitant immune status nutritional factors, and helminth co-infections, and 4) determine the prevalence of placental malaria and Its impact on neonatal health and child development. This is a multisite center study in Latin America in which cross-sectional, cohort studies and longitudinal and cohort studies will be performed In 3,600 individuals for alms 1-3 and 200 newborns for aim 4. Parasitological, hematological, and immunological evaluations will be performed and concomitant non-malaria infections will be evaluated. The impact of malaria on child growth and development and level of impairment will be assessed using locally standardized questionnaires based on International guidelines (BMI and ICF). The overall studies proposed in this project will not only provide a better understanding ofthe immunopathogenesis of malaria in LA but will also generate useful Information for malaria case management, control strategies including antimalaria therapy, future use of malaria vaccine and points of intervention to improve developmental outcomes of children living in malaria endemic regions of LA.

项目摘要（参见说明）： 该项目的主要目标是确定生活在拉丁美洲非亚马逊地区（LA）不同疟疾传播强度的疟疾感染者的临床结果及其与寄生虫和宿主特征的关系。据推测，居住在疟疾高传播地区的感染者的疟疾临床表现与在间日疟原虫和恶性疟原虫共存的低传播地区观察到的疟疾临床表现不同。这些研究将通过以下具体措施进行：1）建立不同流行病学背景下疟疾的临床概况及其与寄生虫和宿主免疫学状态的关系：； 2）评估疟疾混合感染的流行情况及其对疾病临床结果的影响； 3) 确定与疟疾感染相关的血液学表现的患病率及其与伴随免疫状态、营养因素和蠕虫合并感染的关系，以及 4) 确定胎盘疟疾的患病率及其对新生儿健康和儿童发育的影响。这是拉丁美洲的一项多中心研究，其中将对 3,600 名施舍 1-3 的个体和 200 名新生儿进行目标 4 的横断面、队列研究以及纵向和队列研究。将进行寄生虫学、血液学和免疫学评估，并评估伴随的非疟疾感染。 将使用基于国际指南（BMI 和 ICF）的当地标准化问卷来评估疟疾对儿童生长发育和损伤程度的影响。该项目提出的总体研究不仅将更好地了解洛杉矶疟疾的免疫发病机制，还将为疟疾病例管理、包括抗疟疾治疗在内的控制策略、疟疾疫苗的未来使用以及改善洛杉矶疟疾流行地区儿童发育结果的干预要点提供有用的信息。