Understandings The Immunopathogenesis of Malaria in Latin

了解拉丁语中疟疾的免疫发病机制

• 批准号: 8009911
• 负责人: Myriam Arevalo-Herrera
• 金额: $ 30.39万
• 依托单位: CAUCASECO SCIENTIFIC RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009911
• 关键词: Acute; Americas; Anemia; Area; Case Management; Child; Child Development; Child health care; Clinical; Cohort Studies; Colombia; Country; Cross-Sectional Studies; Development; Disease Outcome; Epidemiology; Event; Exposure to; Fetal Growth; Fetus; Future; Goals; Growth and Development function; Guatemala; Guidelines; Health; Health Policy; Helminths; Hematological Disease; Immune; Impairment; Individual; Infection; Instruction; Intervention; Latin America; Life; Malaria; Malaria Vaccines; Measures; Mothers; Neonatal; Newborn Infant; Nutritional status; Outcome; Parasitemia; Parasites; Patients; Peru; Plasmodium falciparum; Pregnancy; Prevalence; Questionnaires; Role; Sampling; Severities; Site; Structure; Surveys; Term Birth; Testing; Weight; Woman; base; case control; design; experience; immunological status; improved; insight; transmission process; vaccine development

PROJECT SUMMARY (See Instructions): The main objective of this project Is to determine the clinical outcomes and their associafion with parasite and host features of malaria-infected individuals living In non-Amazon regions of Lafin America (LA) with different intensities of malaria transmission. It is hypothesized that clinical manifestations of malaria in infected individuals living in high malaria transmission areas are different from those observed in low transriiission areas in which both parasites P. vivax and P. falciparum co-exist. These studies will be conducted through the following specific alms: 1) establishment of the clinical profile of malaria In different epidemiological settings and their association with parasite and host immunological status:; 2) assess the prevalence of malaria mixed infecfions and its influence in the clinical outcomes of the disease; 3) determine the prevalence of hematological manifestafions related to malaria infecfion and their associafion with concomitant immune status nutrifional factors, and helminth co-infections, and 4) determine the prevalence of placental malaria and Its impact on neonatal health and child development. This is a multisite center study in Lafin America in which cross-sectional, cohort studies and longitudinal and cohort studies will be performed In 3,600 individuals for alms 1-3 and 200 newborns for aim 4. Parasitological, hematological, and immunological evaluafions will be performed and concomitant non-malaria infections will be evaluated. The impact of malaria on child growth and development and level of impairment will be assessed using locally standardized quesfionnaires based on Internafional guidelines (BMI and ICF). The overall studies proposed in this project will not only provide a better understanding ofthe immunopathogenesis of malaria in LA but will also generate useful Informafion for malaria case management, control strategies including anfimalaria therapy, future use of malaria vaccine and points of intervention to improve developmental outcomes of children living in malaria endemic regions of LA.

项目摘要（请参阅说明）： 该项目的主要目的是确定居住在拉芬美国非亚马逊地区（LA）的疟疾人感染的人的临床结果及其相关性，并具有不同的疟疾传播。假设在高疟疾传播区域的感染个体中，疟疾的临床表现与在寄生虫寄生虫和恶性疟原虫共存的低跨性别区域的临床表现不同。这些研究将通过以下特定施舍进行：1）在不同的流行病学环境中建立疟疾的临床特征，及其与寄生虫和宿主免疫学地位的关联：； 2）评估疟疾混合不适的患病率及其对疾病临床结果的影响； 3）确定与疟疾相关的血液学表现的患病率及其与伴随的免疫状态营养因素和蠕虫感染的关联，以及4）确定胎盘疟疾的普遍存在及其对新生儿健康和儿童发育的影响。这是美国拉芬（Lafin America）的一项多站点中心研究，其中将在3,600个人中对3,600个个体进行施舍1-3和200个新生儿的纵向研究和队列研究。 疟疾对儿童成长和发育以及损害水平的影响将使用基于国际内部指南（BMI和ICF）的局部标准化问题评估。该项目提出的总体研究不仅将更好地了解洛杉矶疟疾的免疫发病发生，而且还将为疟疾病例管理提供有用的信息，控制策略，包括Anfimalaria治疗，未来使用疟疾疫苗和干预点，以改善LA的疟疾中疟疾地区的儿童发育成果。