Understandings The Immunopathogenesis of Malaria in Latin

了解拉丁语中疟疾的免疫发病机制

• 批准号: 8009911
• 负责人: Myriam Arevalo-Herrera
• 金额: $ 30.39万
• 依托单位: CAUCASECO SCIENTIFIC RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009911
• 关键词: Acute; Americas; Anemia; Area; Case Management; Child; Child Development; Child health care; Clinical; Cohort Studies; Colombia; Country; Cross-Sectional Studies; Development; Disease Outcome; Epidemiology; Event; Exposure to; Fetal Growth; Fetus; Future; Goals; Growth and Development function; Guatemala; Guidelines; Health; Health Policy; Helminths; Hematological Disease; Immune; Impairment; Individual; Infection; Instruction; Intervention; Latin America; Life; Malaria; Malaria Vaccines; Measures; Mothers; Neonatal; Newborn Infant; Nutritional status; Outcome; Parasitemia; Parasites; Patients; Peru; Plasmodium falciparum; Pregnancy; Prevalence; Questionnaires; Role; Sampling; Severities; Site; Structure; Surveys; Term Birth; Testing; Weight; Woman; base; case control; design; experience; immunological status; improved; insight; transmission process; vaccine development

PROJECT SUMMARY (See Instructions): The main objective of this project Is to determine the clinical outcomes and their associafion with parasite and host features of malaria-infected individuals living In non-Amazon regions of Lafin America (LA) with different intensities of malaria transmission. It is hypothesized that clinical manifestations of malaria in infected individuals living in high malaria transmission areas are different from those observed in low transriiission areas in which both parasites P. vivax and P. falciparum co-exist. These studies will be conducted through the following specific alms: 1) establishment of the clinical profile of malaria In different epidemiological settings and their association with parasite and host immunological status:; 2) assess the prevalence of malaria mixed infecfions and its influence in the clinical outcomes of the disease; 3) determine the prevalence of hematological manifestafions related to malaria infecfion and their associafion with concomitant immune status nutrifional factors, and helminth co-infections, and 4) determine the prevalence of placental malaria and Its impact on neonatal health and child development. This is a multisite center study in Lafin America in which cross-sectional, cohort studies and longitudinal and cohort studies will be performed In 3,600 individuals for alms 1-3 and 200 newborns for aim 4. Parasitological, hematological, and immunological evaluafions will be performed and concomitant non-malaria infections will be evaluated. The impact of malaria on child growth and development and level of impairment will be assessed using locally standardized quesfionnaires based on Internafional guidelines (BMI and ICF). The overall studies proposed in this project will not only provide a better understanding ofthe immunopathogenesis of malaria in LA but will also generate useful Informafion for malaria case management, control strategies including anfimalaria therapy, future use of malaria vaccine and points of intervention to improve developmental outcomes of children living in malaria endemic regions of LA.

项目总结（见说明）： 该项目的主要目的是确定临床结果及其与生活在具有不同疟疾传播强度的Lafin America（LA）非亚马逊地区的疟疾感染者的寄生虫和宿主特征的关联。据推测，生活在疟疾高传播地区的感染个体的疟疾临床表现不同于在寄生虫间日疟原虫和恶性疟原虫共存的低传播地区观察到的那些。这些研究将通过以下具体措施进行：1）建立疟疾在不同流行病学环境中的临床特征及其与寄生虫和宿主免疫状态的关系; 2）评估疟疾混合感染的流行率及其对疾病临床结局的影响; 3）确定与疟疾感染相关的血液学表现的患病率及其与伴随的免疫状态营养因素和蠕虫合并感染的关联，以及4）确定胎盘疟疾的流行率及其对新生儿健康和儿童发育的影响。这是一项在Lafin America进行的多中心研究，其中将在3，600名个体中进行横断面、队列研究以及纵向和队列研究，以获得1-3个目标，并在200名新生儿中进行目标4。将进行寄生虫学、血液学和免疫学评价，并评价伴随的非疟疾感染。 将根据国际指南（BMI和ICF），使用当地标准化问卷评估疟疾对儿童生长和发育的影响以及损害程度。本项目提出的总体研究不仅将更好地了解洛杉矶疟疾的免疫发病机制，而且还将为疟疾病例管理、包括抗疟治疗在内的控制策略、疟疾疫苗的未来使用以及改善洛杉矶疟疾流行区儿童发育结果的干预点提供有用的信息。