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Urine Diagnostics for Aspergillosis

Urine Diagnostics for Aspergillosis
曲霉菌病的尿液诊断
批准号:
8832823
负责人:
Kieren A. Marr
金额:
$23.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-02-01 至 2016-05-31

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): Aspergillosis is a severe fungal infection that most frequently involves the lungs in people who have immune deficiency caused by cancer chemotherapy and/or transplantation. Although good drugs are available, establishing a diagnosis is difficult, and late treatment has limited our progress in decreasing morbidity and mortality. We observed that Aspergillus polysaccharide antigens are excreted in urine in animal models and humans with disease. Using a novel monoclonal Ab that detects galactofuranose-containing Aspergillus antigens in urine, we have developed a diagnostic test that relies on lateral flow technology, enabling use at near point-of- care. Results of proof-of-concept studies suggest that this device detects antigens early during the course of disease. This phase I application is developed to address two aims: 1. To determine the performance characteristics of this prototype assay when used as an aid to diagnose suspected infection; and 2. To determine the performance characteristics of this assay when used to screen high-risk patients for early disease. Successful validation of the assay will enable phase II development for use of this novel assay in screening and early treatment strategies.
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Urine Diagnostics for Aspergillosis
  • 批准号:
    9409049
  • 项目类别:
  • 资助金额:
    $100.42万
  • 财政年份:
    2015
  • 负责人:
    Kieren A. Marr
  • 依托单位:
Prospective Cohort Study of Cryptococcosis
  • 批准号:
    8726899
  • 项目类别:
  • 资助金额:
    $66.67万
  • 财政年份:
    2013
  • 负责人:
    Kieren A. Marr
  • 依托单位:
Prospective Cohort Study of Cryptococcosis
  • 批准号:
    8903756
  • 项目类别:
  • 资助金额:
    $65.55万
  • 财政年份:
    2013
  • 负责人:
    Kieren A. Marr
  • 依托单位:
Prospective Cohort Study of Cryptococcosis
  • 批准号:
    8639709
  • 项目类别:
  • 资助金额:
    $62.18万
  • 财政年份:
    2013
  • 负责人:
    Kieren A. Marr
  • 依托单位:
海外基金