Patient Oriented Research in Transplant and Oncology ID

移植和肿瘤学 ID 领域以患者为导向的研究

• 批准号: 8652943
• 负责人: Kieren A. Marr
• 金额: $ 19.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8652943
• 关键词: Academic Training; Address; Algorithms; Antifungal Agents; Area; Aspergillosis; Aspergillus; Aspergillus fumigatus; Award; Biological; Biology; Cancer Patient; Candidiasis; Caring; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clostridium difficile; Cohort Studies; Combined Modality Therapy; Communicable Diseases; Computerized Medical Record; Cystic Fibrosis; Data; Databases; Development; Diagnostic; Diagnostic tests; Diarrhea; Disease; Education; Educational Curriculum; Educational process of instructing; Elements; Epidemiology; Exhibits; Faculty; Future; Goals; Grant; Growth; Immune; Industry; Infection; Infection Control; Intervention; Laboratory Study; Leadership; Measures; Mentors; Mentorship; Morbidity - disease rate; Mycoses; Natural Immunity; Organ Transplantation; Outcome; Patients; Performance; Population; Predisposition; Prevention; Prevention and Treatment of Opportunistic Infection; Prevention therapy; Records; Relapse; Research; Research Infrastructure; Research Support; Resources; Scientist; Solid; Source; Structure; Supportive care; Therapeutic; Time; Training; Training Programs; Translational Research; Transplant Recipients; Transplantation; United States National Institutes of Health; Universities; cancer care; career; cohort; cystic fibrosis patients; cytotoxic; design; graduate student; high risk; infectious disease treatment; macrophage; medical schools; multidisciplinary; next generation; oncology; patient oriented research; patient population; programs; public health relevance; reconstitution; therapy duration; translational study; treatment strategy; trend

DESCRIPTION (provided by applicant): This is a proposal for a K24 Mid-career award in Patient-oriented research (POR) for Kieren A. Marr MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the large goal of enabling leadership of this newly developed academic Transplant and Oncology ID program, with immediate goals of building an infrastructure to allow for structured teaching and research on infectious complications and initiating new directions of institutional research. The principal aims are to: 1. Develop a comprehensive academic training program for clinical and translational research in Transplant and Oncology Infectious Diseases; and 2. Define trends in epidemiology and ID outcomes by performing a prospectively maintained dynamic cohort study and building a database that combines elements from transplant and oncology databases, infection control records, and electronic medical records. As part of aim 2, new projects will be established to define the epidemiology and outcomes of Clostridium difficile infection in oncology patients, and to define infectious complications in high-risk recipients of solid organ transplants. These aims will be addressed in the context of providing mentorship to new and existing junior faculty, and to fellows and graduate students. The K24 will allow for Dr. Marr to more effectively pursue her long-term career goals of developing a "world-class" academic program at Johns Hopkins that specializes in the unique ID care of transplant and oncology patients, and building a multidisciplinary translational clinical research program focused on prevention and treatment of opportunistic infections. Public Health Relevance Statement: This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a "world-class" academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.

描述（由申请人提供）：这是Kieren A在面向患者的研究（POR）中获得K24职业中期奖的提案。约翰霍普金斯大学（JHU）医学院的医学博士马尔说。马尔博士最近成为JHU传染病部移植和肿瘤学传染病项目主任。该奖项支持这一新开发的学术移植和肿瘤学ID计划的领导力的大目标，其直接目标是建立一个基础设施，以允许对感染并发症进行结构化的教学和研究，并启动机构研究的新方向。主要目标是：1.为移植和肿瘤学传染病的临床和转化研究制定全面的学术培训计划; 2.通过进行前瞻性动态队列研究，并建立一个结合移植和肿瘤学数据库、感染控制记录和电子病历元素的数据库，确定流行病学和ID结局的趋势。作为目标2的一部分，将建立新的项目，以确定肿瘤患者艰难梭菌感染的流行病学和结局，并确定实体器官移植高风险接受者的感染并发症。这些目标将在为新的和现有的初级教师，研究员和研究生提供指导的背景下解决。K24将使马尔博士能够更有效地追求她的长期职业目标，即在约翰霍普金斯大学开发一个“世界级”的学术项目，专门从事移植和肿瘤患者的独特ID护理，并建立一个多学科的转化临床研究项目，重点是预防和治疗机会性感染。 公共卫生相关性声明：这是Kieren A在患者研究中获得职业中期奖的提案。约翰霍普金斯大学医学院的医学博士马尔说。马尔博士最近成为JHU传染病部移植和肿瘤学传染病项目主任。该奖项支持在约翰霍普金斯发展一个“世界级”学术项目的目标，该项目专门从事器官移植和癌症患者的护理，并建立一个专注于预防和治疗传染病的研究项目。

项目成果

Cryptococcus neoformans prosthetic joint infection: case report and review of the literature.

新型隐球菌假体关节感染：病例报告及文献复习。

• DOI: 10.1007/s11046-014-9847-0
• 发表时间: 2015
• 期刊: Mycopathologia
• 影响因子: 5.5
• 作者: Shah,NeelB;Shoham,Shmuel;Nayak,Seema
• 通讯作者: Nayak,Seema

Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: a 10-year, single-center experience.

• DOI: 10.1111/tid.12060
• 发表时间: 2013-06
• 期刊: Transplant infectious disease : an official journal of the Transplantation Society
• 作者: Neofytos D;Treadway S;Ostrander D;Alonso CD;Dierberg KL;Nussenblatt V;Durand CM;Thompson CB;Marr KA
• 通讯作者: Marr KA

Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.

肾移植受者中艰难梭菌感染的流行病学，危险因素和结果。

• DOI: 10.1111/tid.12030
• 发表时间: 2013-04
• 期刊: Transplant infectious disease : an official journal of the Transplantation Society
• 作者: Neofytos D;Kobayashi K;Alonso CD;Cady-Reh J;Lepley D;Harris M;Desai N;Kraus E;Subramanian A;Treadway S;Ostrander D;Thompson C;Marr K
• 通讯作者: Marr K

Outcomes in Transplant Recipients Treated With Foscarnet for Ganciclovir-Resistant or Refractory Cytomegalovirus Infection.

• DOI: 10.1097/tp.0000000000001418
• 发表时间: 2016-10
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: Avery RK;Arav-Boger R;Marr KA;Kraus E;Shoham S;Lees L;Trollinger B;Shah P;Ambinder R;Neofytos D;Ostrander D;Forman M;Valsamakis A
• 通讯作者: Valsamakis A

Recurrent Events Analysis With Data Collected at Informative Clinical Visits in Electronic Health Records.

• DOI: 10.1080/01621459.2020.1801447
• 发表时间: 2021
• 期刊: Journal of the American Statistical Association
• 影响因子: 3.7
• 作者: Sun Y;McCulloch CE;Marr KA;Huang CY
• 通讯作者: Huang CY