Patient Oriented Research in Transplant and Oncology ID

描述（由申请人提供）：这是为约翰霍普金斯大学（JHU）医学院的Kieren a . Marr MD申请K24面向患者研究（POR）职业中期奖的提案。Marr博士最近成为JHU传染病部移植和肿瘤传染病项目主任。该奖项旨在支持该新开发的移植和肿瘤学学术ID项目的领导地位，其近期目标是建立基础设施，以便在感染并发症方面进行结构化教学和研究，并启动机构研究的新方向。主要目的是：1。为移植和肿瘤传染病的临床和转化研究制定全面的学术培训计划；和2。通过开展前瞻性的动态队列研究，并建立一个结合移植和肿瘤学数据库、感染控制记录和电子医疗记录元素的数据库，确定流行病学和ID结果的趋势。作为目标2的一部分，将建立新的项目，以确定肿瘤患者中艰难梭菌感染的流行病学和结果，并确定实体器官移植高危受体的感染并发症。这些目标将在为新的和现有的初级教师、研究员和研究生提供指导的背景下得到解决。K24将使Marr博士能够更有效地追求她的长期职业目标，即在约翰霍普金斯大学开发一个“世界级”的学术项目，专门研究移植和肿瘤患者的独特ID护理，并建立一个多学科的转化临床研究项目，专注于预防和治疗机会性感染。

DESCRIPTION (provided by applicant): This is a proposal for a K24 Mid-career award in Patient-oriented research (POR) for Kieren A. Marr MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the large goal of enabling leadership of this newly developed academic Transplant and Oncology ID program, with immediate goals of building an infrastructure to allow for structured teaching and research on infectious complications and initiating new directions of institutional research. The principal aims are to: 1. Develop a comprehensive academic training program for clinical and translational research in Transplant and Oncology Infectious Diseases; and 2. Define trends in epidemiology and ID outcomes by performing a prospectively maintained dynamic cohort study and building a database that combines elements from transplant and oncology databases, infection control records, and electronic medical records. As part of aim 2, new projects will be established to define the epidemiology and outcomes of Clostridium difficile infection in oncology patients, and to define infectious complications in high-risk recipients of solid organ transplants. These aims will be addressed in the context of providing mentorship to new and existing junior faculty, and to fellows and graduate students. The K24 will allow for Dr. Marr to more effectively pursue her long-term career goals of developing a "world-class" academic program at Johns Hopkins that specializes in the unique ID care of transplant and oncology patients, and building a multidisciplinary translational clinical research program focused on prevention and treatment of opportunistic infections. Public Health Relevance Statement: This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a "world-class" academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.