Patient Oriented Research in Transplant and Oncology ID

描述(由申请人提供)：这是为约翰霍普金斯大学(JHU)医学院的Kieren A.Marr医学博士提供的K24以患者为中心的研究(POR)职业中期奖的建议。Marr博士最近成为JHU传染病科移植和肿瘤学传染病项目的主任。该奖项支持这个新开发的学术移植和肿瘤学ID项目的领导地位的大目标，近期目标是建立一个基础设施，以允许在感染并发症方面进行结构化的教学和研究，并启动机构研究的新方向。其主要目标是：1.为移植和肿瘤学传染病的临床和转化性研究制定一个全面的学术培训计划；以及2.通过执行一项预期维持的动态队列研究，并建立一个结合移植和肿瘤学数据库、感染控制记录和电子医疗记录的数据库，确定流行病学和身份识别结果的趋势。作为目标2的一部分，将建立新的项目，以确定肿瘤患者中艰难梭菌感染的流行病学和结果，并确定固体器官移植的高风险接受者的感染并发症。这些目标将在向新的和现有的初级教员以及研究员和研究生提供指导的背景下加以解决。K24将使Marr博士能够更有效地实现她的长期职业目标，即在约翰·霍普金斯大学开发一个专门研究移植和肿瘤患者独特ID护理的“世界级”学术项目，并建立一个专注于预防和治疗机会性感染的多学科转化性临床研究项目。 公共卫生相关声明：这是为约翰霍普金斯大学(JHU)医学院的Kieren A.Marr医学博士设立的患者研究生涯中期奖的建议。Marr博士最近成为JHU传染病科移植和肿瘤学传染病项目的主任。该奖项支持约翰·霍普金斯大学建立一个专门从事器官移植和癌症患者护理的“世界级”学术项目的目标，并建立一个专注于预防和治疗传染病的研究项目。

DESCRIPTION (provided by applicant): This is a proposal for a K24 Mid-career award in Patient-oriented research (POR) for Kieren A. Marr MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the large goal of enabling leadership of this newly developed academic Transplant and Oncology ID program, with immediate goals of building an infrastructure to allow for structured teaching and research on infectious complications and initiating new directions of institutional research. The principal aims are to: 1. Develop a comprehensive academic training program for clinical and translational research in Transplant and Oncology Infectious Diseases; and 2. Define trends in epidemiology and ID outcomes by performing a prospectively maintained dynamic cohort study and building a database that combines elements from transplant and oncology databases, infection control records, and electronic medical records. As part of aim 2, new projects will be established to define the epidemiology and outcomes of Clostridium difficile infection in oncology patients, and to define infectious complications in high-risk recipients of solid organ transplants. These aims will be addressed in the context of providing mentorship to new and existing junior faculty, and to fellows and graduate students. The K24 will allow for Dr. Marr to more effectively pursue her long-term career goals of developing a "world-class" academic program at Johns Hopkins that specializes in the unique ID care of transplant and oncology patients, and building a multidisciplinary translational clinical research program focused on prevention and treatment of opportunistic infections. Public Health Relevance Statement: This is a proposal for a Mid-career award in patient research for Kieren A. Marr, MD, of the Johns Hopkins University (JHU) School of Medicine. Dr. Marr recently became the Director of the Transplant and Oncology Infectious Diseases Program in the Division of Infectious Diseases at JHU. The award supports the goal of developing a "world-class" academic program at Johns Hopkins that specializes in the care of organ transplant and cancer patients, and building a research program focused on prevention and treatment of infectious diseases.