Dementia Caregiver Rehabilitation: Enhancing Veteran and Family-Centered Care

产品说明： 这是一份为Blake Scanlon博士申请CDA-2奖的申请，他是VA帕洛阿尔托医疗保健系统Sierra- Pacific精神疾病研究、教育和临床中心（MIRECC）的老龄化/痴呆研究员。斯坎伦博士正在建立自己作为一个临床科学家谁进行退伍军人和家庭为中心的痴呆症和神经退行性疾病的临床研究。该CDA-2奖项将为Scanlon博士提供必要的支持和指导，以实现以下目标：1）发展Scanlon博士在康复干预方面的技能; 2）加强他在临床试验和转化科学方面的培训; 3）通过更先进的方法学培训增强他在纵向数据分析方面的基本技能; 4）扩大他的专业知识，包括通过先进的技术，包括视频远程医疗提供教育和技能建设;和5）为博士提供必要的培训机会和指导斯坎隆发展为一个独立的临床研究者在VA。为了实现这些目标，斯坎伦博士组建了一个指导团队，其中包括一位主要导师：杰罗姆耶萨维奇博士（老年精神病学家和认知和精神功能在整个生命周期的著名专家）;两位共同导师：乔伊·泰勒博士（认知心理学家和认知衰退轨迹专家）和丽莎木下博士（一名临床神经心理学家，擅长评估和治疗痴呆症的认知和行为症状）;以及三名顾问：[[玛丽·米特尔曼博士（国际知名的痴呆症护理干预专家）]]，Booil Jo博士（一位生物统计学家，擅长临床trias的设计/分析、纵向数据分析和缺失数据分析）和Betty Wexler女士（一位临床护理专家，擅长痴呆症和家庭护理）。拟议的项目研究教育和技能建设康复干预的效果，旨在降低成本， 临床上可通过视频远程医疗翻译，对痴呆症退伍军人的家庭照顾者。干预效果将在干预后6个月、12个月和24个月进行纵向检查。Scanlon博士将使用先进的统计技术来确定干预对以下方面的影响：老年痴呆症退伍军人护理人员的生活质量（主要目标1），护理人员的抑郁症状（次要目标2），以及社区任期，长期护理安置时间和生存率（次要目标3）。拟议的研究将利用MIRECC的基础设施来调查这种护理人员干预的创新方法。该奖项将创造一个理想的环境，使Scanlon博士能够将全部时间集中在以退伍军人和家庭为中心的临床研究上，并使他能够追求他的长期职业目标：开发一个完全独立的研究计划，调查低成本，务实和临床可翻译的方法，以改善神经退行性疾病和痴呆症的康复和管理。

DESCRIPTION: This is an application for a CDA-2 award for Dr. Blake Scanlon, an aging/dementia fellow in the Sierra- Pacific Mental Illness Research, Education, and Clinical Center (MIRECC) at the VA Palo Alto Health Care System. Dr. Scanlon is establishing himself as a clinician-scientist who conducts Veteran- and family- centered clinical research on dementia and neurodegenerative disease. This CDA-2 award will provide Dr. Scanlon with the support and mentorship necessary to achieve the following goals: 1) develop Dr. Scanlon's skills in rehabilitative intervention; 2) enhance his training in clinical trials and translational science; 3) augment his basic skills in longitudinal data analysis with more advanced methodological training; 4) expand his expertise to include the provision of education and skill-building through advancing technologies including video telehealth; and 5) provide Dr. Scanlon the necessary training opportunities and mentorship to develop as an independent clinical investigator in VA. To accomplish these goals, Dr. Scanlon has gathered a mentoring team that includes one primary mentor: Dr. Jerome Yesavage (a geriatric psychiatrist and renowned expert in cognitive and psychiatric functioning across the lifespan); two co-mentors: Dr. Joy Taylor (a cognitive psychologist and expert in the trajectory of cognitive decline) and Dr. Lisa Kinoshita (a clinical neuropsychologist with expertis in the assessment and treatment of cognitive and behavioral symptoms in dementia); and three consultants: [[Dr. Mary Mittelman (an internationally renowned expert in dementia caregiver intervention)]], Dr. Booil Jo (a biostatistician with expertise in design/analysis of clinical trias, longitudinal data analysis, and missing data analysis), and Ms. Betty Wexler (a clinical nurse specialist with expertise in dementia and family caregiving). The proposed project studies the effects of an education and skill-building rehabilitation intervention, designed to be low-cost and clinically translatable through video telehealth, on family caregivers of Veterans with dementia. Intervention effects will be examined longitudinally at six, 12, and 24 months post-intervention. Dr. Scanlon will use advanced statistical techniques to determine the impact of the intervention on: quality of life in caregivers of Veterans with dementia (Primary Aim 1), depressive symptoms in caregivers (Secondary Aim 2), and community tenure, time to long-term care placement, and survival (Secondary Aim 3). The proposed study will utilize the infrastructure of the MIRECC to investigate this innovative method of caregiver intervention. This award would create an ideal environment where Dr. Scanlon could wholly focus his time on Veteran- and family-centered clinical research and would enable him to pursue his long-term career objective: developing a fully independent research program investigating low-cost, pragmatic and clinically translatable methods for improving rehabilitation and management of neurodegenerative disease and dementia.