Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG

描述（申请人提供）：器官移植和癌症化疗是越来越多患者的救命手段。尽管在手术技术、免疫抑制方案和新型抗菌药物的开发方面取得了重大进展，但这些免疫功能低下的宿主仍然面临发生感染的巨大风险。照顾这个复杂的病人群体需要独特的知识，不同于一般的传染病临床医生。因此，移植传染病已经成为传染病（ID）领域的一个亚专业，美国移植学会已经制定了一个培训移植传染病专家的核心课程。杜克大学是唯一准备为研究员提供移植ID的特殊培训：杜克大学医院是一个主要的移植和癌症护理中心，拥有活跃的移植/免疫受损主机ID服务，acgme认证的ID和医学微生物学培训计划，以及高素质的教师致力于在移植ID的专业领域教授研究员，包括最先进的基础科学方法和以患者为导向的研究。事实上，在过去的10年里，杜克大学的ID部门已经培养了几位成功的年轻教师，他们目前担任学术职位，专门从事移植ID的护理和研究。该培训计划的目标是利用杜克大学丰富的资源，以开发在免疫功能低下宿主护理和最新研究方法方面受过培训的创新ID医生科学家。联合研究和临床培训计划将在完成至少一年的普通临床ID奖学金后进行，其中将包括基线移植ID经验。移植ID核心课程将包括移植/免疫功能低下宿主临床护理的额外培训，与移植ID相关的实验室医学培训，以及根据学员的专业知识和职业目标个性化的基础或临床研究技能的发展。研究培训的关键领域，适用于移植/免疫功能低下的宿主，将包括：1)检验医学，2)微生物流行病学和发病机制，3)宿主对感染的易感性和反应，以及4)医疗管理和治疗结果。

DESCRIPTION (provided by applicant):Organ transplantation and cancer chemotherapy are life-saving interventions for an increasing number of patients. Despite important advances in surgical technique, immunosuppressive regimens, and the development of novel antimicrobial agents, these immunocompromised hosts remain at substantial risk for developing infections. Care of this complex patient population requires unique knowledge that differs from that of the general Infectious Diseases clinician. Accordingly, Transplant Infectious Diseases has emerged as a subspecialty within the field of Infectious Diseases (ID), and the American Society of Transplantation has developed a core curriculum for training specialists in Transplant ID. Duke University is uniquely poised to provide fellows with exceptional training in Transplant ID: Duke University Hospital is a major transplant and cancer care center with an active Transplant/Immunocompromised Host ID Service, ACGME-accredited Training Programs in ID and Medical Microbiology, and a highly qualified faculty committed to teaching fellows in the specialized area of Transplant ID including state-of-the-art methods of basic science and patient- oriented research. In fact, with minimal support over the past 10 years, the Duke ID Division has trained several successful young faculty who currently hold academic positions, specializing in Transplant ID care and research. The objective of this Training Program is to capitalize on the rich resources available at Duke in order to develop innovative ID physician-scientists trained in the care of immunocompromised hosts and the latest research methods. The combined research and clinical training program will occur after completion of at least one year of general clinical ID fellowship, which will include baseline Transplant ID experience. The Transplant ID core curriculum will include additional training in the clinical care of the transplant/immunocompromised host, training in laboratory medicine relevant to Transplant ID, and development of either basic or clinical research skills individualized to the trainee's expertise and career goals. Key areas for research training, as applicable to the Transplant/Immunocompromised host, will include: 1) laboratory medicine, 2) microbial epidemiology & pathogenesis, 3) host susceptibility & response to infection, and 4) medical management & treatment outcomes.