Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG

描述(申请人提供)：器官移植和癌症化疗是越来越多的患者的救命干预措施。尽管外科技术、免疫抑制疗法和新型抗菌剂的开发取得了重要进展，但这些免疫受损的宿主仍然面临着发生感染的巨大风险。护理这一复杂的患者群体需要不同于普通传染病临床医生的独特知识。因此，移植传染病已经成为传染病(ID)领域的一个子专业，美国移植学会已经开发了一项核心课程，用于培训移植ID专家。杜克大学是唯一准备为研究员提供移植ID方面的特殊培训的大学：杜克大学医院是一家主要的移植和癌症护理中心，拥有活跃的移植/免疫受损宿主ID服务，ACGME认证的ID和医学微生物学培训计划，以及一支致力于教授移植ID专门领域研究员的高资质教员，包括最先进的基础科学方法和以患者为导向的研究。事实上，在过去10年里，在最少的支持下，杜克大学ID部门已经培训了几名成功的年轻教师，他们目前担任学术职位，专门从事移植ID护理和研究。这一培训计划的目标是利用杜克大学丰富的资源，培养创新的ID内科医生--接受过免疫缺陷宿主护理和最新研究方法培训的科学家。合并的研究和临床培训计划将在完成至少一年的普通临床ID奖学金后进行，其中将包括基线移植ID经验。移植ID核心课程将包括移植/免疫缺陷宿主的临床护理方面的额外培训，与移植ID相关的实验室医学培训，以及根据受训者的专业知识和职业目标发展个性化的基础或临床研究技能。适用于移植/免疫受损宿主的研究培训的关键领域包括：1)实验室医学，2)微生物流行病学和发病机制，3)宿主易感性和对感染的反应，以及4)医疗管理和治疗结果。

DESCRIPTION (provided by applicant):Organ transplantation and cancer chemotherapy are life-saving interventions for an increasing number of patients. Despite important advances in surgical technique, immunosuppressive regimens, and the development of novel antimicrobial agents, these immunocompromised hosts remain at substantial risk for developing infections. Care of this complex patient population requires unique knowledge that differs from that of the general Infectious Diseases clinician. Accordingly, Transplant Infectious Diseases has emerged as a subspecialty within the field of Infectious Diseases (ID), and the American Society of Transplantation has developed a core curriculum for training specialists in Transplant ID. Duke University is uniquely poised to provide fellows with exceptional training in Transplant ID: Duke University Hospital is a major transplant and cancer care center with an active Transplant/Immunocompromised Host ID Service, ACGME-accredited Training Programs in ID and Medical Microbiology, and a highly qualified faculty committed to teaching fellows in the specialized area of Transplant ID including state-of-the-art methods of basic science and patient- oriented research. In fact, with minimal support over the past 10 years, the Duke ID Division has trained several successful young faculty who currently hold academic positions, specializing in Transplant ID care and research. The objective of this Training Program is to capitalize on the rich resources available at Duke in order to develop innovative ID physician-scientists trained in the care of immunocompromised hosts and the latest research methods. The combined research and clinical training program will occur after completion of at least one year of general clinical ID fellowship, which will include baseline Transplant ID experience. The Transplant ID core curriculum will include additional training in the clinical care of the transplant/immunocompromised host, training in laboratory medicine relevant to Transplant ID, and development of either basic or clinical research skills individualized to the trainee's expertise and career goals. Key areas for research training, as applicable to the Transplant/Immunocompromised host, will include: 1) laboratory medicine, 2) microbial epidemiology & pathogenesis, 3) host susceptibility & response to infection, and 4) medical management & treatment outcomes.