Transplant Infectious Diseases Interdisciplinary Research Training Grant

移植传染病跨学科研究培训补助金

• 批准号: 10441317
• 负责人: BARBARA D ALEXANDER
• 金额: $ 5.35万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441317
• 关键词: Communicable Diseases; Grant; Interdisciplinary Study; Research Training; Transplantation

The Duke Transplant Infectious Diseases Training Program (TxIDTP) identifies talented young physicians knowledgeable in the clinical aspects of Infectious Diseases (ID) and provides them with advanced training in innovative methods of scientific research and the clinical care of the Transplant/Immunocompromised Host (ICH). Organ transplantation and cancer chemotherapy are life-saving interventions for an increasing number of patients. And while advances in surgical technique, cancer chemotherapy, and immunosuppressive drugs have improved the prognosis of transplant and hematologic malignancy patients, the majority of survivors remain at substantial risk for infection. Care of the complex ICH requires unique knowledge that differs from that of the general ID clinician; consequently, Transplant ID (TxID) has emerged as a subspecialty within ID. Further, physician-scientists, capable of bridging the link between medical research and clinical practice, are absolutely critical to understanding the epidemiology, unraveling the pathogenesis, improving the diagnosis, developing evidenced-based prevention and treatment plans, and responding to new infectious challenges as they emerge for this population. Duke University is uniquely poised to train such TxID physician-scientists. Duke Hospital is a major transplant and cancer care center with an active TxID clinical service, ACGME-accredited training programs in ID and Medical Microbiology, and a highly qualified faculty equipped and committed to teaching state- of-the-art methods of basic science and clinical/translational research. The objective of the TxIDTP is to capitalize on the rich resources available at Duke in order to develop innovative TxID physician-scientists. The combined research and clinical training occurs after completion of at least one year of general clinical ID fellowship. The program enrolls one new trainee per year and each trainee completes 3 years of training. The core curriculum includes training in the clinical care of the ICH and either basic or clinical/translational research individualized to the trainee's career goals. Key areas for research training, as applicable to the ICH, include: 1) microbial epidemiology and pathogenesis, 2) laboratory medicine, 3) host susceptibility and response to infection, and 4) medical management and treatment outcomes. Advanced degree options (e.g., Masters in Health Science) are available through the TxIDTP.

杜克大学移植传染病培训计划(TxIDTP)确定了有才华的年轻医生 了解传染病(ID)的临床方面，并为他们提供以下高级培训 移植/免疫缺陷宿主的创新科研方法和临床护理 (ICH)。器官移植和癌症化疗是越来越多的人的救命干预措施 病人。虽然外科技术、癌症化疗和免疫抑制药物的进步 改善移植和血液系统恶性肿瘤患者的预后，大多数幸存者仍在 感染的风险很大。治疗复杂的脑出血需要独特的知识，不同于 普通ID临床医生；因此，移植ID(TxID)已成为ID中的一个子专业。此外， 能够在医学研究和临床实践之间架起桥梁的内科科学家绝对是 对了解流行病学、解开发病机制、提高诊断、发展至关重要 以证据为基础的预防和治疗计划，并在新的传染病挑战出现时予以应对 对这群人来说。杜克大学是唯一准备培养这样的TxID内科医生和科学家的大学。杜克医院是一家 主要的移植和癌症护理中心，提供积极的TxID临床服务，ACGME认证的培训 ID和医学微生物学课程，以及一支配备并致力于教学的高素质教师队伍- 基础科学和临床/转化性研究的最先进方法。TxIDTP的目标是利用 关于杜克大学丰富的可用资源，以培养创新的TxID医生-科学家。合并后的 研究和临床培训在完成至少一年的普通临床ID奖学金后进行。这个 该计划每年招收一名新学员，每个学员完成3年的培训。核心课程 包括ICH临床护理方面的培训，以及个性化的基础或临床/转化性研究 实习生的职业目标。适用于非物质文化遗产的研究培训的关键领域包括：1)微生物 流行病学和发病机制，2)实验室医学，3)宿主易感性和对感染的反应，4) 医疗管理和治疗结果。高级学位选项(例如，健康科学硕士)有 可通过TxIDTP获得。

项目成果

SIDEBAR: Orange County, NC Interdisciplinary "Strike Team" Supports High-Risk Congregate Living Facilities in COVID-19 Response.

• DOI: 10.18043/ncm.82.1.58
• 发表时间: 2021-01
• 期刊: North Carolina medical journal
• 作者: Pease RC;Keen SK;Coleman GC;Pettigrew EM;Porterfield DS
• 通讯作者: Porterfield DS

Donor and transplant candidate selection for solid organ transplantation during the COVID-19 pandemic.

• DOI: 10.1111/ajt.16138
• 发表时间: 2020-11
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Impact of Location of Acquisition of Gram-Positive Bloodstream Infections on Clinical Outcomes Among Patients Admitted to Community Hospitals.

获得革兰氏阳性血流感染的地点对社区医院患者临床结果的影响。

• DOI: 10.2147/idr.s259185
• 发表时间: 2020
• 期刊: Infection and drug resistance
• 影响因子: 3.9
• 作者: Messina,JuliaA;Moehring,RebekahW;Schmader,KennethE;Anderson,DeverickJ
• 通讯作者: Anderson,DeverickJ

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

• DOI: 10.1016/j.healun.2022.06.018
• 发表时间: 2022-10
• 期刊: JOURNAL OF HEART AND LUNG TRANSPLANTATION
• 影响因子: 8.9
• 作者: Eichenberger, Emily M.;Coniglio, Amanda C.;Milano, Carmelo;Schroder, Jacob;Bryner, Benjamin S.;Spencer, Philip J.;Haney, John C.;Klapper, Jacob;Glass, Carolyn;Pavlisko, Elizabeth;Dibernardo, Louis;Patel, Chetan B.;DeVore, Adam D.;Reynolds, John;Wolfe, Cameron R.
• 通讯作者: Wolfe, Cameron R.

Donor evaluation in the era of HIV-positive organ transplantation: The importance of the infectious diseases specialist.

• DOI: 10.1111/ajt.15921
• 发表时间: 2020-09
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Hemmersbach-Miller M;Wood RP;Wolfe CR
• 通讯作者: Wolfe CR