Peru Infectious Diseases Epidemiology Research Training Consortium

 描述(由申请人提供)：南美洲面临不断变化的流行病环境，既有地方性挑战，也有新出现的挑战。过去的挑战涵盖了从SARS到禽流感和大流行性流感以及登革出血热等各种疾病。我们现在受到即将出现的基孔肯雅病毒、圭亚那盾牌中抗青蒿素恶性疟原虫的上升以及南锥体内脏利什曼病传播的威胁。要对新出现的感染作出适当反应，流行病学家需要接受高级研究培训。然而，在秘鲁这样的资源有限的国家，没有国际水平的博士项目。NAMRU-6/UPCH/UNMSM/UFMG/JHBSPH/USUHS/CDC联盟建议大幅扩大我们以具有成本效益和可持续的方式培训博士级研究人员的能力，培养新一代国际水平的科学家。具体地说，我们将在秘鲁建立一个为期四年的流行病学博士课程，并将招收两个四人班。此外，我们将在完成课程后重新插入秘鲁的七名博士生/毕业生，同时另外七名博士生/毕业生将进入世界级项目。我们的巴西合作伙伴将被证明是至关重要的 在这项活动中。我们将再增加90名可自我维持的流行病学硕士项目的毕业生，其中约25%从事传染病研究，约20%在公共部门工作。最后，我们将在短期研究方法课程或实验室/实地轮换方面培训200名本科生，为新一代科学家奠定基础。 在秘鲁，谁能够解决新出现的和寄生虫感染的控制问题。我们的方法的可行性得到了我们在以往获奖期间取得的良好成绩的支持。我们为8名秘鲁科学家提供了国际博士培训，又有5名硕士毕业生开始攻读博士学位。此外，我们还提供了我们的硕士项目连续七年培训184名拉美学生。我们联盟发表了60篇论文，我们的硕士研究生毕业后发表了152篇论文，与培训前相比，他们每年的论文发表速度重复了一倍。展望未来，来自国防部的有竞争力的研究资金将是为我们的学员提供长期职业可持续性的关键。培训将在一个由国防部和美国国立卫生研究院在广泛的多年研究项目中的合作支持的ICH环境中进行。我们的提议得到了大量训练有素的本地和外国导师、先进的实验室以及不同的现场和临床地点的支持：45个组织、32名永久居住在秘鲁的博士科学家和116份支持文件，这是一个坚实的区域合作。

 DESCRIPTION (provided by applicant): South America faces a changing epidemiological environment with a mix of endemic and emerging challenges. Past challenges have covered a broad range of ailments moving from SARS to avian and pandemic influenza and dengue hemorrhagic fever. We are now threatened by the imminent emergence of Chikungunya virus, the rise of artemisinin-resistant Plasmodium falciparum in the Guyana shield and the spread of visceral leishmaniasis in the southern cone. An adequate response to emerging infections requires epidemiologists with advanced research training. However, there are no doctoral programs of international caliber in resource- limited countries like Peru. The NAMRU-6/UPCH/UNMSM/UFMG/JHBSPH/USUHS/CDC consortium proposes to substantially expand our ability to train doctoral-level investigators in a cost-effective and sustainable way, fosterin a new generation of international-caliber scientists. Specifically, we will create a four-year doctorl program in Epidemiology in Peru and will enroll two four-student classes. Additionally, we will reinsert seven PhDs scientists in Peru upon completion of coursework while another seven PhD students/graduates enroll in world-class programs. Our Brazilian partners will prove to be critical for this activity. We will add another 90 graduates from our self-sustainable Epidemiology Masters' program, ~25% conducting infectious diseases research and ~20% working in the public sector. Finally, we will train 200 undergraduate students in short research methods courses or laboratory/field rotations to establish the foundation of a new generation of scientists in Peru who can address the control of emerging and parasitic infections. The viability of our approach is supported by our substantial track record accomplished during our previous awards. We have provided international doctoral training for eight Peruvian scientists and five additional Masters' graduates have started doctoral coursework. Furthermore, we have offered our Masters' program seven years in a row training 184 Latin American students. Our consortium has published 60 papers and our Masters' students have produced 152 papers after graduation, duplicating their rate of articles published per year as compared to before their training. Moving forward, competitive research funding from the Department of Defense will be critical to provide long-term career sustainability to our trainees. Training will take place in a ich environment supported by DoD and NIH collaborations in extensive multi-year research projects. Our proposal is supported by a large pool of highly trained local and foreign mentors, sophisticated laboratories, and diverse field and clinical sites: 45 organizations, 32 PhD scientists residing permanently in Peru and 116 letters of support documents a solid regional collaboration.