Development and Homeostasis of Skeletal Muscle in Health and Disease

健康和疾病中骨骼肌的发育和稳态

• 批准号: 8982136
• 负责人: Steven Burden
• 金额: $ 2.1万
• 依托单位: SOCIETY FOR MUSCLE BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8982136
• 关键词: Address; Adult; Age; Animal Model; Architecture; Area; Attention; Autoimmune Process; Awareness; Biological; Biology; California; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Connective Tissue; Development; Developmental Biology; Developmental Process; Disease; Elderly; Endocrine; Endocrine Glands; Ensure; Exercise; Feedback; Goals; Health; Homeostasis; Human; Human Genetics; Hybrids; Immune; Immunologist; Injury; International; Knowledge; Learning; Life; Location; Maintenance; Mentors; Metabolic; Mitochondria; Molecular; Molecular Biology; Motor; Movement; Muscle; Muscle Cells; Muscle Development; Muscle Spindles; Muscle function; Muscle satellite cell; Muscular Dystrophies; Myasthenia; Myasthenia Gravis; Myoblasts; Myopathy; Nerve; Neurologic; Nuclear; Organ; Organ Size; Participant; Pathology; Physiology; Positioning Attribute; Proprioception; Request for Applications; Research; Research Personnel; Role; Scientist; Sensory; Series; Signal Transduction; Skeletal Muscle; Societies; Spinal muscular atrophy congenital; Stem cells; Tissues; Translational Research; Work; abstracting; age related; cell type; chromatin remodeling; design; frontier; insight; lectures; meetings; motor control; muscle aging; muscle degeneration; muscle form; muscle regeneration; myogenesis; nerve supply; normal aging; posters; public health relevance; relating to nervous system; response to injury; sarcopenia; success; symposium

 DESCRIPTION (provided by applicant): This application requests support for an international meeting, "Development and homeostasis of skeletal muscle in health and disease", which is part of the "Frontiers in Myogenesis" series sponsored by the Society for Muscle Biology. This conference series has been held triennially with great success for more than 20 years. This specific meeting will be held from June 6-11, 2016 at the Asilomar Conference Grounds in Pacific Grove, California. We expect approximately 300 participants from around the world. This conference is timely and significant for three reasons: First, although great strides have been made in understanding how muscle forms during early development, much remains to be learned about the mechanisms that govern muscle homeostasis, ensuring that muscle responds to injury and disease and adapts to functional demands during adult life and normal aging, when muscle mass and function is reduced. This meeting will focus upon new developments and directions in studying muscle homeostasis. Second, this meeting will cover several exciting new themes, three mentioned here, that have not been covered in depth during previous muscle conferences. There is an increasing appreciation that muscle can function as an endocrine organ and provide signals, myokines, which govern differentiation and function of multiple organs. This new awareness will be an important theme of this meeting; we have dedicated one session to this topic and expect participation from scientists who are new to the muscle field. Likewise, there is an increasing appreciation that immune cells have a critical role in muscle regeneration, and we have planned for a session that will include immunologists and recent converts to muscle biology. Finally, muscle spindles are critical for proprioception and represent a hybrid muscle cell type designed as a sensory and motor organ. The development of this critical muscle cell type requires sensory innervation, and we have planned for a session that will cover the mechanisms that govern their formation and maintenance and how muscle spindles control motor movement. Third, we plan for a session that will cover exciting new developments in studying myopathies and strategies for treating these diseases. As usual, we will include muscular dystrophy, but we also plan for talks on spinal muscular atrophy, congenital myasthenia and myasthenia gravis. This diversity of topics will not only serve to educate scientists about diseases with which they may be unfamiliar but also highlight cutting- edge new strategies for treating these diseases. The meeting will also cover important, traditional topics, including the biology of muscle satellite cells, mechanisms of muscle degeneration and regeneration, muscle specification and differentiation, myoblast fusion, and muscle cell architecture including nuclear and mitochondrial positioning.

 描述（由应用程序提供）：本申请要求支持国际会议，“健康与疾病中骨骼肌的发展和体内平衡”，这是由肌肉生物学协会赞助的“肌发生中的前沿”系列的一部分。该会议系列已经在三年中获得了巨大的成功，已有20多年的历史了。这次特定会议将于2016年6月6日至11日在加利福尼亚太平洋格罗夫的Asilomar会议场地举行。我们预计来自世界各地的大约300名参与者。这次会议是及时且重要的三个原因：首先，尽管在了解早期发育过程中的肌肉形成方面已经取得了长足的进步，但仍有许多待了解控制肌肉体内稳态的机制，确保肌肉对损伤和疾病的反应以及在减少肌肉质量和功能时适应成人生活和正常衰老过程中的功能需求。这次会议将重点介绍研究肌肉稳态的新发展和指示。其次，这次会议将涵盖几个令人兴奋的新主题，这里提到的三个主题在以前的肌肉会议期间没有深入涵盖。人们越来越多地认识到肌肉可以充当内分泌器官，并提供信号，肌动物，该信号控制多个器官的分化和功能。这种新的意识将是这次会议的重要主题。我们已经为这个主题献上了一个会议，并期望来自肌肉领域的科学家的参与。同样，越来越多的欣赏是免疫球在肌肉再生中具有关键作用，并且我们计划进行一次会议，其中包括免疫学家和最近转化为肌肉生物学。最后，肌肉纺锤体对于本体感受至关重要，代表一种杂种肌肉细胞类型，设计为一种感觉和运动器官。这种关键的肌肉细胞类型的发展需要感觉神经支配，我们计划进行一次会议，该会议将涵盖控制其形成和维护的机制，以及肌肉如何控制运动运动。第三，我们计划进行一次会议，该会议将涵盖研究肌病和治疗这些疾病策略的令人兴奋的新事态发展。像往常一样，我们将包括肌肉营养不良，但我们还计划就脊柱肌肉萎缩，先天肌无肌肌无力和肌无力进行肌无力进行谈判。这些主题的多样性不仅将有助于教育科学家有关他们可能不熟悉的疾病，而且还强调了治疗这些疾病的最先进的新策略。会议还将涵盖重要的传统主题，包括肌肉卫星细胞的生物学，肌肉变性和再生机制，肌肉规格和分化，成肌细胞融合以及包括核和线粒体定位在内的肌肉细胞结构。