Development and Homeostasis of Skeletal Muscle in Health and Disease

 描述（由申请人提供）：本申请请求支持一个国际会议，“健康和疾病中骨骼肌的发育和体内平衡”，这是肌肉生物学协会主办的“肌生成前沿”系列的一部分。该系列会议每三年举办一次，20多年来取得了巨大成功。本次会议将于2016年6月6日至11日在加州太平洋格罗夫的阿西洛马会议场地举行。我们预计将有来自世界各地的约300名与会者。 本次会议是及时和重要的三个原因：第一，虽然在了解肌肉如何形成在早期发展取得了很大的进步，仍有很多关于管理肌肉稳态的机制，以确保肌肉响应损伤和疾病，并适应功能需求在成年生活和正常老化，当肌肉质量和功能下降。这次会议将集中在研究肌肉稳态的新发展和方向。第二，本次会议将涵盖几个令人兴奋的新主题，这里提到的三个，在以前的肌肉会议上没有深入讨论。越来越多的人认识到，肌肉可以作为内分泌器官发挥作用，并提供信号，肌因子，其支配多个器官的分化和功能。这种新的认识将是本次会议的一个重要主题;我们专门为此主题举办了一次会议，并期待肌肉领域的新科学家的参与。同样，越来越多的人认识到免疫细胞在肌肉再生中起着关键作用，我们计划举办一次会议，其中包括免疫学家和最近皈依肌肉生物学的人。最后，肌梭对于本体感觉是至关重要的，并且代表了被设计为感觉和运动器官的混合肌细胞类型。这种关键的肌细胞类型的发展需要感觉神经支配，我们已经计划了一个会议，将涵盖管理其形成和维护的机制，以及肌梭如何控制运动。第三，我们计划一个会议，将涵盖令人兴奋的新发展，研究肌病和治疗这些疾病的策略。像往常一样，我们将包括肌肉萎缩症，但我们也计划对脊髓性肌萎缩症，先天性肌无力和重症肌无力会谈。这种主题的多样性不仅有助于教育科学家了解他们可能不熟悉的疾病，而且还突出了治疗这些疾病的尖端新策略。 会议还将涵盖重要的传统主题，包括肌肉卫星细胞的生物学，肌肉变性和再生的机制，肌肉规格和分化，成肌细胞融合和肌细胞结构，包括核和线粒体定位。

 DESCRIPTION (provided by applicant): This application requests support for an international meeting, "Development and homeostasis of skeletal muscle in health and disease", which is part of the "Frontiers in Myogenesis" series sponsored by the Society for Muscle Biology. This conference series has been held triennially with great success for more than 20 years. This specific meeting will be held from June 6-11, 2016 at the Asilomar Conference Grounds in Pacific Grove, California. We expect approximately 300 participants from around the world. This conference is timely and significant for three reasons: First, although great strides have been made in understanding how muscle forms during early development, much remains to be learned about the mechanisms that govern muscle homeostasis, ensuring that muscle responds to injury and disease and adapts to functional demands during adult life and normal aging, when muscle mass and function is reduced. This meeting will focus upon new developments and directions in studying muscle homeostasis. Second, this meeting will cover several exciting new themes, three mentioned here, that have not been covered in depth during previous muscle conferences. There is an increasing appreciation that muscle can function as an endocrine organ and provide signals, myokines, which govern differentiation and function of multiple organs. This new awareness will be an important theme of this meeting; we have dedicated one session to this topic and expect participation from scientists who are new to the muscle field. Likewise, there is an increasing appreciation that immune cells have a critical role in muscle regeneration, and we have planned for a session that will include immunologists and recent converts to muscle biology. Finally, muscle spindles are critical for proprioception and represent a hybrid muscle cell type designed as a sensory and motor organ. The development of this critical muscle cell type requires sensory innervation, and we have planned for a session that will cover the mechanisms that govern their formation and maintenance and how muscle spindles control motor movement. Third, we plan for a session that will cover exciting new developments in studying myopathies and strategies for treating these diseases. As usual, we will include muscular dystrophy, but we also plan for talks on spinal muscular atrophy, congenital myasthenia and myasthenia gravis. This diversity of topics will not only serve to educate scientists about diseases with which they may be unfamiliar but also highlight cutting- edge new strategies for treating these diseases. The meeting will also cover important, traditional topics, including the biology of muscle satellite cells, mechanisms of muscle degeneration and regeneration, muscle specification and differentiation, myoblast fusion, and muscle cell architecture including nuclear and mitochondrial positioning.