Development and Homeostasis of Skeletal Muscle in Health and Disease

 描述(申请人提供)：本申请请求支持一个名为“骨骼肌在健康和疾病中的发育和动态平衡”的国际会议，该会议是由肌肉生物学学会赞助的“肌肉发生的前沿”系列的一部分。这一系列会议每三年举行一次，20多年来取得了巨大成功。这一具体会议将于2016年6月6日至11日在加利福尼亚州太平洋格罗夫的阿西洛玛会议场地举行。我们预计将有来自世界各地的约300人参加。这次会议是及时和重要的，原因有三：首先，尽管在理解肌肉在早期发育过程中如何形成方面已经取得了很大的进步，但关于控制肌肉内稳的机制仍有许多需要了解，以确保肌肉对损伤和疾病做出反应，并适应成年生活和正常衰老期间的功能需求，当肌肉质量和功能减少时。本次会议将聚焦于肌肉动态平衡研究的新进展和方向。其次，这次会议将讨论几个令人兴奋的新主题，这里提到的三个，在以前的肌肉会议上没有深入讨论过。越来越多的人认识到，肌肉可以作为内分泌器官发挥作用，并提供控制多个器官分化和功能的信号--肌动蛋白。这种新的认识将是这次会议的一个重要主题；我们专门为这一主题举行了一次会议，并期待新进入肌肉领域的科学家参加。同样，越来越多的人认识到免疫细胞在肌肉再生中发挥着关键作用，我们已经计划了一次包括免疫学家和最近转向肌肉生物学的人参加的会议。最后，肌梭对本体感觉至关重要，代表了一种被设计为感觉和运动器官的杂交肌肉细胞类型。这种关键的肌肉细胞类型的发展需要感觉神经，我们已经计划了一次会议，将涵盖管理它们的形成和维持的机制，以及肌梭如何控制运动。第三，我们计划召开一次会议，讨论在研究肌病和治疗这些疾病的策略方面令人振奋的新进展。像往常一样，我们将包括肌营养不良，但我们也计划谈论脊髓性肌萎缩症、先天性肌无力和重症肌无力。这种多样化的主题不仅将有助于教育科学家了解他们可能不熟悉的疾病，而且还将突出治疗这些疾病的尖端新战略。会议还将讨论重要的传统主题，包括肌肉卫星细胞的生物学、肌肉退化和再生的机制、肌肉的规格和分化、成肌细胞融合以及包括核和线粒体定位在内的肌肉细胞结构。

 DESCRIPTION (provided by applicant): This application requests support for an international meeting, "Development and homeostasis of skeletal muscle in health and disease", which is part of the "Frontiers in Myogenesis" series sponsored by the Society for Muscle Biology. This conference series has been held triennially with great success for more than 20 years. This specific meeting will be held from June 6-11, 2016 at the Asilomar Conference Grounds in Pacific Grove, California. We expect approximately 300 participants from around the world. This conference is timely and significant for three reasons: First, although great strides have been made in understanding how muscle forms during early development, much remains to be learned about the mechanisms that govern muscle homeostasis, ensuring that muscle responds to injury and disease and adapts to functional demands during adult life and normal aging, when muscle mass and function is reduced. This meeting will focus upon new developments and directions in studying muscle homeostasis. Second, this meeting will cover several exciting new themes, three mentioned here, that have not been covered in depth during previous muscle conferences. There is an increasing appreciation that muscle can function as an endocrine organ and provide signals, myokines, which govern differentiation and function of multiple organs. This new awareness will be an important theme of this meeting; we have dedicated one session to this topic and expect participation from scientists who are new to the muscle field. Likewise, there is an increasing appreciation that immune cells have a critical role in muscle regeneration, and we have planned for a session that will include immunologists and recent converts to muscle biology. Finally, muscle spindles are critical for proprioception and represent a hybrid muscle cell type designed as a sensory and motor organ. The development of this critical muscle cell type requires sensory innervation, and we have planned for a session that will cover the mechanisms that govern their formation and maintenance and how muscle spindles control motor movement. Third, we plan for a session that will cover exciting new developments in studying myopathies and strategies for treating these diseases. As usual, we will include muscular dystrophy, but we also plan for talks on spinal muscular atrophy, congenital myasthenia and myasthenia gravis. This diversity of topics will not only serve to educate scientists about diseases with which they may be unfamiliar but also highlight cutting- edge new strategies for treating these diseases. The meeting will also cover important, traditional topics, including the biology of muscle satellite cells, mechanisms of muscle degeneration and regeneration, muscle specification and differentiation, myoblast fusion, and muscle cell architecture including nuclear and mitochondrial positioning.