Collaborative Research to Validate Biomarkers of Pediatric ARDS

 描述(由申请人提供)：NICHD儿科重症监护协作研究网络(CPCCRN，UG1)成立于2004年，旨在解决下列问题：(1)增加昂贵且复杂的儿科重症监护服务的利用率，(2)与成人和新生儿人口相比，缺乏儿科重症监护的预期临床试验本申请的主要目的是加入CPCCRN作为临床地点，以便通过在多个CPCCRN地点登记来扩大我们的单中心急性呼吸窘迫综合征(ARDS)儿童患者的前瞻性观察队列。ARDS是儿科危重疾病的常见原因(占PICU死亡人数的30%)。我们建议招募800名患有ARDS的儿童患者，并收集凝血和炎症的血浆和遗传生物标记物的临床数据。所获得的数据将是对前瞻性临床研究进行分层所必需的 并将提供对设计新疗法所需的基本分子和细胞疾病机制的洞察。加州大学旧金山分校医学中心和贝尼奥夫儿童医院、儿科急救医学部和儿科重症监护医学部长期参与开创性的多中心临床研究，以及由尖端个人研究员驱动的基础、转化和临床研究。这一传统，加上深厚的生物医学研究机构资源，使我们的中心处于理想的地位，可以向联盟提出新的建议，并全面参与网络赞助的研究。

 DESCRIPTION (provided by applicant): The NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN, UG1) was established in 2004 to address the following: (1) increased utilization of costly and complex pediatric critical care services and (2) lack of prospective clinical trials in pediatric critical care compared with adult and neonatal populations The primary Aim of this application is to join the CPCCRN as a clinical site, in order to expand our single center prospective observational cohort of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) through enrollment at multiple CPCCRN Sites. ARDS is a common cause of pediatric critical illness (30% of PICU mortalities). We propose to enroll 800 pediatric patients with ARDS and collect clinical data with plasma and genetic biomarkers of coagulation and inflammation. The data obtained will be essential for stratifying prospective clinical research trials and will provide insight into basic molecular and cellular disease mechanisms necessary for designing new treatments. UCSF Medical Center and Benioff Children's Hospital, the Department of Pediatrics and Division of Pediatric Critical Care Medicine have a long history of participation in ground breaking multicenter clinical research, as well as cutting edge individual investigator driven basic, translational and clinical research. This tradition, coupled with deep institutional resources for biomedical research, makes our center ideally positioned to contribute novel proposals to the consortium and participate fully in network-sponsored studies