Collaborative Research to Validate Biomarkers of Pediatric ARDS

 描述（由申请人提供）：NICHD协作儿科重症监护研究网络（CPCCRN，UG1）成立于2004年，旨在解决以下问题：（1）增加了对昂贵和复杂的儿科重症监护服务的利用，以及（2）与成人和新生儿人群相比，儿科重症监护缺乏前瞻性临床试验。本申请的主要目的是加入CPCCRN，作为临床研究中心，以便通过在多个CPCCRN研究中心入组，扩大我们的急性呼吸窘迫综合征（ARDS）儿科患者的单中心前瞻性观察队列。ARDS是儿科危重病的常见原因（占PICU死亡率的30%）。我们计划招募800例患有ARDS的儿科患者，并收集血浆和凝血和炎症的遗传生物标志物的临床数据。所获得的数据将是必要的分层前瞻性临床研究 试验，并将提供深入了解基本的分子和细胞疾病的机制，为设计新的治疗方法。加州大学旧金山分校医学中心和贝尼奥夫儿童医院，儿科系和儿科重症监护医学部在参与开创性的多中心临床研究以及尖端的个体研究者驱动的基础，转化和临床研究方面有着悠久的历史。这一传统，加上深厚的机构资源，生物医学研究，使我们的中心处于理想的位置，以贡献新的建议，以财团和充分参与网络赞助的研究

 DESCRIPTION (provided by applicant): The NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN, UG1) was established in 2004 to address the following: (1) increased utilization of costly and complex pediatric critical care services and (2) lack of prospective clinical trials in pediatric critical care compared with adult and neonatal populations The primary Aim of this application is to join the CPCCRN as a clinical site, in order to expand our single center prospective observational cohort of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) through enrollment at multiple CPCCRN Sites. ARDS is a common cause of pediatric critical illness (30% of PICU mortalities). We propose to enroll 800 pediatric patients with ARDS and collect clinical data with plasma and genetic biomarkers of coagulation and inflammation. The data obtained will be essential for stratifying prospective clinical research trials and will provide insight into basic molecular and cellular disease mechanisms necessary for designing new treatments. UCSF Medical Center and Benioff Children's Hospital, the Department of Pediatrics and Division of Pediatric Critical Care Medicine have a long history of participation in ground breaking multicenter clinical research, as well as cutting edge individual investigator driven basic, translational and clinical research. This tradition, coupled with deep institutional resources for biomedical research, makes our center ideally positioned to contribute novel proposals to the consortium and participate fully in network-sponsored studies