Translational Epidemiology - Training for Research on Aging and Chronic disease

 描述（由申请人提供）：慢性病是对个人和卫生保健系统的一个重大全球挑战。将慢性病流行病学转化为实践和政策所需的知识和技能正在迅速变化。下一代研究人员必须具备以下能力：在人口背景下利用执行科学的发展;利用新的数据来源和联系;利用计算工具的迅速进步;利用统计方法的创新，重点是翻译和执行。该培训计划将通过提供适用于多种研究相关职业途径的培训来解决NIH生物医学研究和劳动力工作组的问题。该方案（转化流行病学-老龄化和慢性病研究培训：TE-TRAC）侧重于老年慢性病，包括阿尔茨海默病和相关疾病、癌症、肌肉骨骼和心脏代谢疾病。我们计划的四个独特优势是：1）人口和实施科学研究的整合; 2）使用实施科学的教学和体验培训，以预防和延迟与主要衰老相关的慢性疾病的发病率和进展; 3）强调在复杂数据集中进行纵向研究的严格方法; 4）使用多层次的数据链接，包括基因组学、从电子病历中提取的临床信息以及环境或社会概况。我们计划的实施科学和翻译部分在专注于慢性病流行病学的培训计划中是独一无二的。正式的培训将与临床实践，卫生政策和健康实践的经验轮换相结合。该计划将包括纳入课程，双周跨学科研讨会，并由著名的慢性病研究人员指导的关键活动。该计划强调与研究设计，分析和翻译相关的知识和技能的发展，为学员提供在慢性病流行病学新时代作为独立研究人员脱颖而出的工具。教师导师反映了UCSF社区在临床和人口研究领域的深度和广度。该计划将由流行病学和生物统计学系领导。我们将培养博士前和博士后学员。在五年内，我们将培养总共16名科学家。我们的计划将培养新一代的 慢性病流行病学家，有能力利用新兴的工具/资源，开发高效的方法来促进健康老龄化。学员将在学术界，政策，通信，私营企业和健康研究部门担任领导职务。

 DESCRIPTION (provided by applicant): Chronic disease represents a major global challenge to individuals and the health care system. The knowledge and skills necessary for translation of chronic disease epidemiology into practice and policy are rapidly changing. The next generation of researchers must be equipped to capitalize on the development of implementation science in a population context, on new data sources and linkages; rapid advances in computational tools; and innovations in statistical methods, with an emphasis on translation and implementation. This training program will address the concerns of the NIH Biomedical Research and Workforce working Group by providing training applicable to multiple research related career pathways. The program (Translational Epidemiology - Training for Research on Aging and Chronic disease: TE-TRAC) focuses on chronic diseases of aging, including Alzheimer's disease and related disorders, cancer, musculoskeletal, and cardiometabolic disorders. Four unique strengths of our program are: 1) integration of population and implementation science research; 2) didactic and experiential training using implementation science to prevent and delay incidence and progression of major aging related chronic conditions; 3) emphasis on rigorous methods for longitudinal research in complex data sets; 4) use of multi-level data linkages, including genomics, clinical information drawn from electronic medical records, and environmental or social profiles. The implementation science and translational component of our program is unique among training programs that focus on chronic disease epidemiology. Formal training will be combined with experiential rotations in clinical practice, health policy, and publc health practice. The program will include key activities incorporating coursework, biweekly interdisciplinary seminars, and mentoring by renowned chronic disease researchers. The program emphasizes development of knowledge and skills related to research design, analysis, and translation, providing trainees the tools to excel as independent researchers in a new era of chronic disease epidemiology. Faculty mentors reflect the depth and breadth of the UCSF community in both clinical and population research domains. This program will be led by the department of Epidemiology and Biostatistics. We will train both pre- and post-doctoral trainees. Over five years, we will train a total of 16 scientists. Our program will train a new generation of chronic disease epidemiologists, equipped to take advantage of emerging tools/resources to develop highly effective approaches to promote healthy aging. Trainees will take leadership positions in academia, policy, communications, private industry and the health research sector.