Translational Epidemiology - Training for Research on Aging and Chronic disease

 描述(由申请者提供)：慢性病是对个人和医疗保健系统的一项重大全球挑战。将慢性病流行病学转化为实践和政策所需的知识和技能正在迅速变化。下一代研究人员必须具备能力，以便在人口背景下利用执行科学的发展，利用新的数据来源和联系；计算工具的快速进步；以及统计方法的创新，重点是翻译和实施。该培训计划将通过提供适用于多个研究相关职业道路的培训来解决NIH生物医学研究和劳动力工作组的担忧。该计划(翻译流行病学-老龄化和慢性病研究培训：TE-TRAC)专注于老年性慢性疾病，包括阿尔茨海默病及其相关疾病、癌症、肌肉骨骼和心脏新陈代谢疾病。我们计划的四个独特优势是：1)人口和实施科学研究的整合；2)使用实施科学进行授课和体验式培训，以预防和延缓与老龄化相关的主要慢性病的发生和进展；3)强调复杂数据集的纵向研究的严格方法；4)使用多层次数据链接，包括基因组学、从电子医疗记录中提取的临床信息以及环境或社会概况。我们计划的实施科学和翻译部分在专注于慢性病流行病学的培训计划中是独一无二的。正规培训将与临床实践、卫生政策和公共卫生实践的经验轮换相结合。该计划将包括关键活动，包括课程作业，两周一次的跨学科研讨会，以及知名慢性病研究人员的指导。该项目强调与研究设计、分析和翻译相关的知识和技能的发展，为学员提供在慢性病流行病学的新时代作为独立研究人员脱颖而出的工具。教师导师反映了加州大学旧金山分校社区在临床和人口研究领域的深度和广度。这项计划将由流行病学和生物统计学系领导。我们将对博士后和博士后实习生进行培训。在五年内，我们将总共培养16名科学家。我们的计划将培养新一代 慢性病流行病学家，有能力利用新出现的工具/资源来开发高效的方法来促进健康老龄化。学员将在学术界、政策、通信、私营行业和卫生研究部门担任领导职务。

 DESCRIPTION (provided by applicant): Chronic disease represents a major global challenge to individuals and the health care system. The knowledge and skills necessary for translation of chronic disease epidemiology into practice and policy are rapidly changing. The next generation of researchers must be equipped to capitalize on the development of implementation science in a population context, on new data sources and linkages; rapid advances in computational tools; and innovations in statistical methods, with an emphasis on translation and implementation. This training program will address the concerns of the NIH Biomedical Research and Workforce working Group by providing training applicable to multiple research related career pathways. The program (Translational Epidemiology - Training for Research on Aging and Chronic disease: TE-TRAC) focuses on chronic diseases of aging, including Alzheimer's disease and related disorders, cancer, musculoskeletal, and cardiometabolic disorders. Four unique strengths of our program are: 1) integration of population and implementation science research; 2) didactic and experiential training using implementation science to prevent and delay incidence and progression of major aging related chronic conditions; 3) emphasis on rigorous methods for longitudinal research in complex data sets; 4) use of multi-level data linkages, including genomics, clinical information drawn from electronic medical records, and environmental or social profiles. The implementation science and translational component of our program is unique among training programs that focus on chronic disease epidemiology. Formal training will be combined with experiential rotations in clinical practice, health policy, and publc health practice. The program will include key activities incorporating coursework, biweekly interdisciplinary seminars, and mentoring by renowned chronic disease researchers. The program emphasizes development of knowledge and skills related to research design, analysis, and translation, providing trainees the tools to excel as independent researchers in a new era of chronic disease epidemiology. Faculty mentors reflect the depth and breadth of the UCSF community in both clinical and population research domains. This program will be led by the department of Epidemiology and Biostatistics. We will train both pre- and post-doctoral trainees. Over five years, we will train a total of 16 scientists. Our program will train a new generation of chronic disease epidemiologists, equipped to take advantage of emerging tools/resources to develop highly effective approaches to promote healthy aging. Trainees will take leadership positions in academia, policy, communications, private industry and the health research sector.