Life course epidemiology of women's reproductive health and its relation to chronic disease

女性生殖健康生命历程流行病学及其与慢性病的关系

• 批准号: MR/M009351/1
• 负责人: Abigail Fraser
• 金额: $ 107.44万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM009351%2F1
• 关键词: Life; course; epidemiology; women; reproductive

Reproductive health is important to a woman's overall health and well-being and is increasingly recognised as a marker for other diseases that she might experience later on in life. However there are gaps in our knowledge about what causes some women to have poorer reproductive health, for example, have highly irregular menstrual cycles, difficulties getting pregnant, or experience hot flashes and night sweats around menopause. I propose to answer these gaps. I will use information from several large studies that include many women, some of which have collected information on women since they were in the womb or since their birth. I will use this information to find out what affects their reproductive hormone levels, their menstrual patterns and how easy it is for them to get pregnant in early adulthood, and how likely they are to have complications of pregnancy. This is important as some of the causes of poor reproductive health may be preventable. Also, women are increasingly having children at older ages and it is important that we understand what affects women's chances of getting pregnant and having a healthy pregnancy. There are also gaps in our understanding of why women with poorer reproductive health, including complications of pregnancy, such as pre-eclampsia, are more likely to have other diseases later in their life such as heart disease. Here too I will use large studies of older women, to find out why some women with poorer reproductive health are more likely to have heart disease, diabetes, breast cancer and other diseases later in life. Understanding the relationship between women's reproductive health and other diseases is important as it may identify potential new treatments. I will also assess whether information about reproductive health which women accurately and easily remember can be used to accurately predict their chances of having diabetes, heart and bone disease and dementia later in life. This is important as women at high risk can then be offered advice or treatment that will lower that risk.

生殖健康对妇女的整体健康和福祉很重要，人们越来越认识到，生殖健康是妇女今后可能患上其他疾病的标志。然而，我们对导致一些妇女生殖健康状况较差的原因的认识存在差距，例如，月经周期非常不规则，怀孕困难，或更年期前后出现潮热和盗汗。我建议填补这些空白。我将使用几项大型研究的信息，这些研究包括许多女性，其中一些收集了女性在子宫内或出生后的信息。我将利用这些信息来了解是什么影响了她们的生殖激素水平，她们的月经模式，以及她们在成年早期怀孕的容易程度，以及她们患妊娠并发症的可能性。这一点很重要，因为造成生殖健康不良的一些原因是可以预防的。此外，越来越多的妇女在年龄较大的时候生孩子，我们必须了解是什么影响了妇女怀孕和健康怀孕的机会。我们对为什么生殖健康较差的妇女，包括妊娠并发症，如先兆子痫，更有可能在以后的生活中患上其他疾病，如心脏病的理解也存在差距。在这里，我也将使用对老年妇女的大型研究，以找出为什么一些生殖健康较差的妇女更容易患心脏病，糖尿病，乳腺癌和其他疾病。了解妇女生殖健康与其他疾病之间的关系很重要，因为它可能会发现潜在的新治疗方法。我还将评估妇女准确和容易记住的生殖健康信息是否可以用来准确预测她们以后患糖尿病、心脏病和骨病以及痴呆症的几率。这一点很重要，因为高风险的妇女可以得到降低风险的建议或治疗。

项目成果

Additional file 1: of Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development

附加文件 1：童年期心理社会逆境与成年期心血管疾病危险因素的前瞻性关联：MRC 国家健康与发展调查

• DOI: 10.6084/m9.figshare.c.3874363_d1
• 发表时间: 2017
• 作者: Anderson E

Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents.

• DOI: 10.3945/jn.114.208397
• 发表时间: 2015-05
• 期刊: The Journal of nutrition
• 作者: Anderson EL;Howe LD;Fraser A;Macdonald-Wallis C;Callaway MP;Sattar N;Day C;Tilling K;Lawlor DA
• 通讯作者: Lawlor DA

Being Silenced, Loneliness and Being Heard: understanding pathways to Intimate Partner Violence & Abuse in young adults. A mixed-methods study

沉默、孤独和被倾听：了解亲密伴侣暴力的途径

• DOI: 10.21203/rs.3.rs-1542724/v1
• 发表时间: 2022
• 作者: Barnes M

The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis.

• DOI: 10.1371/journal.pone.0140908
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Anderson EL;Howe LD;Jones HE;Higgins JP;Lawlor DA;Fraser A
• 通讯作者: Fraser A

Additional file 1 of Being silenced, loneliness and being heard: understanding pathways to intimate partner violence & abuse in young adults. a mixed-methods study

附加文件 1：沉默、孤独和被倾听：了解亲密伴侣暴力的途径

• DOI: 10.6084/m9.figshare.20501903
• 发表时间: 2022
• 作者: Barnes M