Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心，核心III，将通过为加州大学洛杉矶分校的研究人员及其同事提供最先进的生物统计学，生物信息学，数据管理和临床试验支持，促进前列腺癌的转化研究。该核心为UCLA的前列腺癌研究人员及其合作者提供了一个集中的生物统计学/生物信息学支持和数据管理网络。核心的总体目标是为SPORE的基础和临床研究者提供统计和数据管理支持。这包括为临床前和临床研究计划提供把握度分析，以及在出版前对所有已完成研究进行统计分析。Core还为所有基因组学研究提供分析服务，包括SPORE内的测序和基因表达阵列。除了这些统计服务，核心在加州大学洛杉矶分校前列腺癌孢子临床数据库的管理中发挥着核心作用。核心设计和管理基于网络的前列腺孢子临床数据库。对数据库进行了不断改进，以便利数据输入和工作流程，并为统计和其他查询提供一个无缝的环境。该数据库与生物标本库以及病理学核心管理的组织阵列相连接。 核心的目的是提供全面的统计咨询和分析，以个别项目的SPORE调查。这还将包括使用统计软件的教育、手稿的编写以及新的赠款申请的编写和提交。它旨在提供设施和计算领导力，以使用组织阵列、微阵列基因表达、流式细胞术等高维技术设计和实施项目。还将提供软件和最新的统计方法。其目的是维护和开发一个中央数据库，并为所有孢子项目和核心提供数据管理/质量控制活动。这一职能将包括开发和应用其他数据管理和统计方案编制工具。

The Biostatistics and Bioinformatics Core, Core III, will facilitate translational research in prostate cancer, by providing UCLA investigators and their colleagues with state of the art biostatistical, bioinformatics, data management and clinical trials support. The core provides a centralized network of biostatistics/bioinformatics support and data management for prostate cancer researchers at UCLA and their collaborators. The overall goal of the Core is to provide statistical and data management support to basic and clinical investigators in the SPORE. This includes provision of power analyses for planning of preclinical and clinical studies and statistical analysis of all completed studies prior to publication. The Core also provides analytical services for all genomics research, including sequencing and gene expression arrays within the SPORE. In addition to these statistical services, the Core plays a central role in the management of the UCLA Prostate Cancer SPORE clinical database. The Core had designed and manages the web-based Prostate SPORE clinical database. Continual improvements to the database have been made to facilitate data input and workflow, as well as to provide a seamless environment for statistical and other inquiries. The database is linked to the biospecimen repository, as well as to the tissue arrays managed by the Pathology Core. The Core aims to provide comprehensive statistical consultation and analysis to the individual projects to SPORE investigators. This will also include education in the use of statistical software, preparation of manuscripts, and development and submission of new grant applications. It aims to provide a facility and computational leadership to design and carry out projects using high-dimensional technologies including tissue array, microarray gene expression, flow cytometry. Software and up-to-date statistical methodology will also be provided. It aims to maintain and develop a central data repository and provide data management/quality control activities for all SPORE projects and cores. This function will include development and application of additional data management and statistical programming tools.