Training in Environmental Pathology

描述(由申请人提供) 这个博士后和博士后培训项目的目标是教育新一代环境病理学家使用细胞生物学、生物化学、分子生物学和系统生物学的工具来研究与环境暴露有关的疾病的基本机制。中心重点是一个独立的实验室研究项目，旨在探索因接触工业废物和环境污染物(包括金属、塑化剂、杀虫剂、微粒、纳米材料和多环芳烃)而导致的生殖功能改变、不良发育和妊娠结局、代谢综合征和癌症的发病机制。要求为参加布朗大学病理生物学研究生计划的6名博士后实习生和3名博士后实习生提供最长三年的支持。博士前实习生将招聘生物、化学、毒理学或环境科学专业，并致力于疾病机制和环境健康的基础研究。博士后实习生可以拥有基础科学学科、病理学或毒理学的博士学位。所有受训人员都被要求学习人类疾病的基本机制和形态表现。还提供了分子病理学、成像、环境毒理学、信号转导、癌症发生和生物统计学方面的培训。所有受训人员将接受负责任的研究指导，并将有机会 在布朗大学谢里登教学中心培养他们的沟通和教学技能。授课课程的补充是每周的研究研讨会、学生期刊俱乐部、职业发展和资历研讨会，以及年度静修。为罗德岛医院和妇幼医院的临床和转化性研究合作提供机会，以及在罗德岛现有的工业废弃场和棕地进行实地工作和社区推广。这14名教师有积极的、资金充足的研究项目，由27项积极的研究资助、3项培训资助、2项科布雷资助、一项NIEHS P42超级基金研究资助、一项P20形成中心资助，以及国家儿童研究中心的一项试点项目。受训人员可以使用配备有定量成像、激光捕获显微解剖、基因组学和蛋白质组学、流式细胞术、转基因动物以及人类组织和样本库的现代研究设施。这些学员将与流行病学、毒理学、公共卫生和政府监管机构的专家合作，准备将他们的基础研究专业知识应用于复杂环境健康问题的定义、分析和解决方案。

DESCRIPTION (provided by applicant) The objective of this pre-doctoral and postdoctoral Training Program is to educate a new generation of environmental pathologists to use the tools of cell biology, biochemistry, molecular biology, and systems biology to study basic mechanisms of disease related to environmental exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive function, adverse developmental and pregnancy outcomes, the metabolic syndrome, and cancer resulting from exposure to industrial wastes and environmental contaminants including metals, plasticizers, pesticides, particulates, nanomaterials, and PAHs. Support is requested for 6 pre-doctoral trainees enrolled in the Pathobiology Graduate Program at Brown University and for 3 postdoctoral trainees for up to three years. Pre-doctoral trainees will be recruited with majors in biology, chemistry, toxicology or environmental sciences and a commitment to basic research on mechanisms of disease and environmental health. Postdoctoral trainees may hold doctoral degrees in a basic science discipline, pathology, or toxicology. All trainees are required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also provided in molecular pathology, imaging, environmental toxicology, signal transduction, carcinogenesis, and biostatistics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development and grantsmanship workshops, and annual retreats. Opportunities are provided for clinical and translational research collaborations at Rhode Island Hospital and Women & Infants' Hospital, as well as field work and community outreach at existing industrial waste sites and Brownfields in Rhode Island. The 14 faculty have active, well-funded research programs supported by 27 active research grants, 3 training grants, 2 COBRE grants, an NIEHS P42 Superfund Research Grant, a P20 Formative Center Grant, and a pilot project from the National Children's Study. Trainees have access to modern research facilities equipped for quantitative imaging, laser capture microdissection, genomics and proteomics, flow cytometry, transgenic animals, and human tissue and specimen banks. These trainees will be prepared to apply their basic research expertise to the definition, analysis, and solution of complex environmental health problems working together with experts in epidemiology, toxicology, public health, and government regulatory agencies.