Training in Environmental Pathology

描述（由申请人提供） 该博士前和博士后培训计划的目标是教育新一代环境病理学家使用细胞生物学，生物化学，分子生物学和系统生物学的工具来研究与环境暴露相关的疾病的基本机制。中心重点是一个独立的实验室研究项目，探索改变生殖功能，不良发育和妊娠结局，代谢综合征和癌症的发病机制，这些疾病是由于暴露于工业废物和环境污染物（包括金属，增塑剂，农药，颗粒物，纳米材料和多环芳烃）而导致的。 要求为布朗大学病理生物学研究生方案招收的6名博士前受训人员和3名博士后受训人员提供最长三年的支助。 博士前培训生将被招募与生物学，化学，毒理学或环境科学专业，并致力于疾病和环境健康机制的基础研究。博士后学员可以持有基础科学学科、病理学或毒理学的博士学位。 所有学员都必须学习人类疾病的基本机制和形态表现。还提供分子病理学、成像、环境毒理学、信号转导、致癌作用和生物统计学方面的培训。 所有受训人员将接受负责任的研究指导，并有机会 在布朗大学的谢里丹教学中心发展他们的沟通和教学技能。 教学课程由每周的研究研讨会，学生期刊俱乐部，职业发展和granitarian研讨会，以及年度务虚会补充。 为罗得岛医院和妇女与婴儿医院的临床和转化研究合作提供了机会，以及在罗得岛现有工业废物场地和棕地的实地工作和社区外展。14个教师有积极的，资金充足的研究项目，由27个积极的研究赠款，3个培训赠款，2个COBRE赠款，一个NIEHS P42超级基金研究补助金，一个P20形成中心补助金和一个试点项目从国家儿童研究支持。学员可以使用现代化的研究设施，这些设施配备有定量成像、激光捕获显微切割、基因组学和蛋白质组学、流式细胞术、转基因动物以及人体组织和标本库。这些学员将准备应用他们的基础研究专业知识，以定义，分析和复杂的环境健康问题的解决方案与流行病学，毒理学，公共卫生和政府监管机构的专家一起工作。

DESCRIPTION (provided by applicant) The objective of this pre-doctoral and postdoctoral Training Program is to educate a new generation of environmental pathologists to use the tools of cell biology, biochemistry, molecular biology, and systems biology to study basic mechanisms of disease related to environmental exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive function, adverse developmental and pregnancy outcomes, the metabolic syndrome, and cancer resulting from exposure to industrial wastes and environmental contaminants including metals, plasticizers, pesticides, particulates, nanomaterials, and PAHs. Support is requested for 6 pre-doctoral trainees enrolled in the Pathobiology Graduate Program at Brown University and for 3 postdoctoral trainees for up to three years. Pre-doctoral trainees will be recruited with majors in biology, chemistry, toxicology or environmental sciences and a commitment to basic research on mechanisms of disease and environmental health. Postdoctoral trainees may hold doctoral degrees in a basic science discipline, pathology, or toxicology. All trainees are required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also provided in molecular pathology, imaging, environmental toxicology, signal transduction, carcinogenesis, and biostatistics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development and grantsmanship workshops, and annual retreats. Opportunities are provided for clinical and translational research collaborations at Rhode Island Hospital and Women & Infants' Hospital, as well as field work and community outreach at existing industrial waste sites and Brownfields in Rhode Island. The 14 faculty have active, well-funded research programs supported by 27 active research grants, 3 training grants, 2 COBRE grants, an NIEHS P42 Superfund Research Grant, a P20 Formative Center Grant, and a pilot project from the National Children's Study. Trainees have access to modern research facilities equipped for quantitative imaging, laser capture microdissection, genomics and proteomics, flow cytometry, transgenic animals, and human tissue and specimen banks. These trainees will be prepared to apply their basic research expertise to the definition, analysis, and solution of complex environmental health problems working together with experts in epidemiology, toxicology, public health, and government regulatory agencies.