Quantitative Blood Flow Imaging using Spin Labeled MR Fingerprinting
Quantitative Blood Flow Imaging using Spin Labeled MR Fingerprinting
批准号:
9016765
负责人:
Luis Hernandez-Garcia
金额:
$21.29万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-03-01 至 2017-12-31
关键词:
AdoptedAgreementAlzheimer&aposs DiseaseBiological MarkersBloodBlood VesselsBlood VolumeBlood flowBolus InfusionBrainCerebrovascular CirculationClinicClinicalClinical ResearchCommunitiesComputer softwareContrast MediaDataDevelopmentDiagnosisDictionaryDiseaseEarly DiagnosisEquationFaceFingerprintFrequenciesGadoliniumGenetic ProgrammingHealthHuman VolunteersImageImaging TechniquesInjection of therapeutic agentLabelLinkMagnetic ResonanceMagnetic Resonance ImagingMalignant NeoplasmsMapsMeasurementMeasuresMental disordersMetabolicMethodsMorphologic artifactsMultiple SclerosisNoiseOrganPerfusionPhysiciansPhysiologic pulsePopulationPositron-Emission TomographyPrevalenceProcessProtocols documentationRadioactiveRegulationReproducibilityResearch PersonnelResolutionRiskScanningSchemeScientistSignal TransductionSiteSpeedSpin LabelsStagingStrokeTechniquesTimeTissuesToxic effectTracerTranslatingTreatment EfficacyValidationWaterWhite Matter Diseasebasebrain tissuecerebral hemodynamicscognitive functiongadolinium oxidehemodynamicsnon-invasive imagingpublic health relevancequantitative imagingradiofrequencysuccesstoolvalidation studieswhite matter
中文摘要
英文摘要
DESCRIPTION (provided by applicant): There is a clear need for a robust method to image cerebral hemodynamics to better understand disease processes, as well as to develop early stage disease biomarkers. Many diseases like cancer and stroke are characterized by deficits in perfusion and changes in other blood flow related parameters. There is also mounting evidence suggesting that poor regulation of cerebral blood flow is closely linked to the development of several diseases whose prevalence is on the rise, like multiple sclerosis and Alzheimer's disease. While routine clinical perfusion imaging is cumbersome and requires the injection of contrast agents. Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique to image perfusion without injection of contrast agents. ASL is rapidly gaining prominence in the clinic because perfusion can yield crucial information about the health of brain tissue and its vasculature, although it is being used with increasing frequency in other organs as well. While ASL's potential as a clinical and research tool is phenomenal, the technique is still severely challenged by low signal to noise ratio (SNR). These challenges are exacerbated in the white matter because of its low perfusion rate and longer transit time from the labeling site to the voxel. In this proposal we aim to develop a new acquisition and quantification framework for imaging perfusion and other physiologically relevant parameters. This framework takes advantage of newly developed MR fingerprinting techniques. We aim to optimize this framework in order to maximize the sensitivity and accuracy, while reducing the scan time. Finally, we aim to validate the technique by comparison to independent measurements of the same parameters using alternative, established methods.
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会议论文
Development of Layer Specific FMRI for Clinical Scanners
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批准号:10589648
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项目类别:
-
资助金额:$39.06万
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财政年份:2023
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负责人:Luis Hernandez-Garcia
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依托单位:
Quantitative MR Imaging of Vascular Factors in Parkinsons Disease
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批准号:10650733
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项目类别:
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资助金额:$41.51万
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财政年份:2020
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负责人:Luis Hernandez-Garcia
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依托单位:
Quantitative MR Imaging of Vascular Factors in Parkinsons Disease
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批准号:10438882
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项目类别:
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资助金额:$39.5万
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财政年份:2020
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负责人:Luis Hernandez-Garcia
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依托单位:
Quantitative MR Imaging of Vascular Factors in Parkinsons Disease
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批准号:10266020
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项目类别:
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资助金额:$28.1万
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财政年份:2020
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负责人:Luis Hernandez-Garcia
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依托单位:
Dosimetry and improved targeting for Transcranial Magnetic Stimulation
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批准号:7514543
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项目类别:
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资助金额:$19.72万
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财政年份:2008
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负责人:Luis Hernandez-Garcia
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依托单位:
Fast, Quantitative, Perfusion-Based functional-MRI
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批准号:7085519
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项目类别:
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资助金额:$19.29万
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财政年份:2005
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负责人:Luis Hernandez-Garcia
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依托单位:
Fast, Quantitative, Perfusion-Based functional-MRI
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批准号:7225603
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项目类别:
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资助金额:$18.69万
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财政年份:2005
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负责人:Luis Hernandez-Garcia
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依托单位:
Fast, Quantitative, Perfusion-Based functional-MRI
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批准号:6965781
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项目类别:
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资助金额:$19.88万
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财政年份:2005
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负责人:Luis Hernandez-Garcia
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依托单位:
海外基金