Evaluation of cardiotoxicity and neurotoxicity combined with hepatotoxicity of 32 compounds in zebrafish embryos
Evaluation of cardiotoxicity and neurotoxicity combined with hepatotoxicity of 32 compounds in zebrafish embryos
批准号:
9367503
负责人:
ARANTZA MURIANA
金额:
$12.5万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-10-16 至 2016-10-15
中文摘要
将在斑马鱼胚胎中采用一系列试验评价32种化学品(18种发育毒物、7种神经毒物、5种未知物质和3种阴性对照)。 将采用5种浓度/化合物(0.1-1000 μM)测定最大耐受浓度。 神经毒性、行为改变(即,神经毒性)和肝毒性(n=10-20)。
英文摘要
32 chemicals (18 developmental toxicants, 7 neurotoxicants, 5 unknowns, and 3 negative controls) will be evaluated with a battery of assays in zebrafish embryos. The maximum tolerated concentration will be determined with 5 concentrations/compound (0.1-1000 μM). Cardiotoxicity, behavioral alteration (i.e., neurotoxicity), and hepatotoxicity (n=10-20) following compound exposure will be evaluated conducted in zebrafish embryos.
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会议论文
Developmental Neurotoxicity Zebrafish Bioavailability Assay - task order 3
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批准号:10475424
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项目类别:
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资助金额:$16.39万
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财政年份:2021
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负责人:ARANTZA MURIANA
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依托单位:--
Developmental Neurotoxicity Zebrafish Assay and Data Collection - task order 1
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批准号:10475421
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项目类别:
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资助金额:$16.94万
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财政年份:2021
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负责人:ARANTZA MURIANA
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依托单位:--
Developmental Neurotoxicity Zebrafish Assay and Data Analysis and Reporting - task order 2
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批准号:10475423
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项目类别:
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资助金额:$6.92万
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财政年份:2021
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负责人:ARANTZA MURIANA
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依托单位:--
海外基金