Evaluation of cardiotoxicity and neurotoxicity combined with hepatotoxicity of 32 compounds in zebrafish embryos

32种化合物对斑马鱼胚胎的心脏毒性、神经毒性及肝毒性评价

• 批准号: 9367503
• 负责人: ARANTZA MURIANA
• 金额: $ 12.5万
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-10-16 至 2016-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9367503
• 关键词: Behavioral; Biological; Biological Assay; Cardiotoxicity; Chemicals; Development; Embryo; Evaluation; Hepatotoxicity; Neurotoxins; System; Toxic effect; Work; Zebrafish; in vitro Model; neurotoxicity; toxicant

32 chemicals (18 developmental toxicants, 7 neurotoxicants, 5 unknowns, and 3 negative controls) will be evaluated with a battery of assays in zebrafish embryos. The maximum tolerated concentration will be determined with 5 concentrations/compound (0.1-1000 μM). Cardiotoxicity, behavioral alteration (i.e., neurotoxicity), and hepatotoxicity (n=10-20) following compound exposure will be evaluated conducted in zebrafish embryos.

32种化学物质（18种发育毒性物质，7种神经毒性物质，5种未知物质和3种阴性对照）将在斑马鱼胚胎中进行一系列测定。最大耐受浓度为5个浓度/化合物（0.1 ~ 1000 μM）。将在斑马鱼胚胎中评估化合物暴露后的心脏毒性、行为改变（即神经毒性）和肝毒性（n=10-20）。