UT-Houston Regional Stroke Center

描述（由申请人提供）：25年来，我们的中心一直是中风和脑出血新疗法临床试验的领导者。在这项申请中，我们的目标是成为NINDS临床试验中风网络中领先的区域中风协调中心，并组建了一个组织良好的临床研究中心，这些临床研究中心通过富有成效的合作历史联系在一起，并由多学科和种族多元化的团队领导。在具体目标1中，我们打算领导一个由多学科团队组成的区域卒中协调中心（RCC），以进行临床试验，测试急性卒中、卒中预防和卒中恢复方面的新型卒中疗法。UT休斯顿RCC将在大休斯顿地区、圣安东尼奥和新奥尔良的互联网站网络内进行临床试验，涉及成人和儿童患者，并注意招募少数民族和妇女。在具体目标2中，我们将为新型试验的设计提供专业知识和领导力，并提出在急性卒中、卒中预防和卒中恢复中测试新型卒中疗法的试验。我们还将提供从实验室到床边的新中风疗法的开发以及新生物标志物的开发和测试的翻译专业知识。在具体的目标3中，我们将在我们的网络中为临床医生-科学家建立一个培训计划，这些科学家在中风的独立研究事业中具有很高的潜力。

DESCRIPTION (provided by applicant): Our center for 25 years has been a leader in clinical trials testing new treatments for stroke and brain hemorrhage. In this application, we aim to serve as a leading regional stroke coordinating center in the NINDS clinical trials stroke network and have assembled a well-organized group of connected clinical sites linked by a history of productive collaboration and led by a multidisciplinary and ethnically diverse team. In Specific Aim 1, we intend to lead a regional stroke coordinating center (RCC) consisting of multidisciplinary teams to conduct clinical trials testing novel stroke therapies in acute stroke, stroke prevention, and stroke recovery. The UT-Houston RCC will conduct clinical trials within a network of inter-connected sites in the greater Houston area, San Antonio, and New Orleans involving both adult and pediatric patients with attention to the recruitment of minorities and women. In specific Aim 2, we will provide expertise and leadership for the design of novel trials and propose trials testing new stroke therapies in acute stroke, stroke prevention, and stroke recovery. We will also provide translational expertise for the development of new stroke therapies from bench to bedside and for the development and testing of novel biomarkers. In specific Aim 3, we will establish a training program within our network for clinician-scientists wih high potential for independent research careers in stroke.