Gulf Regional Area Stroke Program and Oklahoma

海湾地区中风计划和俄克拉荷马州

• 批准号: 10268032
• 负责人: Sean I Savitz
• 金额: $ 19.97万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10268032
• 关键词: Adult; Alabama; Anticoagulants; Area; Arteries; Attention; Brain hemorrhage; Caring; Cerebral hemisphere hemorrhage; Clinical Research; Clinical Trials; Coagulation Process; Collaborations; Communities; Conduct Clinical Trials; Development; Devices; Education; Enrollment; Environment; Lead; Leadership; Link; Louisiana; Minority; Minority Recruitment; Mississippi; National Institute of Neurological Disorders and Stroke; Oklahoma; Oral; Patients; Phase; Philosophy; Randomized Clinical Trials; Recording of previous events; Recovery; Rehabilitation therapy; Reperfusion Therapy; Research; Retrieval; Scientist; Site; Stroke; Stroke prevention; Testing; Texas; Therapeutic; Training; United States; Universities; Woman; acute stroke; austin; bench to bedside; career; clinical research site; design; disability; ethnic diversity; improved; metropolitan; multidisciplinary; novel; novel marker; patient population; pediatric patients; post stroke; pre-clinical; prevent; programs; randomized trial; stroke recovery; stroke therapy; stroke trials; working group

Our center for 30 years has been a leader in clinical trials testing new treatments for stroke and brain hemorrhage. In this application, we aim to continue serving as a leading regional coordinating center (RCC) in StrokeNet and have assembled a well-organized group of connected clinical sites linked by a history of productive collaboration and led by a multidisciplinary and ethnically diverse team. In Specific Aim 1, we intend to continue leading a RCC consisting of multidisciplinary teams to conduct clinical trials testing novel stroke therapies in acute stroke, stroke prevention, and stroke recovery. The UTHealth RCC will conduct clinical trials within a network of inter-connected sites throughout Texas, Oklahoma, and Louisiana, involving both adult and pediatric patients with attention to the recruitment of minorities and women. In specific Aim 2, we will continue to provide expertise and leadership for the design of novel trials and propose trials testing new stroke therapies in acute stroke, stroke prevention, and stroke recovery. We will also provide translational expertise for the development of new stroke therapies from bench to bedside and for the development and testing of novel biomarkers. In specific Aim 3, we will continue to provide a career enhancement program within our network for clinician-scientists with high potential for independent research careers in stroke.

30年来，我们的中心一直是中风和大脑新疗法临床试验的领导者。 出血在这次申请中，我们的目标是继续作为一个领先的区域协调中心， (RCC)在StrokeNet，并已组装了一个组织良好的一组连接的临床网站， 富有成效的合作历史，并由多学科和种族多元化的团队领导。在 具体目标1，我们打算继续领导一个由多学科小组组成的区域协调委员会， 在急性中风、中风预防和中风恢复中测试新中风疗法的临床试验。 UTHealth RCC将在整个互联网站网络内进行临床试验， 德克萨斯州、俄克拉荷马州和路易斯安那州，涉及成人和儿童患者， 招募少数族裔和妇女。在具体目标2中，我们将继续提供专业知识， 领导新试验的设计，并提出试验测试新的中风治疗急性 中风、中风预防和中风康复。我们还将提供翻译专业知识， 开发从实验室到床边的新中风疗法，并开发和测试 新的生物标志物。在具体目标3中，我们将继续提供职业提升计划 在我们的网络中，临床科学家具有独立研究职业的高潜力， 中风