Developmental Research Program

耶鲁大学 SPORE 皮肤癌发展研究计划 (DRP) 的主要目标是为广泛的创新皮肤癌试点项目（涉及适用于人类皮肤癌风险、预防、诊断、预后或治疗的研究、资源和技术开发）提供有限的支持（每年最多 50,000 美元，通常不超过两年）。此类可行性/试点项目必须具有有希望的转化研究潜力，即必须期望它们能够发展或纳入具有明确转化成分的完整项目，以便它们可以取代先前在该 SPORE 中资助的其他已完成或进展欠佳的项目。对于受资助的试点项目来说，另一个令人满意的结果是其发展成为一个能够成功竞争独立的投资回报率型资助的研究项目。每年总计至少 250,000 美元将用于发展研究项目（其中 100,000 美元为直接费用；100,000 美元由耶鲁大学癌症中心保证的机构配套资金，以及由皮肤科每年保证至少 50,000 美元，专门用于帮助支持将 YSPORE 初级/全面、发展或职业发展项目所取得的科学进步转化为早期临床试验。该 DRP 的目标是扩大耶鲁大学研究界积极从事人类皮肤癌相关研究的研究人员基础。在最初的五年资助期内，YSPORE DRP 资助了 16 个不同的项目（15 个与黑色素瘤相关，1 个与皮肤 T 细胞淋巴瘤相关），涉及来自 12 个不同部门的 27 名不同研究人员。另外 6 个试点项目（来自 8 个部门的 9 名研究人员）获得了更有限的支持。 YSPORE 行政核心自由支配资金。一位心怀感激的患者提供了一份非常慷慨的礼物，允许建立米尔斯坦·迈耶黑色素瘤研究中心，该中心的资金用于通过为另外五个项目（五个部门的 8 名研究人员）提供支持，进一步使 YSPORE 黑色素瘤试点/开发研究多样化。

The primary goal of the Yale SPORE in Skin Cancer Developmental Research Program (DRP) is to provide limited support (maximum of $50,000/year, typically for no more than two years) for a broad spectrum of innovative skin cancer pilot projects (involving research, resources, and technology development applicable to human skin cancer risk, prevention, diagnosis, prognosis, or treatment). Such feasibility/pilot projects must have promising translational research potential, i.e., there must be the expectation that they can evolve, or be incorporated into, full projects with an unequivocal translational component, such that they could replace other completed or sub-optimally progressing projects previously funded within this SPORE. An alternative satisfactory outcome for a funded pilot project would be its development into a research project capable of successfully competing for independent, ROI-type funding. A total of at least $250,000/year will be utilized for Developmental Research Projects ($100,000 in direct costs;, $100,000 in institutional matching funds guaranteed by the Yale Cancer Center, and at least $50,000/year guaranteed by the Department of Dermatology to specifically be used to help support translation to early phase clinical trials of scientific advances made as a result of YSPORE primary/full, developmental or career development projects. A second goal of this DRP is broaden the base of investigators within the Yale research community who are actively engaged in research related to human skin cancer. During Its initial five-year funding period, from 31 new applications for funding, the YSPORE DRP has funded 16 different projects (15 related to melanoma, 1 to cutaneous T cell lymphoma) involving 27 different investigators from 12 different departments/sections. Six additional pilot projects (9 investigators from 8 departments) received more limited support via the YSPORE Administrative Core discretionary funds. A very generous gift from a grateful patient allowed the establishment of the Milstein Meyer Center for Melanoma Research, funds from which were used to further diversify YSPORE pilot/developmental research in melanoma by providing support for five additional projects (8 investigators in five departments).