Developmental Research Program

耶鲁大学孢子皮肤癌开发研究计划(DRP)的主要目标是为一系列创新的皮肤癌试点项目(涉及适用于人类皮肤癌风险、预防、诊断、预后或治疗的研究、资源和技术开发)提供有限的支持(最高50,000美元/年，通常不超过两年)。这种可行性/试点项目必须具有有前景的翻译研究潜力，即必须期望它们能够演变或被纳入具有明确翻译成分的完整项目，以便它们能够取代以前在该孢子内资助的其他已完成或进展不佳的项目。一个由资金资助的试点项目的另一个令人满意的结果是，它将发展成为一个能够成功竞争独立的、ROI类型的资金的研究项目。每年至少有250,000美元将用于开发研究项目(100,000美元为直接成本；100,000美元由耶鲁癌症中心担保的机构匹配资金；以及至少50,000美元/年由皮肤科担保的资金，专门用于支持将YSPORE初级/全面、发展或职业发展项目所取得的科学进步转化为早期临床试验。DRP的第二个目标是扩大耶鲁大学研究界的研究人员基础，他们积极参与与人类皮肤癌相关的研究。在最初的五年资助期内，YSPORE DRP从31个新的资金申请中，资助了16个不同的项目(15个与黑色素瘤有关，1个与皮肤T细胞淋巴瘤有关)，涉及来自12个不同部门/部门的27名不同研究人员。另外6个试点项目(来自8个部门的9名调查员)通过YSPORE行政核心可自由支配基金得到了更有限的支持。一位心怀感激的患者的慷慨捐赠使米尔斯坦·迈耶黑色素瘤研究中心得以成立，该中心的资金用于通过支持另外五个项目(五个部门的8名研究人员)，进一步丰富YSPORE黑色素瘤试点/开发研究。

The primary goal of the Yale SPORE in Skin Cancer Developmental Research Program (DRP) is to provide limited support (maximum of $50,000/year, typically for no more than two years) for a broad spectrum of innovative skin cancer pilot projects (involving research, resources, and technology development applicable to human skin cancer risk, prevention, diagnosis, prognosis, or treatment). Such feasibility/pilot projects must have promising translational research potential, i.e., there must be the expectation that they can evolve, or be incorporated into, full projects with an unequivocal translational component, such that they could replace other completed or sub-optimally progressing projects previously funded within this SPORE. An alternative satisfactory outcome for a funded pilot project would be its development into a research project capable of successfully competing for independent, ROI-type funding. A total of at least $250,000/year will be utilized for Developmental Research Projects ($100,000 in direct costs;, $100,000 in institutional matching funds guaranteed by the Yale Cancer Center, and at least $50,000/year guaranteed by the Department of Dermatology to specifically be used to help support translation to early phase clinical trials of scientific advances made as a result of YSPORE primary/full, developmental or career development projects. A second goal of this DRP is broaden the base of investigators within the Yale research community who are actively engaged in research related to human skin cancer. During Its initial five-year funding period, from 31 new applications for funding, the YSPORE DRP has funded 16 different projects (15 related to melanoma, 1 to cutaneous T cell lymphoma) involving 27 different investigators from 12 different departments/sections. Six additional pilot projects (9 investigators from 8 departments) received more limited support via the YSPORE Administrative Core discretionary funds. A very generous gift from a grateful patient allowed the establishment of the Milstein Meyer Center for Melanoma Research, funds from which were used to further diversify YSPORE pilot/developmental research in melanoma by providing support for five additional projects (8 investigators in five departments).