Developmental Research Program

发展研究计划

• 批准号: 9126437
• 负责人: ROBERT E. TIGELAAR
• 金额: $ 8.84万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9126437
• 关键词: Area; Clinical Trials; Collaborations; Communities; Coupled; Cutaneous; Data; Dermatology; Development; Diagnosis; Direct Costs; Doctor of Medicine; Funding; Funding Opportunities; Future; Gifts; Goals; Human; Institutes; Leadership; Letters; Outcome; Patients; Phase; Pilot Projects; Play; Prevention; Process; Reproduction spores; Research; Research Activity; Research Contracts; Research Personnel; Research Project Grants; Resources; Role; Science; Scientific Advances and Accomplishments; Skin Cancer; Source; T-Cell Lymphoma; Translational Research; Translations; United States National Institutes of Health; Yale Cancer Center; anticancer research; base; cancer risk; career development; expectation; innovation; inter-institutional; interest; meetings; melanoma; new technology; oncology; outcome forecast; programs; technology development

The primary goal of the Yale SPORE in Skin Cancer Developmental Research Program (DRP) is to provide limited support (maximum of $50,000/year, typically for no more than two years) for a broad spectrum of innovative skin cancer pilot projects (involving research, resources, and technology development applicable to human skin cancer risk, prevention, diagnosis, prognosis, or treatment). Such feasibility/pilot projects must have promising translational research potential, i.e., there must be the expectation that they can evolve, or be incorporated into, full projects with an unequivocal translational component, such that they could replace other completed or sub-optimally progressing projects previously funded within this SPORE. An alternative satisfactory outcome for a funded pilot project would be its development into a research project capable of successfully competing for independent, ROI-type funding. A total of at least $250,000/year will be utilized for Developmental Research Projects ($100,000 in direct costs;, $100,000 in institutional matching funds guaranteed by the Yale Cancer Center, and at least $50,000/year guaranteed by the Department of Dermatology to specifically be used to help support translation to early phase clinical trials of scientific advances made as a result of YSPORE primary/full, developmental or career development projects. A second goal of this DRP is broaden the base of investigators within the Yale research community who are actively engaged in research related to human skin cancer. During Its initial five-year funding period, from 31 new applications for funding, the YSPORE DRP has funded 16 different projects (15 related to melanoma, 1 to cutaneous T cell lymphoma) involving 27 different investigators from 12 different departments/sections. Six additional pilot projects (9 investigators from 8 departments) received more limited support via the YSPORE Administrative Core discretionary funds. A very generous gift from a grateful patient allowed the establishment of the Milstein Meyer Center for Melanoma Research, funds from which were used to further diversify YSPORE pilot/developmental research in melanoma by providing support for five additional projects (8 investigators in five departments).

耶鲁大学SPORE皮肤癌发展研究项目（DRP）的主要目标是为广泛的创新皮肤癌试点项目（涉及适用于人类皮肤癌风险、预防、诊断、预后或治疗的研究、资源和技术开发）提供有限的支持（每年最高5万美元，通常不超过两年）。这样的可行性/试点项目必须具有很好的转译研究潜力，也就是说，必须期望它们能够进化，或者被纳入具有明确转译成分的完整项目中，这样它们就可以取代之前在《孢子》中资助的其他已完成或次优化进展的项目。获得资助的试点项目的另一种令人满意的结果是，它发展成为一个能够成功竞争独立的、投资回报率类型的资助的研究项目。每年至少25万美元将用于发展研究项目(10万美元为直接成本；10万美元为耶鲁癌症中心保证的机构配套资金；每年至少5万美元由皮肤学系保证，专门用于帮助支持将YSPORE初级/全面、发展或职业发展项目所取得的科学进步转化为早期临床试验。该DRP的第二个目标是扩大耶鲁研究界积极从事人类皮肤癌相关研究的研究人员的基础。在最初的五年资助期内，从31个新的资助申请中，YSPORE DRP资助了16个不同的项目（15个与黑色素瘤有关，1个与皮肤T细胞淋巴瘤有关），涉及来自12个不同部门/部门的27名不同的研究人员。另外6个试点项目（来自8个部门的9名调查人员）通过青年和社会问题中心行政核心可自由支配资金得到的支助更为有限。一位心怀感激的患者慷慨地捐赠了米尔斯坦·梅耶黑色素瘤研究中心，该中心的资金用于进一步丰富YSPORE在黑色素瘤研究方面的试点/发展研究，为另外五个项目（五个部门的8名研究人员）提供支持。