YALE SKIN DISEASE RESEARCH CORE CENTER

该申请要求为建立耶鲁皮肤基金会提供资金。 疾病研究核心中心（YSDRC），将汇集一个 由25名独立研究者组成的多学科协作小组（作为 以及其他19名协理调查员和咨询人） 皮肤科、生物学、心脏生物学、比较 医学、内分泌学、人类遗传学、免疫生物学、分子生物学 生物物理学和生物化学，肿瘤学，病理学，儿科学，药理学， 整形外科、肺内科和放射治疗学，全部共享 致力于推进对病因和发病机制的理解， 皮肤病通过调查正常和病理 皮肤的结构和功能。 YSDRC研究活动将集中在 围绕三大主题：T细胞淋巴瘤和生理性T细胞：皮肤 相互作用;黑色素细胞和黑色素瘤的生物学;以及黑色素细胞的生长和 正常和恶性角质形成细胞的分化。 三个核心单元， 每一个与其他耶鲁资源设施的互动将建立： 分子分析;细胞培养;和组织获取和 分布/生物结构和功能。 YSDRC 试点/可行性方案将加强新的发展 跨学科皮肤相关研究， 调查人员之间进行实质性合作， 利益 YSDRC浓缩计划提供了多种机会， 开展新的国家和机构合作研究。 这些 因此，每个设施/项目都将有助于实现YSDRC的 我们的主要目标是创造一个环境，大大增强我们的 了解基本的皮肤生物学以及各种各样的 皮肤病 为达致这个目标，青年发展资源中心的具体目标如下 （1）促进新的多学科互动;（2）促进新的 研究人员参与YSDRC研究的一个或多个领域; 3） 利用潜在的重要新研究机会， 跨学科试点/可行性项目; 4）组织耗时， 将昂贵的技术和程序转化为具有成本效益的核心设施 由多名研究者使用; 5）提供丰富的培训环境;以及 6)促进国家和国际合作。

This application requests funding for the establishment of the Yale Skin Disease Research Core Center (YSDRC), which will bring together a collaborative, multidisciplinary group of 25 independent Investigators (as well as 19 other Associate Investigators and Consultants) based in the departments/divisions of Dermatology, Biology, Cardiobiology, Comparative Medicine, Endocrinology, Human Genetics, Immunobiology, Molecular Biophysics and Biochemistry, Oncology, Pathology, Pediatrics, Pharmacology, Plastic Surgery, Pulmonary Medicine, and Therapeutic Radiology, all sharing a commitment to advancing understanding of the etiology and pathogenesis of skin diseases through investigation of both the normal and pathologic structure and function of skin. YSDRC research activities will center around three major themes: T cell lymphoma and physiologic T cell:skin interactions; the biology of melanocytes and melanoma; and the growth and differentiation of normal and malignant keratinocytes. Three Core units, each interacting with other Yale resource facilities will be established: Molecular Analysis; Cell Culture; and Tissue Acquisition and Distribution/Biological Structure and Function. The YSDRC pilot/feasibility program will enhance the development of new interdisciplinary skin-related investigation by requiring that projects involve substantive collaboration between investigators with complementary interests. The YSDRC enrichment program provides multiple opportunities to develop new national as well as institutional collaborative studies. These facilities/programs will thus each contribute to achieving the YSDRC's principal goal of creating an environment which will greatly amplify our understanding of basic cutaneous biology as well as of a broad variety of skin diseases. To achieve that goal, the specific aims of the YSDRC are to: 1) stimulate new multidisciplinary interactions; 2) stimulate new investigators to become involved in one or more areas of YSDRC research; 3) capitalize on potentially important new research opportunities through interdisciplinary pilot/feasibility projects; 4) organize time-consuming, expensive techniques and procedures into cost-efficient core facilities used by multiple investigators; 5) provide a rich training environment; and 6) foster national and international collaborations.