A sleep and media intervention to improve adolescents weight and risk of type 2 diabetes

项目摘要 戴维斯-福比安博士的长期目标是成为一个独立的，以病人为导向的 调查员，重点是执行和评估干预措施，以解决儿童 和青少年肥胖症，预防2型糖尿病。成功完成提供的受保护时间 K23职业发展奖将为实现这一目标提供必要的基础支持。 目标.本研究的长期目标是建立一种有效的干预措施 结合睡眠，以改善青少年健康，减少肥胖和风险， 2型糖尿病的治疗 Davis-Fobian博士是亚拉巴马大学精神病学系的助理教授 伯明翰（UAB）她的职位使她能够每天与杰出的研究人员互动， 为她提供了利用最创新技术的机会。戴维斯-福比安博士是一位经验丰富的 一位临床心理学家，在治疗患有2型糖尿病或有患2型糖尿病风险的肥胖青少年方面拥有丰富的经验 糖尿病正是通过这些临床经验，Davis-Fobian博士意识到需要新的方法 并提出了她的假设，即改善睡眠可能有助于青少年减肥 和预防2型糖尿病。 Davis-Fobian博士成功职业发展的基础是杰出的指导 她为她的项目开发了一个团队，由芭芭拉·高尔博士、大卫·艾莉森博士和凯伦·甘布尔博士组成， 她的科学顾问团他们的专业知识补充了Davis-Fobian博士将受益的所有领域 额外的训练。这些导师都是UAB的教员，有着悠久的研究历史。 合作。该奖项计划的职业发展包括1）胰岛素敏感性，β细胞 功能，时间生物学，生物统计学和临床试验研究和研究伦理; 2）实验室培训， 代谢、身体组成和时间生物学; 3）专业技能培训。这些技能将 通过课程作业，短期课程，教学机会和实践经验培养，让博士。 戴维斯-福比安最终成为全国公认的肥胖和2型糖尿病预防研究人员。 这项研究的目的是评估睡眠和媒体使用干预对身体的影响。 肥胖青少年2型糖尿病的构成和风险。这将通过2 具体目的：1）进行一项双臂平行组随机对照试验， 青少年睡眠时间和媒体使用对睡眠时间和质量、胰岛素敏感性 食欲调节激素和身体成分; 2）评估睡眠干预是否影响 青少年的夜间媒体使用在干预结束时和3个月的随访。

Project Summary Dr. Davis-Fobian's long-term goal is to become an independent, patient-oriented investigator with a focus on implementing and evaluating interventions to address childhood and adolescent obesity and prevent type 2 diabetes. Protected time provided by successful completion of this K23 career development award will provide the foundational support necessary for achievement of this goal. The long-term objective of this research is to establish an effective intervention incorporating sleep to improve adolescent health and reduce obesity and risk for the development of type 2 diabetes. Dr. Davis-Fobian is an Assistant Professor in the Department of Psychiatry at the University of Alabama at Birmingham (UAB). Her position allows her to interact with distinguished researchers on a daily basis and provides her with the opportunity to utilize the most innovative technology. Dr. Davis-Fobian is an experienced clinical psychologist who has extensive experience in treating obese adolescents with or at risk for type 2 diabetes. It was through these clinical experiences that Dr. Davis-Fobian realized the need for new approaches to obesity treatments and developed her hypothesis that improving sleep may assist in adolescent weight loss and prevention of type 2 diabetes. The foundation of Dr. Davis-Fobian's successful career development is the distinguished mentoring team she has developed for her project, consisting of Drs. Barbara Gower, David Allison and Karen Gamble and her scientific advisory panel. Their expertise complements all areas in which Dr. Davis-Fobian would benefit from additional training. These mentors are all faculty at UAB and have a strong history of research collaborations. Career development planned for this award includes 1) training in insulin sensitivity, beta-cell function, chronobiology, biostatistical and clinical trials research and research ethics; 2) laboratory training in metabolism, body composition, and chronobiology; and 3) professional skills training. These skills will be fostered through coursework, short courses, didactic opportunities and hands-on experiences, allowing Dr. Davis-Fobian to ultimately become a nationally recognized obesity and type 2 diabetes prevention researcher. The purpose of the proposed study is to assess the effects of a sleep and media use intervention on body composition and risk for type 2 diabetes in obese adolescents aged 15-17. This will be accomplished through 2 specific aims: 1) Conduct a two-arm parallel group randomized controlled trial of the relative effects of an intervention for adolescent sleep duration and media use on sleep duration and quality, insulin sensitivity, appetite-regulating hormones, and body composition; and 2) Evaluate whether the sleep intervention affects adolescents' nighttime media use at both the end of the intervention and the 3-month follow-up.