A sleep and media intervention to improve adolescents weight and risk of type 2 diabetes

项目摘要 戴维斯-福宾医生的长期目标是成为一名独立的、以患者为导向的 调查员，重点是实施和评估解决儿童问题的干预措施 预防青少年肥胖和预防2型糖尿病。成功完成所提供的保护时间 K23职业发展奖将为实现这一目标提供必要的基础支持 进球。这项研究的长期目标是建立有效的干预措施 纳入睡眠以改善青少年健康，降低肥胖和老年人的风险 二型糖尿病的发展。 戴维斯-福比安博士是阿拉巴马大学精神病学系助理教授 在伯明翰(UAB)。她的职位使她能够每天与杰出的研究人员互动， 为她提供了利用最具创新性的技术的机会。戴维斯-福宾博士是一位经验丰富的 在治疗患有或有患2型肥胖风险的肥胖青少年方面有丰富经验的临床心理学家 糖尿病。正是通过这些临床经验，戴维斯-福宾博士认识到了新方法的必要性 并提出了改善睡眠可能有助于青少年减肥的假说 和预防2型糖尿病。 戴维斯-福宾博士成功职业发展的基础是卓越的指导 她为自己的项目开发的团队，由芭芭拉·高尔博士、大卫·艾利森博士和凯伦·甘布尔博士以及 她的科学顾问团。他们的专业知识补充了戴维斯-福宾博士将受益的所有领域 来自额外的培训。这些导师都是UAB的教职员工，有很强的研究历史 合作。该奖项的职业发展计划包括1)胰岛素敏感性、β细胞 功能、时间生物学、生物统计学和临床试验研究和研究伦理；2)实验室培训 新陈代谢、身体成分和时间生物学；3)专业技能培训。这些技能将是 通过课程作业、短期课程、授课机会和实践经验培养，使Dr。 Davis-Fobian最终成为全国公认的肥胖和2型糖尿病预防研究人员。 本研究的目的是评估睡眠和媒体使用干预对身体的影响。 15-17岁肥胖青少年的组成和患2型糖尿病的风险。这将通过2个月完成 具体目标：1)进行双臂平行组随机对照试验 青少年睡眠时间和媒体使用对睡眠时间和质量、胰岛素敏感性、 食欲调节激素和身体成分；以及2)评估睡眠干预是否影响 干预结束和3个月随访时青少年夜间媒体使用情况。

Project Summary Dr. Davis-Fobian's long-term goal is to become an independent, patient-oriented investigator with a focus on implementing and evaluating interventions to address childhood and adolescent obesity and prevent type 2 diabetes. Protected time provided by successful completion of this K23 career development award will provide the foundational support necessary for achievement of this goal. The long-term objective of this research is to establish an effective intervention incorporating sleep to improve adolescent health and reduce obesity and risk for the development of type 2 diabetes. Dr. Davis-Fobian is an Assistant Professor in the Department of Psychiatry at the University of Alabama at Birmingham (UAB). Her position allows her to interact with distinguished researchers on a daily basis and provides her with the opportunity to utilize the most innovative technology. Dr. Davis-Fobian is an experienced clinical psychologist who has extensive experience in treating obese adolescents with or at risk for type 2 diabetes. It was through these clinical experiences that Dr. Davis-Fobian realized the need for new approaches to obesity treatments and developed her hypothesis that improving sleep may assist in adolescent weight loss and prevention of type 2 diabetes. The foundation of Dr. Davis-Fobian's successful career development is the distinguished mentoring team she has developed for her project, consisting of Drs. Barbara Gower, David Allison and Karen Gamble and her scientific advisory panel. Their expertise complements all areas in which Dr. Davis-Fobian would benefit from additional training. These mentors are all faculty at UAB and have a strong history of research collaborations. Career development planned for this award includes 1) training in insulin sensitivity, beta-cell function, chronobiology, biostatistical and clinical trials research and research ethics; 2) laboratory training in metabolism, body composition, and chronobiology; and 3) professional skills training. These skills will be fostered through coursework, short courses, didactic opportunities and hands-on experiences, allowing Dr. Davis-Fobian to ultimately become a nationally recognized obesity and type 2 diabetes prevention researcher. The purpose of the proposed study is to assess the effects of a sleep and media use intervention on body composition and risk for type 2 diabetes in obese adolescents aged 15-17. This will be accomplished through 2 specific aims: 1) Conduct a two-arm parallel group randomized controlled trial of the relative effects of an intervention for adolescent sleep duration and media use on sleep duration and quality, insulin sensitivity, appetite-regulating hormones, and body composition; and 2) Evaluate whether the sleep intervention affects adolescents' nighttime media use at both the end of the intervention and the 3-month follow-up.