A sleep electroencephalography biomarker predicting Alzheimer's disease pathology

项目摘要/摘要：阿尔茨海默病的早期生物标志物迫切需要至少三个 原因：（i）确定哪些人最有可能患阿尔茨海默病，从而（ii）提供 预防性干预，疾病发作前，和（iii）进一步允许早期治疗干预， 尽可能地在疾病的过程中。所有这三个目标都需要一个敏感的，非侵入性的，负担得起的，可访问的 阿尔茨海默病病理学/进展的生物标志物。为了满足这些需求，我们建议测试 假设独特的NREM睡眠EEG特征提供了Aβ病理学的候选早期生物标志物， 一种可以准确跟踪和预测阿尔茨海默病风险和阿尔茨海默病的方法， 病理生理进展如果是正确的，该提案将建立一个新颖，廉价， 在临床症状出现之前确定阿尔茨海默病风险和病理学进展的诊断工具 一个是适合社区环境的，一个是适合社区环境的。此外，这些数据将激励增加 关于在整个生命周期中治疗睡眠困难的重要性的医学意识，以及进一步 促进开发（临床或商业）基于睡眠的干预措施，改善成人睡眠 从而降低阿尔茨海默病的患病率及其社会负担。一般来说，这些发现 我主张改善公共卫生政策，倡导在整个过程中提供充足的优质睡眠。 成人-一份备忘录，可以降低痴呆症的风险，并保持整个认知健康 人口众多

Project Summary/Abstract: Early biomarkers of Alzheimer's disease are urgently required for at least three reasons: (i) to determine which individuals are at greatest Alzheimer's disease risk, thereby (ii) offering preventative intervention, pre-disease onset, and (iii) further allowing nascent treatment intervention as early as possible in the disease process. All three goals demand a sensitive, non-invasive, affordable, accessible biomarker of Alzheimer's disease pathology/progression. Addressing these needs, we propose to test the hypothesis that a unique NREM sleep EEG signature provides a candidate early biomarker of Aβ pathology, one that may accurately track and forecast Alzheimer's disease risk and Alzheimer's disease pathophysiological progression. If correct, the proposal would establish a novel, inexpensive, and early diagnostic tool for determining Alzheimer's disease risk and pathology progression before clinical symptoms emerge, and one that is suitable for community settings. Moreover, such data would motivate an increased medical awareness regarding the importance of treating sleep difficulties across the lifespan, and further motivate the development (clinical or commercial) of sleep-based interventions that improve adult sleep and thus reduce Alzheimer's disease prevalence and its societal burden. More generally, such findings would argue for improved public health policies advocating for sufficient quality sleep throughout adulthood—a memorandum that may lower dementia risk and maintain cognitive health across the populous.