A sleep electroencephalography biomarker predicting Alzheimer's disease pathology

项目摘要/摘要：至少三年内迫切需要阿尔茨海默病的早期生物标记物 原因：(I)确定哪些人患阿尔茨海默病的风险最高，从而(Ii)提供 预防性干预，发病前，以及(3)进一步允许尽早进行新生治疗干预 尽可能地在疾病过程中。所有这三个目标都要求敏感、非侵入性、负担得起、可访问的 阿尔茨海默病病理/进展的生物标志物。针对这些需求，我们建议测试 假设独特的非快速眼动睡眠脑电特征提供了β病理的候选早期生物标志物， 一种可以准确跟踪和预测阿尔茨海默病风险和阿尔茨海默病的工具 病理生理进展。如果是正确的，该提议将建立一个新颖、廉价和早期的 在临床症状出现前确定阿尔茨海默病风险和病理进展的诊断工具 Emerge，以及一种适合社区设置的。此外，这样的数据将激励增加的 对一生中治疗睡眠困难的重要性的医学认识，以及进一步 推动(临床或商业)基于睡眠的干预措施的发展，以改善成人睡眠 从而降低阿尔茨海默病的患病率及其社会负担。更广泛地说，这样的发现 会主张改善公共卫生政策，倡导在整个过程中有足够的高质量睡眠 成人期-一份备忘录，可能会降低痴呆症风险，并在整个过程中保持认知健康 人满为患。

Project Summary/Abstract: Early biomarkers of Alzheimer's disease are urgently required for at least three reasons: (i) to determine which individuals are at greatest Alzheimer's disease risk, thereby (ii) offering preventative intervention, pre-disease onset, and (iii) further allowing nascent treatment intervention as early as possible in the disease process. All three goals demand a sensitive, non-invasive, affordable, accessible biomarker of Alzheimer's disease pathology/progression. Addressing these needs, we propose to test the hypothesis that a unique NREM sleep EEG signature provides a candidate early biomarker of Aβ pathology, one that may accurately track and forecast Alzheimer's disease risk and Alzheimer's disease pathophysiological progression. If correct, the proposal would establish a novel, inexpensive, and early diagnostic tool for determining Alzheimer's disease risk and pathology progression before clinical symptoms emerge, and one that is suitable for community settings. Moreover, such data would motivate an increased medical awareness regarding the importance of treating sleep difficulties across the lifespan, and further motivate the development (clinical or commercial) of sleep-based interventions that improve adult sleep and thus reduce Alzheimer's disease prevalence and its societal burden. More generally, such findings would argue for improved public health policies advocating for sufficient quality sleep throughout adulthood—a memorandum that may lower dementia risk and maintain cognitive health across the populous.