Methods for Evaluating Vaccine Efficacy
Methods for Evaluating Vaccine Efficacy
批准号:
9042201
负责人:
M Elizabeth Halloran
金额:
$48.8万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-06-01 至 2020-05-31
关键词:
AccountingBayesian MethodCase-Control StudiesCharacteristicsCluster randomized trialCollectionComplexComputer SimulationDengueDevelopmentDiseaseEffectivenessEpidemiologic MethodsEventExposure toFutureHealth PolicyHeterogeneityHouseholdHumanImmuneImmunityIndividualInfectionInfluenzaInstructionJointsMeasuresMethodsModelingPoliciesPopulationPrimary InfectionPropertyPublic HealthRandomizedRecording of previous eventsResearchResearch DesignRiskRotavirusRotavirus VaccinesStatistical MethodsStatistical StudySurvival AnalysisTuberculosisTuberculosis VaccinesTyphoid FeverVaccinationVaccinesbaseclinical efficacycost effectivecross immunitydesigninfluenza virus vaccinemalaria transmissionmalaria transmission-blocking vaccinenovelnovel vaccinesprotective effectrandomized trialtransmission processvaccination strategyvaccine candidatevaccine effectivenessvaccine efficacyvaccine trial
中文摘要
有效估计疫苗接种的直接、间接、总和总体影响对于监管和预防接种至关重要
英文摘要
Valid estimates of the direct, indirect, total, and overall effects of vaccination are crucial for regulatory and
policy decisions. New vaccines pose new challenges for novel statistical methods and study designs. We
propose an ambitious research agenda in a collection of five main aims to develop cutting-edge methods for
currently available and future vaccines. Our methods are motivated by particular vaccines, but in most
cases are applicable to vaccines with similar characteristics. In Aim 1, we will develop novel cluster-
randomized designs for evaluating the effects of new dengue vaccines and for evaluating the indirect effects
of malaria transmission blocking candidates. In Aim 2, we will develop novel statistical methods for
estimating efficacy of multivalent vaccines under heterogeneity and analyze trials of current dengue vaccine
candidates. In Aim 3, we will develop statistical methods for evaluating and comparing general surrogates of
protection from a collection of trials. We will use these methods to explore candidate general surrogates of
rotavirus vaccines, We will develop methods for validating the immune correlate of protection of the new
meningococcal A vaccine. In Aim 4, we will develop methods to estimate vaccine efficacy for infectiousness
from a study with two levels of clustering and estimate this quantity for influenza vaccine. We will develop a
new measure of risk called potential exposure and delineate its characteristics. In Aim 5, we will develop two
novel designs for evaluating new candidate tuberculosis vaccines. The first is a randomized case-referent
design that will be a cost-effective method to evaluate new tuberculosis vaccines in large populations. The
second is a design that takes into account prior sensitization and will allow differentiation of the effects of
vaccine on disease due to primary infection or reactivation. Our novel methods of design and analysis will
have direct consequences for implementation of actual studies. The results will contribute directly to
regulatory and public health policy decisions, as well as be used "as inputs in computer simulations to explore
optimal vaccination strategies. Our research will take place in partnership with individuals and organizations
directly involved with vaccine studies.
RELEVANCE (See instructions):
Accurate assessment of direct, indirect, total, and overall effects of vaccines is crucial for regulatory and
policy decisions. The research proposed here would have direct consequences for implementing actual
studies to evaluate effects of currently available and future vaccines, and thus contribute directly to public
health. The results will also be useful for computer simulations of optimal vaccination strategies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:10436907
-
项目类别:
-
资助金额:$33.09万
-
财政年份:2020
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:10223163
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项目类别:
-
资助金额:$33.09万
-
财政年份:2020
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:10063793
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项目类别:
-
资助金额:$20.29万
-
财政年份:2020
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
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批准号:10652317
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项目类别:
-
资助金额:$33.09万
-
财政年份:2020
-
负责人:M Elizabeth Halloran
-
依托单位:
Center for Statistics and Quantitative Infectious Diseases
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批准号:9099114
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项目类别:
-
资助金额:$8.99万
-
财政年份:2014
-
负责人:M Elizabeth Halloran
-
依托单位:
Center for Statistics and Quantitative Infectious Diseases
-
批准号:9307941
-
项目类别:
-
资助金额:$250.04万
-
财政年份:2014
-
负责人:M Elizabeth Halloran
-
依托单位:
Center for Statistics and Quantitative Infectious Diseases
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批准号:8927033
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项目类别:
-
资助金额:$225.04万
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财政年份:2014
-
负责人:M Elizabeth Halloran
-
依托单位:
Acquisition and loss of Neisseria meningitidis carriage in households in Mali
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批准号:8113844
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项目类别:
-
资助金额:$8.39万
-
财政年份:2011
-
负责人:M Elizabeth Halloran
-
依托单位:
Acquisition and loss of Neisseria meningitidis carriage in households in Mali
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批准号:8234930
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项目类别:
-
资助金额:$8.36万
-
财政年份:2011
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
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批准号:8438481
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项目类别:
-
资助金额:$18.26万
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财政年份:2010
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:7761818
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项目类别:
-
资助金额:$18.92万
-
财政年份:2010
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:8041026
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项目类别:
-
资助金额:$18.92万
-
财政年份:2010
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:8234048
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项目类别:
-
资助金额:$18.92万
-
财政年份:2010
-
负责人:M Elizabeth Halloran
-
依托单位:
Summer Institute in Statistics and Modeling in Infectious Diseases
-
批准号:8607324
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项目类别:
-
资助金额:$21.54万
-
财政年份:2010
-
负责人:M Elizabeth Halloran
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依托单位:
Containing Bioterrorist and Emerging Infectious Diseases
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批准号:8269948
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项目类别:
-
资助金额:$80.46万
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财政年份:2004
-
负责人:M Elizabeth Halloran
-
依托单位:
Containing Bioterrorist and Emerging Infectious Diseases
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批准号:8531539
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项目类别:
-
资助金额:$10.6万
-
财政年份:2004
-
负责人:M Elizabeth Halloran
-
依托单位:
Containing Bioterrorist and Emerging Infectious Diseases
-
批准号:8211654
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项目类别:
-
资助金额:$10.0万
-
财政年份:2004
-
负责人:M Elizabeth Halloran
-
依托单位:
Containing Bioterrorist and Emerging Infectious Diseases
-
批准号:8070052
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项目类别:
-
资助金额:$89.35万
-
财政年份:2004
-
负责人:M Elizabeth Halloran
-
依托单位:
Containing Bioterrorist and Emerging Infectious Diseases
-
批准号:8134104
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项目类别:
-
资助金额:$15.0万
-
财政年份:2004
-
负责人:M Elizabeth Halloran
-
依托单位:
Containing Bioterrorist and Emerging Infectious Diseases
-
批准号:7931030
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项目类别:
-
资助金额:$15.0万
-
财政年份:2004
-
负责人:M Elizabeth Halloran
-
依托单位:
海外基金