Interdisciplinary Program in Microbe-Host Biology

描述（由申请人提供）：当今的现实包括多重耐药生物体和新感染因子的出现和传播，对全球流行病的日益关注，在进攻性生物战中使用感染因子，以及机会性感染的扩大。这些对人类健康的挑战需要为下一代科学家提供全面的跨学科培训计划来研究微生物 主机接口。培训教师来自三个学院和几个不同的部门。该项目的中心将是俄亥俄州州立大学微生物界面生物学中心（CMIB），该中心专注于宿主病原体研究。其中一位PI（MPI机制）是一位医生科学家，担任CMIB主任和医学院微生物感染和免疫（MI&I）新部门的主席，另一位PI是博士科学家和CMIB副主任/MI&I副主席，都有强大的研究计划和职业生涯专注于教育。因此，PI代表了一个杰出的，建立了合作团队，以监督这一广泛的创新计划，强调：1）高度互动的科学界，2）多学科的科学方法，3）学员接触大型学术健康科学中心的生物医学研究界，4）临床和基础科学的整合，5）接触经验丰富和有才华的科学家教育家和导师，以及6）几个额外的优势，研究员，包括当地和国际实习计划。主要的专题领域是1）微生物对感染的反应; 2）宿主对感染的反应（免疫，呼吸生物学）; 3）生物膜;和4）药物发现。该计划描述了一个选择和监督委员会，一个杰出的，从事外部咨询委员会和必要的行政结构，以执行该计划。重点是招聘多样性受训人员和正式指导负责任地进行研究。我们要求3个博士前，2个博士后和1个短期临床学者插槽/年。我们相信，课程，教师，资源和机构的支持使该计划对优秀的学生有吸引力，他们将获得独特的多学科培训经验，重点是微生物-主机界面，并为他们在生物医学劳动力的广度职业生涯做好准备。

DESCRIPTION (provided by applicant): Today's reality includes emergence and spread of multi-drug resistant organisms and new infectious agents, a growing concern for worldwide pandemics, the use of infectious agents in offensive bio-warfare, and an enlarging list of opportunistic infections. These challenges to human health necessitate comprehensive interdisciplinary training programs for the next generation of scientists in studies of the microbe host interface. The training faculty are from three colleges and several different departments. The hub for the program will be the Ohio State University Center for Microbial Interface Biology (CMIB), which is focused on Host-Pathogen Research. One of the PIs (MPI mechanism) is a physician scientist who serves as Director of the CMIB and Chair of a new Department in the Medical School, Microbial Infection and Immunity (MI&I), and the other PI is a PhD scientist and CMIB Vice-Director/MI&I Vice-Chair, both with strong research programs and careers focused on education. Thus the PIs represent an outstanding, established collaborative team to oversee this broad innovative program which emphasizes: 1) a highly interactive scientific community, 2) a multidisciplinary approach to science, 3) exposure of trainees to the biomedical research community of a large academic health sciences center, 4) integration of the clinical and basic sciences, 5) exposure to experienced and talented scientist educators and mentors, and 6) several added advantages to Fellows, including a local and international externship program. The major thematic areas are 1) Microbial response to infection; 2) Host response to infection (immunity, respiratory biology); 3) Biofilms; and 4) Drug discovery. The program describes a Selection and Oversight Committee, an outstanding, engaged External Advisory Committee and the necessary administrative structure to execute the program. Emphasis is placed on the recruitment of diversity trainees and on formal instruction for the responsible conduct of research. We request 3 pre-doctoral, 2 post-doctoral and 1 short-term clinical scholar slots/year. We believe that the curriculum, faculty, resources, and institutional support make this program attractive to outstanding students who will receive a unique multidisciplinary training experience focused on the microbe-host interface and prepare them for a career in the breadth of the biomedical workforce.