Interdisciplinary Program in Microbe-Host Biology

描述(申请人提供)：今天的现实包括多重耐药生物体和新的感染剂的出现和传播，对全球大流行的日益关注，在攻击性生物战中使用感染剂，以及越来越多的机会性感染。这些对人类健康的挑战需要为下一代研究微生物的科学家提供全面的跨学科培训计划 主机接口。培训人员来自三所学院和几个不同的系。该计划的中心将是俄亥俄州立大学微生物界面生物学中心(CMIB)，该中心专注于宿主-病原体研究。其中一名PI(MPI机制)是一名内科科学家，担任CMIB主任和医学院微生物感染和免疫(MI&I)新系主任，另一名PI是博士科学家和CMIB副主任/MI&I副主席，两人都有强大的研究计划和专注于教育的职业。因此，PIs代表了一支杰出的、成熟的合作团队，以监督这一广泛的创新计划，该计划强调：1)高度互动的科学社区，2)多学科的科学方法，3)学员接触大型学术健康科学中心的生物医学研究社区，4)临床和基础科学的整合，5)接触有经验和有才华的科学家教育者和导师，6)增加研究员的几个优势，包括本地和国际外部奖学金计划。主要主题领域是1)微生物对感染的反应；2)宿主对感染的反应(免疫、呼吸生物学)；3)生物膜；以及4)药物发现。该方案描述了一个遴选和监督委员会、一个杰出的、积极参与的外部咨询委员会以及执行该方案所需的行政结构。重点是招募多样化的受训人员，并为负责任的研究行为提供正式指导。我们要求每年3个博士后、2个博士后和1个短期临床学者名额。我们相信，课程、师资、资源和机构支持使该项目对优秀学生具有吸引力，他们将接受专注于微生物-宿主界面的独特多学科培训体验，并为在广泛的生物医学劳动力队伍中的职业生涯做好准备。

DESCRIPTION (provided by applicant): Today's reality includes emergence and spread of multi-drug resistant organisms and new infectious agents, a growing concern for worldwide pandemics, the use of infectious agents in offensive bio-warfare, and an enlarging list of opportunistic infections. These challenges to human health necessitate comprehensive interdisciplinary training programs for the next generation of scientists in studies of the microbe host interface. The training faculty are from three colleges and several different departments. The hub for the program will be the Ohio State University Center for Microbial Interface Biology (CMIB), which is focused on Host-Pathogen Research. One of the PIs (MPI mechanism) is a physician scientist who serves as Director of the CMIB and Chair of a new Department in the Medical School, Microbial Infection and Immunity (MI&I), and the other PI is a PhD scientist and CMIB Vice-Director/MI&I Vice-Chair, both with strong research programs and careers focused on education. Thus the PIs represent an outstanding, established collaborative team to oversee this broad innovative program which emphasizes: 1) a highly interactive scientific community, 2) a multidisciplinary approach to science, 3) exposure of trainees to the biomedical research community of a large academic health sciences center, 4) integration of the clinical and basic sciences, 5) exposure to experienced and talented scientist educators and mentors, and 6) several added advantages to Fellows, including a local and international externship program. The major thematic areas are 1) Microbial response to infection; 2) Host response to infection (immunity, respiratory biology); 3) Biofilms; and 4) Drug discovery. The program describes a Selection and Oversight Committee, an outstanding, engaged External Advisory Committee and the necessary administrative structure to execute the program. Emphasis is placed on the recruitment of diversity trainees and on formal instruction for the responsible conduct of research. We request 3 pre-doctoral, 2 post-doctoral and 1 short-term clinical scholar slots/year. We believe that the curriculum, faculty, resources, and institutional support make this program attractive to outstanding students who will receive a unique multidisciplinary training experience focused on the microbe-host interface and prepare them for a career in the breadth of the biomedical workforce.