MHAS Cognitive Aging Ancillary Study

 墨西哥健康与老龄化研究（MHAS）是一项针对墨西哥50岁及以上人群的全国性纵向研究，数据分为三波，涵盖2001年至2012年，第四波计划于2015年进行。自成立以来，MHAS与美国的健康与退休研究（HRS）具有高度可比性，使用类似的协议和调查内容。拟议项目的总体目标是，与全球使用国家样本和基于人口的方法进行的类似研究合作，以统一的方法评估墨西哥痴呆症和其他认知障碍的患病率和风险因素。具体目标是：1）通过启动墨西哥全国老年人样本的辅助研究，促进全球痴呆症研究的协调。2)通过使用可比数据分析战略和方法，与其他国家协调一致，估计墨西哥全国痴呆症和认知障碍的患病率。3)最大限度地利用MHAS数据进行跨国痴呆症研究，通过存档，记录和传播辅助研究数据库及其产生的构造变量。辅助研究将包括约3，000名受试者，即完整MHAS wave-4样本的子样本。辅助访谈的数据库将包括深度认知评估和生物标志物、人体测量和性能测试的结果。协调统一的目标将通过与美国健康和退休研究的研究人员开展的“协调项目”合作，并通过他们与世界其他地区的类似研究进行合作来实现。我们将尽可能地协调，从实地工作培训材料到数据清理，无应答的治疗，以及从辅助研究到完整MHAS样本的交叉步行方法，以估计痴呆症和其他认知障碍的全国患病率。拟议在墨西哥进行的辅助研究将进一步增强母研究MHAS的分析能力，从而能够对痴呆症的风险因素和后果进行严格的跨国检查，这是一种正在迅速老龄化的发展中国家正在研究的疾病。

 DESCRIPTION (provided by applicant): The Mexican Health and Aging Study (MHAS) is a national longitudinal study of individuals aged 50 and older in Mexico, with three waves of data covering from 2001 to 2012, and wave-4 planned for 2015. Since its inception, the MHAS has been highly comparable to the Health and Retirement Study (HRS) in the United States, using similar protocols and survey contents. The overall goal of the proposed project is to assess the prevalence and risk factors of dementia and other cognitive impairments in Mexico with a harmonized approach, working with similar studies globally that use national samples and a population-based approach. The specific aims are: 1) Contribute to harmonization in the global study of dementia by launching an ancillary study of the national sample of older adults in Mexico, the MHAS. 2) Estimate the national prevalence of dementia and cognitive impairment in Mexico, harmonized with other countries, by using comparable data analysis strategies and methods. 3) Maximize the utilization of the MHAS data for cross-national dementia studies, by archiving, documenting, and disseminating the ancillary study databases and its resulting constructed variables. The ancillary study will include approximately 3,000 subjects, a sub-sample of the full MHAS wave-4 sample. The databases for the ancillary interview will include results from in-depth cognitive assessments and biomarkers, anthropometric measures, and performance tests. The harmonization goal will be achieved by collaborating with a `coordination project' conducted by researchers of the Health and Retirement Study (HRS) in the United States and through them, with the family of similar studies in the rest of the world. We will harmonize as much as possible, from the fieldwork training materials to the data cleaning, treatment of non-response, and methods used to cross-walk from the ancillary study to the full MHAS sample to estimate national prevalence of dementia and other cognitive impairments. The proposed ancillary study in Mexico will further enhance the analytical power of the parent study MHAS, enabling rigorous cross-national examination of the risk factors and consequences of dementia, an under- studied condition in developing countries that are aging rapidly.