Mechanisms of Eukaryotic Gene Regulation

 描述（由申请人提供）：Kadonaga实验室研究的长期目标是了解双侧（双侧对称动物）中RNA聚合酶II转录的调节机制。为什么研究基因表达很重要？对基因表达的透彻理解是必不可少的，因为各种生物现象（包括许多人类疾病，如某些癌症）的基础可以追溯到基因或基因组的正确或不正确表达。因此，对基因表达机制的新见解将对广泛的生物学研究产生广泛的影响。Kadonaga实验室试图探索染色质和转录中新的且经常被低估的前沿领域。通过这种方式，他们已经能够对基因调控的理解做出一些独特的贡献。在未来，他们计划研究基础转录过程机制的多样性以及染色质，特别是非核小体含组蛋白结构在基因表达调控中的作用。这些主题将被单独研究，以及在演唱会，以获得最好的了解基因是如何在双细胞，如果蝇和人类的调控。

 DESCRIPTION (provided by applicant): The long-term objective of the research in the Kadonaga laboratory is to understand the mechanisms of regulation of RNA polymerase II transcription in bilateria (bilaterally-symmetric animals). Why is it important to study gene expression? A thorough understanding of gene expression is essential because the basis of a diverse range of biological phenomena (including many human diseases such as some cancers) can be traced to the proper or improper expression of a gene or set of genes. Thus, new insights into the mechanisms of gene expression will have a broad impact upon a wide range of biological research. The Kadonaga lab has sought to explore new and often underappreciated frontiers in chromatin and transcription. In this manner, they have been able to make a number of unique contributions to the understanding of gene regulation. In the future, they plan to study the diversity of mechanisms of the basal transcription process and the role of chromatin, particularly non-nucleosomal histone-containing structures, in the regulation of gene expression. These topics will be studied both individually as well as in concert to gain the best possible understanding of how genes are regulated in bilateria such as Drosophila and humans.