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Total Synthesis of [15N] - Cylindrospermopsin for Monitoring Fresh Water Safety

Total Synthesis of [15N] - Cylindrospermopsin for Monitoring Fresh Water Safety
[15N]-圆柱精蛋白的全合成用于监测淡水安全
批准号:
9043894
负责人:
Armen Zakarian
金额:
$7.68万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-04-01 至 2017-03-31

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): Cylindrospermopsin is a potent hepatotoxin produced by freshwater cyanobacteria. Blooms of cyanobacteria have recently increased dramatically, likely due to the rise in global temperatures and eutrophication. Release of the toxin into water that is subsequently ingested can lead to liver damage, potentially fatal. Monitoring the levels of cylindrospermopsin (CYN) in freshwater has become a human health issue, and is a subject of recent reports by the US Environmental Protection Agency and USDA. The problem is that accurate quantitative measurements of CYN concentration requires pure, isotopically labeled analytical standards, which can be used in isotope dilution mass-spectrometric assays. Producing this standard from cultures of cyanobacteria using feeding with labeled additives proved to be tedious, unreliable, and lengthy (over 2 years before results are known) process. This project proposes to access the analytical standard by total chemical synthesis, which holds a promise as a reliable source of the much-needed material. Our lab has a strong expertise in producing isotopically labeled complex molecules, including natural products, by total synthesis.
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Total Synthesis of Bioactive Marine Natural Products
Total Synthesis of Bioactive Marine Natural Products
Total Synthesis of Bioactive Marine Natural Products
Total Synthesis of Bioactive Marine Natural Products
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