FASEB SRC on IgE and Allergy: 50 Years and Onward

项目摘要/摘要 这个应用程序的目标是确保为即将到来的FASE夏季会议提供资金 过敏症：50年及以后。顾名思义，这次会议将在发现 IGE发起了一个完整的领域，专注于了解这种免疫球蛋白在慢性病中的作用 如过敏性哮喘、食物过敏、过敏性鼻炎和过敏性皮炎。今天，世界卫生组织 世界卫生组织(WHO)估计，全球有2.5亿哮喘患者，其中包括室内和 户外过敏原起着主要作用。儿科过敏症的迅速上升是对 儿童健康。为了迎接这些流行病规模的挑战，世界各地的过敏症研究人员密集地 研究过敏的基本机制，并将其结果转化为临床。重要研究领域 包括与过敏原介导的IgE受体交联有关的复杂信号通路，以及 肥大细胞和嗜碱性粒细胞的细胞生物学。在这一领域继续取得重大进展，例如 了解与2000多种已知过敏原结合的IgE结合受体的结构-功能关系。 除了免疫治疗的新策略，通向成功的新疗法的途径也是重点 了解和靶向免疫细胞、趋化因子和细胞因子之间的复杂相互作用 推动过敏性炎症和T辅助细胞-2(TH2)细胞极化。组织特异性重塑和修复的作用 屏障功能，特别是皮肤和肺的上皮细胞，突出了了解 建立和维持过敏性疾病的环境和遗传风险因素。会议的日程安排 纪念这一发现的周年纪念日，并承认过敏研究的跨学科性质 今天。到目前为止，有35个已确认的受邀会谈，代表了该领域以及早期和中期的领导人 职业调查员。该计划包括关于主要技术进步的演讲，包括 用最先进的显微镜在体外和体内成像过敏和过敏的起始事件 疾病，以及目前的动物模型和临床经验。R13将重要地支持 为受训人员和年轻研究人员提供更多在会议上发言的机会，包括简短的演讲和 《闪电》海报展示。会议将于2016年7月24日至29日在FASB-选定的 会议地点：佛罗里达州西棕榈滩万豪酒店。FASEB夏季会议的形式非常适合这一点 会议，因为参与者之间的互动由会议的规模来确保，海报会议与 陪同接待和分享餐点。“与专家见面”午餐会将促进两人之间的联系 年轻的研究人员和高级研究人员。组织者的目标是利用这次会议鼓励密集的 科学讨论，推动国际社会发展新的生产力互动 科学界从事过敏症研究。

Project Summary/Abstract The goal of this application is to secure funding for the upcoming FASEB summer conference on “IgE and Allergy: 50 Years and Onward.” As the title implies, this meeting will be held 50 years after the discovery of IgE, launching an entire field focused on understanding the roles for this immunoglobulin in chronic diseases such as allergic asthma, food allergy, allergic rhinitis and allergic dermatitis. Today, the World Health Organization (WHO) estimates that there are 250 million asthma sufferers worldwide, with both indoor and outdoor allergens playing a major role. The rapid rise in pediatric allergies represents a major threat to children’s health. To meet these epidemic-scale challenges, allergy researchers worldwide are intensively studying the basic mechanisms of allergy and translating their findings into the clinic. Important research areas include the complex signaling pathways linked to allergen-mediated crosslinking of IgE receptors, as well as the cell biology of mast cells and basophils. Major advances continue to be made in this area, such as understanding the structure-function relationships of IgE-bound receptors bound to over 2000 known allergens. In addition to new strategies for immunotherapy, the path to successful new therapies is also focused on understanding and targeting the complex interplay of immune cells, chemokines and cytokines involved in driving allergic inflammation and T-helper-2 (TH2) cell polarization. Roles for tissue-specific remodeling and barrier function, particularly epithelial cells of the skin and lung, highlight the need to understand the environmental and genetic risk factors that establish and sustain allergic diseases. The meeting’s program commemorates the anniversary of the discovery and recognizes the interdisciplinary nature of allergy research today. Thus far, there are 35 confirmed invited talks, representing leaders in the field as well as early- and mid- career investigators. Included on the program are presentations on major technological advances, including state-of-the-art microscopy employed in vitro and in vivo to image initiating events in allergy and allergic diseases, as well as current animal models and clinical experiences. The R13 will importantly support additional opportunities for trainees and young investigators to speak at the conference with short talks and “lightning” poster presentation. The conference will be held on July 24-29, 2016, at the FASEB-selected conference site, West Palm Beach Marriott, Florida. The FASEB summer conference format is ideal for this meeting, since interactions between participants is ensured by the size of the meeting, poster sessions with accompanying reception and shared meals. A “meet the expert” luncheon will foster connections between young investigators and senior researchers. The organizers’ goal is to use this meeting to encourage intensive scientific discussion and to promote the development of new productive interactions among the international scientific community engaged in allergy research.