FASEB SRC on IgE and Allergy: 50 Years and Onward

项目总结/摘要 该申请的目的是为即将举行的FASEB夏季会议“IgE和 过敏症：50年及以后。正如标题所暗示的，这次会议将在发现 IgE，启动了一个专注于了解这种免疫球蛋白在慢性疾病中的作用的整个领域 如过敏性哮喘、食物过敏、过敏性鼻炎和过敏性皮炎。今天，世界卫生 世界卫生组织（WHO）估计，全世界有2.5亿哮喘患者，无论是在室内还是在室外， 户外过敏原起主要作用。儿童过敏症的迅速增加是对儿童健康的一个主要威胁。 儿童健康。为了应对这些巨大的挑战，世界各地的过敏研究人员正在加紧研究 研究过敏的基本机制，并将他们的发现转化为临床。重要研究领域 包括与过敏原介导的IgE受体交联相关的复杂信号传导途径，以及 肥大细胞和嗜碱性粒细胞的细胞生物学。在这一领域继续取得重大进展，例如 了解与2000多种已知过敏原结合的IgE结合受体的结构-功能关系。 除了免疫治疗的新策略，成功的新疗法的途径也集中在 了解和靶向免疫细胞，趋化因子和细胞因子的复杂相互作用， 驱动过敏性炎症和辅助性T细胞2（TH 2）极化。组织特异性重塑的作用， 屏障功能，特别是皮肤和肺的上皮细胞，强调需要了解 环境和遗传风险因素，建立和维持过敏性疾病。会议日程 纪念发现周年，并承认过敏研究的跨学科性质 今天到目前为止，有35个确认的邀请会谈，代表该领域的领导人以及早期和中期， 职业调查员该计划包括介绍主要技术进步，包括 最先进的显微镜在体外和体内用于成像过敏和过敏性疾病中的起始事件 疾病，以及目前的动物模型和临床经验。R13将支持 为受训人员和年轻调查人员提供更多机会在会议上发表简短讲话， “闪电”海报介绍。会议将于2016年7月24日至29日在FASEB选定的 会议地点，西棕榈滩万豪酒店，佛罗里达。FASEB夏季会议的形式是理想的， 会议，因为与会者之间的互动是由会议的规模，海报会议， 陪同接待和共同用餐。“会见专家”午餐会将促进 年轻的研究人员和资深的研究人员。组织者的目标是利用这次会议， 科学讨论，促进国际社会之间发展新的富有成效的互动关系， 从事过敏症研究的科学界。

Project Summary/Abstract The goal of this application is to secure funding for the upcoming FASEB summer conference on “IgE and Allergy: 50 Years and Onward.” As the title implies, this meeting will be held 50 years after the discovery of IgE, launching an entire field focused on understanding the roles for this immunoglobulin in chronic diseases such as allergic asthma, food allergy, allergic rhinitis and allergic dermatitis. Today, the World Health Organization (WHO) estimates that there are 250 million asthma sufferers worldwide, with both indoor and outdoor allergens playing a major role. The rapid rise in pediatric allergies represents a major threat to children’s health. To meet these epidemic-scale challenges, allergy researchers worldwide are intensively studying the basic mechanisms of allergy and translating their findings into the clinic. Important research areas include the complex signaling pathways linked to allergen-mediated crosslinking of IgE receptors, as well as the cell biology of mast cells and basophils. Major advances continue to be made in this area, such as understanding the structure-function relationships of IgE-bound receptors bound to over 2000 known allergens. In addition to new strategies for immunotherapy, the path to successful new therapies is also focused on understanding and targeting the complex interplay of immune cells, chemokines and cytokines involved in driving allergic inflammation and T-helper-2 (TH2) cell polarization. Roles for tissue-specific remodeling and barrier function, particularly epithelial cells of the skin and lung, highlight the need to understand the environmental and genetic risk factors that establish and sustain allergic diseases. The meeting’s program commemorates the anniversary of the discovery and recognizes the interdisciplinary nature of allergy research today. Thus far, there are 35 confirmed invited talks, representing leaders in the field as well as early- and mid- career investigators. Included on the program are presentations on major technological advances, including state-of-the-art microscopy employed in vitro and in vivo to image initiating events in allergy and allergic diseases, as well as current animal models and clinical experiences. The R13 will importantly support additional opportunities for trainees and young investigators to speak at the conference with short talks and “lightning” poster presentation. The conference will be held on July 24-29, 2016, at the FASEB-selected conference site, West Palm Beach Marriott, Florida. The FASEB summer conference format is ideal for this meeting, since interactions between participants is ensured by the size of the meeting, poster sessions with accompanying reception and shared meals. A “meet the expert” luncheon will foster connections between young investigators and senior researchers. The organizers’ goal is to use this meeting to encourage intensive scientific discussion and to promote the development of new productive interactions among the international scientific community engaged in allergy research.