Intellectual and Developmental Disabilities Research Centers 2013

这份修订后的申请申请继续支持智力和发育障碍研究 肯尼迪·克里格研究所和约翰·霍普金斯大学的国际数据与发展中心(IDDRC)是对 RFA-HD-14-012。国际发展与发展中心将继续支持一个大型、多样化和多学科的 研究重点是发展障碍，重点是翻译研究，作为 Nexus for Research专注于一流的教育、临床和教育领域内的发育障碍研究 世界上的生物医学研究机构。IDDRC将包括六个核心。行政核心(A) 将为中心提供领导、管理和组织支持；协调教育 方案组成部分(讲座和研讨会)；代表中心与研究所和 大学行政管理；并充当与NICHD、其他IDDRC和 更广泛的社区。临床翻译核心(B)将支持中心调查人员与以下活动相关的活动 参与者招募、与IRB相关的活动、生物统计和整个翻译过程中的移动结果 路径。遗传学核心(C)将提供集中的组织培养和细胞遗传学方面的协助， 专门的分子遗传学、微阵列和测序研究以及生物信息学。翻译家 神经科学核心(D)将提供组织学和临床前成像设施，以及一组高度 针对与发育障碍相关的代谢物和分子的专门分析。一个 神经成像核心(E)将为调查人员提供获取和定量分析 来自泛函、体积、扩散张量和光谱磁共振成像的数据，以及 采用TMS方法的研究。最后，行为科学核心(F)将为参与者提供以下培训 与研究方案合作，选择神经心理/认知评估的方法， 设计功能磁共振成像的激活范例，以及评估运动功能的专门方法。堆芯 明年将向69个项目提供支持，每年联邦资金超过34美元 100万美元，外加由该中心直接资助的研究部分。

This revised application for continued support of the Intellectual and Developmental Disabilities Research Center (IDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-14-012. The IDDRC will continue supporting a large, diverse and multidisciplinary program of research focused on developmental disorders with an emphasis on translational research, serving as the nexus for research focused on developmental disabilities within one of the premiere educational, clinical, and biomedical research institutions in the world. The IDDRC will include six Cores. An Administrative Core (A) will provide leadership, management, and organizational support for the Center; coordinate educational program components (lectures and seminars); represent the Center In Interactions with Institute and University administration; and serve as the interface with colleagues at NICHD, other IDDRCs, and the broader community. A Clinical Translational Core (B) will support Center investigators in activities related to participant recruitment, IRB-related activities, biostatistics and moving findings along the entire translational pathway. A Genetics Core (C) will provide centralized tissue culture and assistance with cytogenetics, specialized molecular genetics, microarray and sequencing studies, and bioinformatics. A Translational Neuroscience Core (D) will provide histology and preclinical imaging facilities, as well as a group of highly specialized assays that target metabolites and molecules of relevance to developmental disorders. A Neuroimaging Core (E) will provide Investigators with assistance in acquisition and quantitative analysis of data derived from functional, volumetric, diffusion tensor, and spectroscopic MR imaging, as well as for studies employing TMS methods. Finally, a Behavior Science Core (F) will offer training of participants for cooperation with research protocols, selection of methods for neuropsychological/cognitive assessment, design of activation paradigms for fMRI, and specialized methods for assessment of motor functioning. Core support this coming year will be provided to 69 projects representing annual federal funding of over $34 million, plus a Research Component funded directly by the Center.