Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During Puberty

描述（由申请人提供）：这是一份新提交的K24职业中期研究者奖，用于以患者为导向的研究，以支持Scott里德博士的指导、研究和职业发展活动。里德博士是威斯康星大学麦迪逊分校的副教授，主要从事放射学工作，并在医学、医学物理学和生物医学工程系交叉任职。里德博士于2005年抵达威斯康星大学麦迪逊分校后，创立了一个以患者为导向的研究项目，用于开发和翻译先进的MRI方法并将其应用于临床实践。他领导着华盛顿大学肝脏成像研究项目，这是一个由NIDDK资助的活跃小组，开发和验证先进的MRI方法，以改善腹部疾病的诊断。该小组专注于弥漫性肝病的定量MRI生物标志物的验证，包括量化腹部肥胖和肝脏脂肪，肝脏铁过载的方法，以及评估门静脉高压症患者肝脏血流动力学的非侵入性方法。在过去的8年里，里德博士在威斯康星大学麦迪逊分校担任临床MRI奖学金主任，并在他担任威斯康星大学医学博士/博士项目副主任的新角色中发挥了重要的指导作用。他指导了大量的医学生，居民，临床研究员，研究生，博士后研究员和客座教授在各种各样的以病人为导向的成像项目。这些项目大多是跨学科的重点和博士里德已经建立了良好的合作与儿科内分泌学，急诊医学，肝病学，血液学和移植手术等。里德博士也是华盛顿大学MRI的医学主任。他结合临床和研究领导作用，使他能够建立一个蓬勃发展的指导环境，以病人为导向的成像研究。来自K24奖的支持将为里德博士提供所需的专门时间，通过将他从临床和行政责任中解放出来，指导临床医生进行以患者为导向的研究。里德博士还将继续他的NIDDK资助的R 01项目，并参与负责任的研究活动。他还将追求职业发展计划，包括肝病和代谢综合征的额外培训，以及以患者为中心的结果研究。最后，他将进行一个以社区为基础的以患者为导向的研究项目，研究定量MRI生物标志物在学龄女孩青春期异位腹部脂肪和胰岛素抵抗演变中的作用。这项跨学科研究将作为与儿科内分泌学初级研究者正在进行的指导合作的一部分进行。鉴于威斯康星大学麦迪逊分校的杰出环境和这种良好的指导关系，该项目预计将为未来的建议奠定基础，包括为里德博士的儿科内分泌学学员颁发K23职业发展奖，并将为青春期胰岛素抵抗和异位腹部脂肪沉积提供令人兴奋的新科学见解。

DESCRIPTION (provided by applicant): This is a new submission for a K24 mid-career investigator award in patient-oriented research to support the mentoring, research and career development activities of Dr. Scott Reeder. Dr. Reeder is an Associate Professor at the University of Wisconsin-Madison, with a primary appointment in Radiology and cross- appointments in the Departments of Medicine, Medical Physics, and Biomedical Engineering. After his arrival at UW-Madison in 2005, Dr. Reeder founded a patient-oriented research program for the development and translation of advanced MRI methods into clinical practice. He leads the UW Liver Imaging Research Program, an active NIDDK-funded group developing and validating advanced MRI methods for improved diagnosis of abdominal diseases. The group is focused on validation of quantitative MRI biomarkers of diffuse liver disease, including methods to quantify abdominal adiposity and liver fat, liver iron overload, and non-invasive methods to evaluate the hemodynamics of the liver in patients with portal hypertension. Dr. Reeder has played a major mentoring role at UW-Madison as the Director of the Clinical MRI fellowship for the past 8 years and in his new role as Associate Director of the UW MD/PhD program. He has mentored a large number of medical students, residents, clinical fellows, graduate students, post-doctoral fellows and visiting professors in a wide variety of patient-oriented imaging projects. Most of these projects are interdisciplinary in focus and Dr. Reeder has built well-established collaborations with Pediatric Endocrinology, Emergency Medicine, Hepatology, Hematology, and Transplant Surgery, among others. Dr. Reeder is also the Medical Director of MRI at UW. His combined clinical and research leadership roles have enabled him to build a thriving mentoring environment for patient- oriented imaging research. Support from a K24 award would provide Dr. Reeder with the dedicated time needed to mentor clinicians performing patient-oriented research by freeing him from clinical and administrative responsibilities. Dr. Reeder will also continue his NIDDK funded R01 projects and participate in responsible conduct of research activities. He will also pursue a career development plan that includes additional training in liver disease and metabolic syndrome, as well as patient-centered outcomes research. Finally, he will perform a community-based patient-oriented research project examining the role of quantitative MRI biomarkers in the evolution of ectopic abdominal fat and insulin resistance during puberty in school-age girls. This interdisciplinary study will be performed as part of an ongoing mentorship-collaboration with a junior investigator in Pediatric Endocrinology. Given the outstanding environment at UW-Madison and this well- established mentoring relationship, this project is expected to lay the groundwork for future proposals including a K23 career development award for Dr. Reeder's mentee in Pediatric Endocrinology and will provide exciting new scientific insight into insulin resistance and ectopic abdominal fat deposition during puberty.