Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During Puberty

描述(由申请人提供)：这是一份新提交的K24职业生涯中期研究员奖，旨在支持Scott Reeder博士的指导、研究和职业发展活动。Reeder博士是威斯康星大学麦迪逊分校的副教授，主要任职于放射学，并在医学系、医学物理系和生物医学工程系进行交叉任命。2005年来到威斯康星大学麦迪逊分校后，Reeder博士创建了一个以患者为中心的研究计划，旨在开发先进的核磁共振方法并将其转化为临床实践。他领导着华盛顿大学肝脏成像研究计划，这是一个由NIDDK资助的活跃的小组，开发和验证先进的MRI方法，以改进腹部疾病的诊断。该小组专注于弥漫性肝病的定量MRI生物标志物的验证，包括量化腹部肥胖和肝脏脂肪、肝脏铁负荷的方法，以及评估门静脉高压症患者肝脏血流动力学的非侵入性方法。在过去的8年里，Reeder博士在威斯康星大学麦迪逊分校担任临床核磁共振研究金主任，并在担任威斯康星大学医学博士项目副主任的新职位上发挥了重要的指导作用。他在各种面向患者的影像项目中指导了大量的医学生、住院医生、临床研究员、研究生、博士后研究员和客座教授。这些项目大多是跨学科的，Reeder博士与儿科内分泌学、急诊医学、肝病学、血液学和移植外科等建立了良好的合作关系。里德博士也是威斯康星大学核磁共振医学主任。他的临床和研究领导角色相结合，使他能够为以患者为导向的成像研究建立一个蓬勃发展的指导环境。来自K24奖项的支持将为里德博士提供所需的专门时间，通过将他从临床和行政责任中解放出来，指导进行以患者为导向的研究的临床医生。Reeder博士还将继续他的NIDDK资助的R01项目，并参与负责任的研究活动。他还将推行一项职业发展计划，其中包括肝脏疾病和代谢综合征方面的额外培训，以及以患者为中心的结果研究。最后，他将开展一项以社区为基础、以患者为导向的研究项目，考察定量核磁共振生物标记物在学龄女孩青春期异位腹部脂肪和胰岛素抵抗演变中的作用。这项跨学科研究将作为正在进行的指导-与儿科内分泌学初级研究员合作的一部分进行。鉴于威斯康星大学麦迪逊分校出色的环境和良好的指导关系，该项目预计将为未来的提案奠定基础，包括为Reeder博士的儿科内分泌学导师颁发K23职业发展奖，并将为胰岛素抵抗和青春期腹部脂肪异位沉积提供令人兴奋的新科学见解。

DESCRIPTION (provided by applicant): This is a new submission for a K24 mid-career investigator award in patient-oriented research to support the mentoring, research and career development activities of Dr. Scott Reeder. Dr. Reeder is an Associate Professor at the University of Wisconsin-Madison, with a primary appointment in Radiology and cross- appointments in the Departments of Medicine, Medical Physics, and Biomedical Engineering. After his arrival at UW-Madison in 2005, Dr. Reeder founded a patient-oriented research program for the development and translation of advanced MRI methods into clinical practice. He leads the UW Liver Imaging Research Program, an active NIDDK-funded group developing and validating advanced MRI methods for improved diagnosis of abdominal diseases. The group is focused on validation of quantitative MRI biomarkers of diffuse liver disease, including methods to quantify abdominal adiposity and liver fat, liver iron overload, and non-invasive methods to evaluate the hemodynamics of the liver in patients with portal hypertension. Dr. Reeder has played a major mentoring role at UW-Madison as the Director of the Clinical MRI fellowship for the past 8 years and in his new role as Associate Director of the UW MD/PhD program. He has mentored a large number of medical students, residents, clinical fellows, graduate students, post-doctoral fellows and visiting professors in a wide variety of patient-oriented imaging projects. Most of these projects are interdisciplinary in focus and Dr. Reeder has built well-established collaborations with Pediatric Endocrinology, Emergency Medicine, Hepatology, Hematology, and Transplant Surgery, among others. Dr. Reeder is also the Medical Director of MRI at UW. His combined clinical and research leadership roles have enabled him to build a thriving mentoring environment for patient- oriented imaging research. Support from a K24 award would provide Dr. Reeder with the dedicated time needed to mentor clinicians performing patient-oriented research by freeing him from clinical and administrative responsibilities. Dr. Reeder will also continue his NIDDK funded R01 projects and participate in responsible conduct of research activities. He will also pursue a career development plan that includes additional training in liver disease and metabolic syndrome, as well as patient-centered outcomes research. Finally, he will perform a community-based patient-oriented research project examining the role of quantitative MRI biomarkers in the evolution of ectopic abdominal fat and insulin resistance during puberty in school-age girls. This interdisciplinary study will be performed as part of an ongoing mentorship-collaboration with a junior investigator in Pediatric Endocrinology. Given the outstanding environment at UW-Madison and this well- established mentoring relationship, this project is expected to lay the groundwork for future proposals including a K23 career development award for Dr. Reeder's mentee in Pediatric Endocrinology and will provide exciting new scientific insight into insulin resistance and ectopic abdominal fat deposition during puberty.