An Open Source Precision Medicine Platform for Cloud Operating Systems

适用于云操作系统的开源精准医疗平台

• 批准号: 9140741
• 负责人: Alexander Wait Zaranek
• 金额: $ 98.53万
• 依托单位: CUROVERSE, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-20 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9140741
• 关键词: Address; Adopted; Big Data; Bioinformatics; Businesses; Capital; Clinical; Clinical Decision Support Systems; Collaborations; Communities; Computer software; Contractor; DNA Sequence; DNA biosynthesis; Data; Data Set; Databases; Development; Distributed Systems; Ecosystem; Feedback; Fostering; Funding; Galaxy; Genome; Genomics; Grant; Health; Healthcare; Human; Industry; Information Technology; Institutional Policy; International; Internet; Language; Length; Letters; Machine Learning; Maintenance; Manuscripts; Measures; Medicine; Memory; Molecular; Operating System; Phase; Policies; Production; Publications; Reproducibility; Research; Research Infrastructure; Resources; Secure; Services; Small Business Innovation Research Grant; Source Code; System; Technology; Time; Training Support; Vision; Work; base; big biomedical data; cloud platform; commercialization; data management; genome sequencing; genomic data; health care delivery; individual patient; meetings; new technology; next generation sequencing; open source; operation; petabyte; portability; precision medicine; public health relevance; repository; screening; success; symposium; synthetic biology; terabyte; web services; whole genome

 DESCRIPTION (provided by applicant): Rapid improvements in DNA sequencing and synthesis have the potential to usher in a new era of precision medicine. To realize this vision, however, we must re-imagine the computational and storage infrastructure used to manage and extract actionable results from the massive data sets made possible by widely available advances in DNA sequencing and synthetic biology. In conjunction with the Global Alliance for Genomics and Health (GA4GH), we propose to build the Arvados platform so that a new ecosystem of clinical decision support applications will be able to navigate petabytes of global biomedical data and search millions of genomes in real-time (seconds). Our team has a proven track record of commercial success and high impact scientific research. Commercialization of this free and open-source software (FOSS) platform, which will be greatly accelerated by this grant, will permit organizations to seamlessly span on-premise & hosted cloud- operating systems and vastly simplify data-management & computation, all while facilitating compliance with institutional policies and regulatory requirements.

 描述（由适用提供）：DNA测序和合成的快速改进有可能引入精密医学的新时代。但是，要实现这一愿景，我们必须重新想象用于管理和提取可行的结果的计算和存储基础架构，从大规模的数据集中通过DNA测序和合成生物学中广泛可用的进步所获得的可行结果。结合全球基因组和健康联盟（GA4GH），我们建议建立Arvados平台，以便新的临床决策支持应用程序的新生态系统能够在全球生物医学数据的PBITES上进行导航，并实时搜索数百万个基因组（第二秒）。我们的团队拥有商业成功和高影响科学研究的良好记录。该赠款将大大加速该免费和开源软件（FOSS）平台的商业化，将使组织无缝地跨越本地和托管云操作系统，并大大简化数据管理和计算，同时支持遵守机构政策和监管要求。