An Open Source Precision Medicine Platform for Cloud Operating Systems

 描述（由申请人提供）：DNA测序和合成的快速改进有可能开创精准医学的新时代。然而，为了实现这一愿景，我们必须重新设想用于管理和从大量数据集中提取可操作结果的计算和存储基础设施，这些数据集是由DNA测序和合成生物学的广泛进步所实现的。与全球基因组学与健康联盟（GA4GH）合作，我们建议建立Arvados平台，以便临床决策支持应用程序的新生态系统能够导航PB级的全球生物医学数据并实时搜索数百万个基因组（秒）。我们的团队拥有商业成功和高影响力科学研究的良好记录。这一免费和开源软件（FOSS）平台的商业化将大大加快，这将使组织能够无缝跨越内部部署和托管云操作系统，并大大简化数据管理和计算，同时促进遵守机构政策和监管要求。

 DESCRIPTION (provided by applicant): Rapid improvements in DNA sequencing and synthesis have the potential to usher in a new era of precision medicine. To realize this vision, however, we must re-imagine the computational and storage infrastructure used to manage and extract actionable results from the massive data sets made possible by widely available advances in DNA sequencing and synthetic biology. In conjunction with the Global Alliance for Genomics and Health (GA4GH), we propose to build the Arvados platform so that a new ecosystem of clinical decision support applications will be able to navigate petabytes of global biomedical data and search millions of genomes in real-time (seconds). Our team has a proven track record of commercial success and high impact scientific research. Commercialization of this free and open-source software (FOSS) platform, which will be greatly accelerated by this grant, will permit organizations to seamlessly span on-premise & hosted cloud- operating systems and vastly simplify data-management & computation, all while facilitating compliance with institutional policies and regulatory requirements.