Primary Infection Resource Consortium (Pirc)

描述(由申请人提供)：圣地亚哥初级感染资源联盟(PIRC)R24申请提供了一个机会，使与识别和招募来自圣地亚哥社区的急性和早期艾滋病毒(AEH)感染者有关的卓有成效的合作研究持续16年以上。使用新的和不断发展的方法招募AEH患者，我们建立了广泛的基础设施和社区支持，每年使用双重护理点HIV快速检测(RT)筛查，并在所有RT阴性的人中进行HIV核酸检测(NAT)，对3,600名患者进行检测。预计的艾滋病毒筛查计划将确保每年识别和招募45名AEH患者、40名慢性艾滋病毒(C-HIV)患者、40名AEH参与者(包括传播者和非传播者)的性伴侣(SP)，以及120名反复暴露、未感染艾滋病毒(EU-HIV)的人。VVE建议从这些参与者那里收集、处理、冷冻存储并提供各种生物标本(取决于艾滋病毒感染的阶段)，包括血浆、外周血单核细胞(PBMC)、生殖器分泌物、直肠拭子和口腔液。我们还记录了与参与者及其存储的标本相关的大量人口统计、行为和风险数据。PIRC建议通过对符合条件的联盟调查人员提交的概念表研究提案进行多机构审查，提供对存档和预期资源的访问。为了提供对带丰富注释的数据和样本的访问，并使预期的基础、转换、流行病学和模型研究成为可能，PIRC将致力于以下具体目标：1)项目监督和研究访问PIRC；2)确定、登记和保留一个具有圣地亚哥HLV疫情代表并适合准确推断传播动力学的队列；3)从PIRC参与者那里收集临床和行为信息以及生物样本；4)提供集成、灵活和可访问的数据管理和信息技术指导和支持；以及5)提供统计和网络建模专业知识。PIRC将提供一个复杂的在线数据存储和检索系统，为财团调查人员提交概念表和获取数据提供便利。 相关性：圣地亚哥初级感染资源联盟(PIRC)将提供广泛的临床和行为数据、生物材料、开源软件工具以及高质量和低成本效益的服务。收集的数据的广度将为联盟调查人员评估与艾滋病毒传播、预防、耐药性、双重感染和根除有关的紧迫问题提供一个重要机会。

DESCRIPTION (provided by applicant): The San Diego Primary Infection Resource Consortium (PIRC) R24 application represents an opportunity to sustain more than 16 years of remarkably productive collaborative research related to the identification and recruitment of persons with acute and early HIV (AEH) infection from the San Diego community. Using novel and evolving methods to recruit persons with AEH, we have established extensive infrastructure and community support to test 3,600 individuals annually using dual point-of-care HIV rapid test (RT) screening, paired with HIV nucleic acid testing (NAT) in all RT negative persons. The projected HIV screening program will ensure the identification and recruitment of 45 AEH, 40 chronic HIV (C-HIV), 40 sexual partners (SP) of participants with AEH (both transmitting and non-transmitting) and 120 repeatedly-exposed, HIV uninfected (EU-HIV) individuals each year. From these participants, vve propose to collect, process, cryostore, and make available a variety of biological specimens (depending on stage of HIV infection), including blood plasma, peripheral blood mononuclear cells (PBMC), genital secretions, rectal swabs, and oral fluid. We also record extensive demographic, behavioral, and risk data that are linked to participants and their stored specimens. The PIRC proposes to offer access to both archived and prospective resources using a multi- institutional review of concept sheet research proposals submitted by eligible consortium investigators. In order to provide access to richly annotated data and specimens and to enable prospective basic, translational, epidemiologic, and modeling research, the PIRC will address the following Specific Aims: 1) Program oversight and research access to PIRC; 2) Identify, enroll, and retain a cohort representative of the San Diego HlV epidemic and suitable for accurate inference of transmission dynamics; 3) Collect clinical and behavioral information, and biological samples from piRC participants; 4) Provide integrated, flexible and accessible data management and information technology guidance and support; and 5) Provide statistical and network modeling expertise. The PIRC will provide a sophisticated online data storage and retrieval system that will facilitate concept sheet submission and data access for consortium investigators. RELEVANCE: The San Diego Primary Infection Resource Consortium (PIRC) will provide extensive clinical and behavioral data, biological materials, open source software tools, and services that are of high quality and cost-efficient. The breadth of the collected data will represent a significant opportunity for consortium investigators to evaluate pressing issues related to HIV transmission, prevention, resistance, superinfection, and eradication.