Primary Infection Resource Consortium (Pirc)

圣地亚哥原发感染资源联盟（PIRC）R24应用程序代表了一个机会，以维持超过16年的显着生产力的合作研究有关的识别和招募人员与急性和早期艾滋病毒（AEH）感染从圣地亚哥社区。使用新的和不断发展的方法招募AEH患者，我们建立了广泛的基础设施和社区支持，每年使用双重护理点HIV快速检测（RT）筛查对3，600人进行检测，并在所有RT阴性人群中进行HIV核酸检测（NAT）。预计的艾滋病毒筛查计划将确保每年识别和招募45名AEH，40名慢性艾滋病毒（C-HIV），40名AEH参与者的性伴侣（SP）（包括传播和非传播）和120名反复暴露的艾滋病毒未感染者（EU-HIV）。从这些参与者中，vve建议收集，处理，冷冻保存和提供各种生物标本（取决于HIV感染的阶段），包括血浆，外周血单核细胞（PBMC），生殖器分泌物，直肠拭子和口腔液。我们还记录了与参与者及其存储标本相关的广泛的人口统计学，行为和风险数据。PIRC建议通过对合格的联盟调查人员提交的概念表研究提案进行多机构审查，提供对存档和预期资源的访问。为了提供对丰富注释的数据和标本的访问，并使前瞻性基础、转化、流行病学和建模研究成为可能，PIRC将致力于以下具体目标：1）对PIRC的计划监督和研究访问; 2）识别、登记和保留代表圣地亚哥HIV流行病并适合于传播动力学的准确推断的队列; 3）从piRC参与者收集临床和行为信息以及生物样本; 4）提供集成、灵活和可访问的数据管理和信息技术指导和支持;以及5）提供统计和网络建模专业知识。PIRC将提供一个先进的在线数据存储和检索系统，以方便联合体调查人员提交概念表和访问数据。 相关性：圣地亚哥原发性感染资源联盟（PIRC）将提供广泛的临床和行为数据，生物材料，开源软件工具和高质量和高成本效益的服务。收集的数据的广度将为联盟研究人员提供一个重要的机会，以评估与艾滋病毒传播，预防，耐药性，重复感染和根除有关的紧迫问题。

DESCRIPTION (provided by applicant): The San Diego Primary Infection Resource Consortium (PIRC) R24 application represents an opportunity to sustain more than 16 years of remarkably productive collaborative research related to the identification and recruitment of persons with acute and early HIV (AEH) infection from the San Diego community. Using novel and evolving methods to recruit persons with AEH, we have established extensive infrastructure and community support to test 3,600 individuals annually using dual point-of-care HIV rapid test (RT) screening, paired with HIV nucleic acid testing (NAT) in all RT negative persons. The projected HIV screening program will ensure the identification and recruitment of 45 AEH, 40 chronic HIV (C-HIV), 40 sexual partners (SP) of participants with AEH (both transmitting and non-transmitting) and 120 repeatedly-exposed, HIV uninfected (EU-HIV) individuals each year. From these participants, vve propose to collect, process, cryostore, and make available a variety of biological specimens (depending on stage of HIV infection), including blood plasma, peripheral blood mononuclear cells (PBMC), genital secretions, rectal swabs, and oral fluid. We also record extensive demographic, behavioral, and risk data that are linked to participants and their stored specimens. The PIRC proposes to offer access to both archived and prospective resources using a multi- institutional review of concept sheet research proposals submitted by eligible consortium investigators. In order to provide access to richly annotated data and specimens and to enable prospective basic, translational, epidemiologic, and modeling research, the PIRC will address the following Specific Aims: 1) Program oversight and research access to PIRC; 2) Identify, enroll, and retain a cohort representative of the San Diego HlV epidemic and suitable for accurate inference of transmission dynamics; 3) Collect clinical and behavioral information, and biological samples from piRC participants; 4) Provide integrated, flexible and accessible data management and information technology guidance and support; and 5) Provide statistical and network modeling expertise. The PIRC will provide a sophisticated online data storage and retrieval system that will facilitate concept sheet submission and data access for consortium investigators. RELEVANCE: The San Diego Primary Infection Resource Consortium (PIRC) will provide extensive clinical and behavioral data, biological materials, open source software tools, and services that are of high quality and cost-efficient. The breadth of the collected data will represent a significant opportunity for consortium investigators to evaluate pressing issues related to HIV transmission, prevention, resistance, superinfection, and eradication.