Predoctoral Program in Biophysics

描述（由申请人提供）：耶鲁大学生物物理培训计划（BTP）的目标是为博士前学员提供进行终生研究所需的实践技能和智力发展，这些研究对一系列重要的生物医学主题产生影响。这些主题植根于一组教师的兴趣，将化学系与分子生物物理学和生物化学系（MB&B）联系起来。我们的33名培训师加入了在分子水平上发展生物学见解的共同魅力，特别关注结构，能量和动力学。洞察力发展的环境范围从合成模型系统到整个动物研究，并发表了跨越这一范围的串扰。我们的学生受益于结构生物学，光学和磁性光谱学，物理化学，计算化学和低温电子显微镜的世界一流的专业知识。我们计划的结构和我们导师的技能在我们的学生严谨，独立和创造力中发展。我们渴望并成功地培养出敢于冒险的毕业生，他们推动生物物理学的前沿，成为各自领域的下一代领导者。生物物理学对生物医学研究的重要性已经增长，并变得越来越有活力。这是显而易见的，在耶鲁大学，特别是在这个建议，我们大大增加了教师导师谁也持有任命，例如，病理学，遗传学，药理学，物理学，机械和化学工程。MB&B部门的学员入学现在通过新成立的伞跨部门轨道，生物化学，生物物理学和结构生物学（BBSB）进行。这条赛道是在承认生物物理卓越的导师在许多部门之间的存在，并大大增加了我们的学生库伪造。该计划的两个部门的受训人员具有跨越生物学，生物化学，分子生物学，合成和物理化学，物理和数学的背景。学生在第一年完成课程要求，并进行三次实验室轮换。这些要求增加了资格考试，迫使学生独立定义一个研究项目，并口头辩护给教师小组。然后，论文由一个由三名教师导师组成的委员会进行监督，他们定期与实习生举行正式会议。我们建议支持我们的学生在他们的第二年和/或第三年的研究生院后，论文重点变得清晰。BTP确立了方案身份，并通过几条途径极大地促进了两个部门之间的互动。这包括共享的课程元素，轮换和联合活动，如每月的学生研究会谈，接待来访的知名演讲者和新成立的务虚会/研讨会。这些规定，加上培训人员强大的智力和物质资源，使BTP能够培养出世界级的毕业生。

DESCRIPTION (provided by applicant): The goal of the Biophysics Training Program (BTP) at Yale is to equip pre-doctoral trainees with the practical skills and intellectual development necessary to perform a lifetime of research with impact across a range of vital, biomedical topics. These topics are rooted in the interests of a set of faculty linking the Department of Chemistry and the Department of Molecular Biophysics and Biochemistry (MB&B). Our 33 trainers are joined by a shared fascination in developing biological insights at the molecular level with particular attention to structure, energy and dynamics. The milieus under which insights are developed range from synthetic model systems to whole animal studies with published cross talk that spans this range. Our students benefit from world-class expertise in structural biology, optical and magnetic spectroscopies, physical chemistry, computational chemistry and cryo-electron microscopy. The structure of our program and the skills of our Mentors develop in our students rigor, independence and creativity. We aspire and succeed in producing adventurous graduates who push at the frontiers of Biophysics to become the next generation of leaders in their fields. The importance of biophysics to biomedical research has grown and become increasingly dynamic. This is evident at Yale and specifically in this proposal by our greatly increased number of faculty mentors who also hold appointments in, for example, Pathology, Genetics, Pharmacology, Physics, Mechanical and Chemical Engineering. Admissions of trainees to the MB&B Department now take place through a newly formed umbrella cross-departmental track, the Biochemistry, Biophysics and Structural Biology (BBSB). This track was forged in recognition of the presence of Biophysical excellence among mentors in many departments and has greatly increased our student pool. The pool of trainees coming to the two departments of this program have backgrounds that span biology, biochemistry, molecular biology, synthetic and physical chemistry, physics and mathematics. Students fulfill curricular requirements in their first year and perform three lab rotations. These requirements are augmented with qualifying exams that compel a student to independently define a research project and defend it orally to a faculty panel. The dissertation is then given oversight by a committee of three faculty mentors who hold regular formal meetings with the trainee. We propose support for our students in their second and/or third year of graduate school after the dissertation focus becomes clear. The BTP establishes programmatic identity and greatly facilitates interactions between the two departments by several routes. This includes shared curriculum elements, rotations and joint activities such as monthly student research talks, hosting of visiting eminent speakers and a newly established retreat/symposium. These provisions, combined with the strong intellectual and material resources of the trainers, enable the BTP to produce world-class graduates.