Training Program in Translational Cardiovascular Research and Entrepreneurship

 描述(由申请者提供)：该提案寻求在密歇根大学开发一个新的转化性心血管研究和创业(CVRE)培训计划。心血管疾病是世界范围内主要的死亡原因。因此，该项目的使命是培训寻求心血管研究职业生涯的下一代博士科学家，从分子水平，通过细胞、完整的组织和动物模型，到床边，研究成果的伦理开发和应用，最终目标是改善患者的治疗。因为这是一名博士后 培训经历发生在博士项目的最后两年，经过初步审查，重点是高级教学计划和自主研究。拟议的培训计划旨在解决年轻基础科学家和博士前学生在转化性心血管研究关键领域的培训差距，这些领域包括临床前研究设计、药物发现、设备/治疗开发、优化和测试、企业家精神和法规遵从性。该项目的跨学科和国际公认的教师提供了一个出色的培训环境，其中包括最先进的设施和技术，涵盖了血管和心脏疾病的遗传、分子、细胞、系统、工程和临床研究。通过利用我们在基础和临床前心血管研究方面的现有教师优势和密歇根大学独特的学术资源，我们不仅将培训学生进行最先进的生物医学研究，还将培训学生将系统生物学应用于临床前测试、导航法规遵从性和企业家精神。因此，该项目为学生提供了独特的全面和身临其境的翻译研究培训体验。它的另一个好处是，它还将使学生为年轻科学家可以从事的、通常由他们追求的多样化的科学职业做好准备，包括学术研究、初创公司、生物技术以及大型制药和设备公司。翻译CVRE计划将吸引来自弗兰克尔心血管中心教职员工、医学院生物医学科学计划和工程学院的实验室的学生。通过将学生置于基础心血管研究、生物医学工程和心血管医学之间，我们希望更好地培养下一代博士科学家，使他们成为基础研究发现的“领导者和最好的”，并能够指导他们走向临床。(摘要结束)

 DESCRIPTION (provided by applicant): This proposal seeks to develop a new training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. Therefore, the mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the level of the molecule, through the cellular, intact tissue and animal models, to the bedside, with the ultimate goal of improving therapy for patients. Since this is a pre-doctoral training experience taking place during the last two years of the PhD program after preliminary examination, the emphasis is on an advanced didactic program and independent research. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic and preclinical cardiovascular research and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive experience in translational research training. The added benefit is that it will also prepare students for the diversity of scientific careers available to and typially pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The translational CVRE program will attract students from laboratories across the Frankel Cardiovascular Center faculty membership, the medical school wide Program in Biomedical Sciences, and the School of Engineering. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be the "leaders and best" at taking basic research discoveries and being capable of directing their path to the clinic. (End of Abstract)