Training Program in Translational Cardiovascular Research and Entrepreneurship

 描述（由申请人提供）：本提案旨在密歇根大学开发一个新的转化心血管研究和创业（CVRE）培训项目。心血管疾病是全球死亡的主要原因。因此，该计划的使命是培养下一代寻求心血管研究职业的博士科学家，从分子水平，通过细胞，完整组织和动物模型，到床边，最终目标是改善患者的治疗。因为这是一个博士预科 培训经验发生在博士课程的最后两年经过初步审查，重点是先进的教学计划和独立研究。拟议的培训计划旨在解决转化心血管研究关键领域（如临床前研究设计、药物发现、器械/疗法开发、优化和测试、创业精神和法规遵从性）年轻基础科学家和博士前学生培训方面的差距。该计划的跨学科和国际公认的教师提供了一个优秀的培训环境，包括最先进的设施和技术，涵盖血管和心脏疾病的遗传，分子，细胞，系统，工程和临床研究。通过利用我们的教师在基础和临床前心血管研究和独特的学术资源在密歇根大学的现有优势，我们将培养学生不仅在最先进的生物医学研究，而且在应用系统生物学的临床前测试，导航监管合规性，和创业精神。因此，该计划为学生提供了一个独特的综合性和沉浸式的经验，在翻译研究培训。额外的好处是，它还将为学生提供科学职业的多样性做好准备，这些职业通常由年轻科学家追求，包括学术研究，初创公司，生物技术以及大型制药和设备公司。翻译CVRE计划将吸引来自弗兰克尔心血管中心教职员工，医学院生物医学科学计划和工程学院实验室的学生。通过将学生置于基础心血管研究，生物医学工程和心血管医学之间的接口，我们希望更好地培养下一代博士科学家成为基础研究发现的“领导者和最佳”，并能够将他们的道路引导到临床。(End摘要）

 DESCRIPTION (provided by applicant): This proposal seeks to develop a new training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. Therefore, the mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the level of the molecule, through the cellular, intact tissue and animal models, to the bedside, with the ultimate goal of improving therapy for patients. Since this is a pre-doctoral training experience taking place during the last two years of the PhD program after preliminary examination, the emphasis is on an advanced didactic program and independent research. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic and preclinical cardiovascular research and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive experience in translational research training. The added benefit is that it will also prepare students for the diversity of scientific careers available to and typially pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The translational CVRE program will attract students from laboratories across the Frankel Cardiovascular Center faculty membership, the medical school wide Program in Biomedical Sciences, and the School of Engineering. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be the "leaders and best" at taking basic research discoveries and being capable of directing their path to the clinic. (End of Abstract)