BIOSTATISTICS AND BIOINFORMATICS SHARED RESOURCE

在以前的拨款申请中，正在开发的生物信息学共享资源已被整合到生物统计学中，成为生物统计学和生物信息学共享资源（BBISR）。有四个（全职）博士水平的教师生物统计学家，两个（兼职）生物信息学教师，和两个硕士水平的生物统计学家，BBISR工作人员合作，并与Winship研究人员在临床前，临床，实验室，流行病学和分子癌症调查的设计，进行和分析咨询。 BBISR采用服务支持模式，利用现有的埃默里大学范围内的专业知识和投资，以满足Winship成员的需求。具体而言，BBISR通过努力专业地完成以下研究部分来促进研究：设计（满足研究目标的可行性，样本量），有关关键基础设施的建议，数据分析，报告和手稿的准备，临床和转化研究委员会提案的审查，以及项目所需方法的开发。BBISR的总体目标是确保使用适当的研究 设计和适当的分析方法在Winship癌症成员的研究。BBISR的工作人员都在当地整合，在整个埃默里大学的温希普研究计划，包括公共卫生的罗林斯学院，综合信息学中心，并与亚特兰大临床和转化科学研究所。 与Winship研究人员的合作已经产生了51篇出版物，BBISR工作人员在CY2010中为38份资助申请做出了贡献。关于这一共享资源的未来计划包括： 通过与基因组数据的更大整合来加强早期试验设计中现有的生物统计学专业知识，通过招聘更多的教职员工来扩大生物统计学专业知识，培养生物信息学方面的核心人员，并采取措施建立专门的信息学支持。

The developing Bioinformatics Shared Resource in the previous grant submission has been integrated within biostatistics to become the Biostatistics and Bioinformatics Shared Resource (BBISR). With four (full-time) doctoral level faculty biostatisticians, two (part-time) bioinformatics faculty, and two master-level biostatisticians, BBISR staff members collaborate and consult with Winship investigators in the design, conduct, and analysis of preclinical, clinical, laboratory, epidemiologic and molecular cancer investigations. BBISR uses a service support model that draws upon existing Emory University-wide expertise and investment to meet the needs of Winship members. Specifically, BBISR facilitates research by striving to expertly fulfilling the following study components: design (feasibility in meeting study objectives, sample size), recommendations concerning key infrastructure, data analysis, preparations of reports and manuscripts, review of proposals in the Clinical and Translational Research Committee, and development of methods as needed by project. The overall goal of the BBISR is to ensure the use of proper study design and appropriate analysis methods in Winship cancer members' research. BBISR staff members are integrated both locally, within the Winship research programs throughout Emory University, including the Rollins School of Public Health, the Center for Comprehensive Informatics, and with the Atlanta Clinical and Translational Science Institute. Collaborations with Winship investigators have resulted in 51 publications, and BBISR staff members contributing to 38 grant submissions in CY2010. Future plans for this shared resource include the following: strengthening current biostatistics expertise in early phase trial design by a greater integration with genomic data, expanding biostatistics expertise through additional faculty and staff recruitment, building core personnel in bioinformatics, and initiatives towards building devoted informatics support.