Biostatistics and Bioinformatics Shared Resource

生物统计学和生物信息学共享资源 项目总结/摘要 Winship生物统计学和生物信息学共享资源（BBISR）提供以下服务和合作： 临床、实验室、人群和分子癌症研究设计和分析。BBISR由团队定义- 的方法来支持癌症研究人员，其中BBISR的教职员工是正确的， 获得准确的结果，同时意识到他们在这项癌症研究中的作用和最后期限， 他们的处决。BBISR的总体目标是为Winship的 基础、转化和临床研究。这是通过确保使用适当的研究设计来实现的 和分析方法的Winship成员为他们的研究项目。BBISR已经建立了一个用户友好的 在线服务请求系统，允许及时支持和跟踪SR利用率，并利用现有的 埃默里大学范围内的专业知识，以满足Winship成员的需求。它专门支持Winship研究人员 通过：设计试验，注意可行性，样本量和生物标志物分析;数据分析和 编写研究总结报告;协助编写统计学相关章节的手稿 设计和方法;以及审查Winship临床和转化研究委员会的建议 （CTRC）。BBISR的工作人员被整合在温希普的研究计划和整个埃默里大学 大学，包括罗林斯公共卫生学院。BBISR的工作人员和教职员工拥有强大的专业知识 在I期临床试验设计、回顾性研究设计和分析、临床生物信息学、途径和 网络分析、融合分析以及分子和癌症监测形式的“大数据”分析 数据BBISR支持了几个高影响力的出版物，并在所有团队科学项目中发挥了关键作用 在此资助期间在Winship进行的研究。BBISR支持Winship团队科学项目 包括头颈癌SPORE，一个肺癌项目申请（重新提交， 2016年9月），正在开发的肺癌孢子申请（将于2016年9月提交），以及 机构临床试验，包括I期研究。此外，BBISR成员进行的原创研究 在I期临床试验的设计和实施方面取得了重要的方法学进展。总的来说， 在此资助期间，BBISR支持了Winship项目的115名核心研究人员， 已资助了216份出版物和50份同行评审赠款。BBISR的利用率稳步增长 在目前的资助期内，Winship所有四个项目的成员和BBISR都处于有利地位， 支持Winship正在进行和计划中的研究项目。

BIOSTATISTICAL AND BIOINFORMATICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Winship Biostatistics and Bioinformatics Shared Resource (BBISR) offers services and collaboration in clinical, laboratory, population, and molecular cancer study design and analysis. BBISR is defined by a TEAM- based approach to support cancer investigators, in which BBISR faculty and staff are Thoughtfully Engaged to obtain Accurate results, while being Mindfully aware of their role in this cancer research and the deadlines for their execution. The overall goal of BBISR is to provide outstanding statistical and analytical support to Winship's basic, translational, and clinical research. This is accomplished by ensuring the use of appropriate study design and analytical methods by Winship members for their research projects. BBISR has established a user-friendly online service request system that allows for timely support and tracking of SR utilization, and leverages existing Emory University-wide expertise to meet Winship member needs. It supports Winship researchers specifically by: designing trials with attention to feasibility, sample size, and biomarker analysis; data analysis and preparation of study summary reports; assistance with manuscript preparation for sections relevant to statistical design and methods; and review of proposals in Winship's Clinical and Translational Research Committee (CTRC). BBISR staff members are integrated within Winship's research programs and throughout Emory University, including the Rollins School of Public Health. BBISR staff and faculty members have strong expertise in phase I clinical trial designs, retrospective study designs and analysis, clinical bioinformatics, pathways and network analysis, fusion analysis, and analysis of “Big Data” in the form of both molecular and cancer surveillance data. BBISR has supported several high-impact publications and played key roles in all the team-science projects that have been conducted at Winship during this funding period. BBISR supported Winship team science projects including the Head and Neck Cancer SPORE, a program project application for lung cancer (resubmission in September 2016), a developing Lung Cancer SPORE application (to be submitted in September 2016), and institutional clinical trials, including phase I studies. In addition, original research conducted by BBISR members have resulted in important methodological advances in the design and conduct of phase I clinical trials. Overall, BBISR supported 115 core investigators in Winship programs during this funding period, collaborations which have resulted in 216 publications and 50 peer-reviewed grants funded. Utilization of BBISR has grown steadily over the present funding period by membership of all four Winship programs and BBISR is well positioned to support Winship's ongoing and planned research projects.