Impact of retroviral infection on non-classical, mycobacteria-specific T cells.
Impact of retroviral infection on non-classical, mycobacteria-specific T cells.
批准号:
9204576
负责人:
Scott G Hansen
金额:
$22.48万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-01 至 2018-06-30
关键词:
Acquired Immunodeficiency SyndromeAffectAnimal ModelAnti-Bacterial AgentsAntitubercular AgentsAutopsyBacteriaBacterial InfectionsBindingCD8B1 geneCause of DeathCell surfaceCellsDataEpitopesFoundationsFrequenciesGenus MycobacteriumGoalsHIVHIV drug resistanceHistocompatibility Antigens Class IHumanImmune responseImmunityImmunologic Deficiency SyndromesImmunologic MonitoringIndividualInfectionInterventionLigandsLiverLocationLungLymphoidMacacaMacaca mulattaMapsMethodologyModelingMonitorMorbidity - disease rateMucosal ImmunityMucous MembraneMulti-Drug ResistanceMycobacterium tuberculosisNatural Killer CellsOpen Reading FramesOrganPeptidesPhenotypePhysiologicalPopulationPositioning AttributePropertyReagentRecording of previous eventsSIVScienceT cell responseT-Cell ImmunodeficiencyT-LymphocyteTestingTherapeuticTimeTissuesTuberculosisTuberculosis VaccinesVaccinatedVaccinesVirus Diseasesbaseco-infectiondesignhuman diseaseimmunogenicmortalitymycobacterialnonhuman primatenovelnovel vaccinesperipheral bloodpreventprotein aminoacid sequenceresponsetooltuberculosis immunityvaccination against tuberculosis
中文摘要
项目总结
英文摘要
Project Summary
Over 30 million people are currently infected with HIV, and over 2 million people die from AIDS each year.
These numbers are dwarfed only by the number of individuals infected with tuberculosis (TB). Approximately
two-thirds of the world's population is currently infected with the bacterium that causes TB, and approximately
10% of those individuals develop active TB. Individuals who are infected with both HIV and TB are up to 31
times more likely to develop tuberculosis than those with TB alone. Thus, there is an inherent need to
understand how HIV affects the immune response to TB and whether an intervention can be designed to
prevent tuberculosis in co-infected individuals. We have recently identified two unique populations of non-
classical CD8+ T cells in rhesus macaques that we believe are critical players in anti-mycobacterial immunity:
mucosal associated invariant T cells (MAITs), and MHC-E restricted CD8+ T cells. Thus, the goal of this
proposal is to characterize these unique T cells following BCG vaccination and understand how SIV infection
impacts their anatomical distribution and function.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Project 2: Characterization of the in vivo T cell (and overall immune) interception of primary SIV infection after vaccination with differentially response programmed RhCMV/SIV vectors
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批准号:10709017
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项目类别:
-
资助金额:$55.93万
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财政年份:2022
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负责人:Scott G Hansen
-
依托单位:
Project 2: Characterization of the in vivo T cell (and overall immune) interception of primary SIV infection after vaccination with differentially response programmed RhCMV/SIV vectors
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批准号:10619303
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项目类别:
-
资助金额:$75.55万
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财政年份:2022
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负责人:Scott G Hansen
-
依托单位:
Understanding Unconventional CD8+ T cell Responses in Protection from HIV
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批准号:9623141
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项目类别:
-
资助金额:$84.72万
-
财政年份:2018
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负责人:Scott G Hansen
-
依托单位:
Understanding Unconventional CD8+ T cell Responses in Protection from HIV
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批准号:10398872
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项目类别:
-
资助金额:$79.59万
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财政年份:2018
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负责人:Scott G Hansen
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依托单位:
Efficacy of Strain 68-1 RhCMV Vectors Expressing 5' Leader Polypeptides
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批准号:9266296
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项目类别:
-
资助金额:$85.62万
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财政年份:2016
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负责人:Scott G Hansen
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依托单位:
Growth of rheusus cytomegalovirus in macrophages
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批准号:6694843
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项目类别:
-
资助金额:$4.64万
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财政年份:2003
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负责人:Scott G Hansen
-
依托单位:
Growth of rheusus cytomegalovirus in macrophages
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批准号:6794113
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项目类别:
-
资助金额:$4.89万
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财政年份:2003
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负责人:Scott G Hansen
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依托单位:
海外基金