Impact of retroviral infection on non-classical, mycobacteria-specific T cells.

项目摘要 目前有3000多万人感染艾滋病毒，每年有200多万人死于艾滋病。 与感染结核病(TB)的人数相比，这些数字相形见绌。大致 目前世界上三分之二的人口感染了导致结核病的细菌，大约 这些人中有10%会患上活动性结核病。同时感染艾滋病毒和结核病的人数高达31岁 患肺结核的可能性是单独患有结核病的人的三倍。因此，存在一种内在的需要，即 了解艾滋病毒如何影响对结核病的免疫反应，以及是否可以设计干预措施来 预防合并感染的人患结核病。我们最近发现了两个独特的非 猕猴体内经典的CD8+T细胞，我们认为它们在抗分枝杆菌免疫中起着关键作用： 粘膜相关不变T细胞(MAITs)和MHC-E限制性CD8+T细胞。因此，这一目标是 建议是在接种卡介苗后表征这些独特的T细胞，并了解SIV感染 影响它们的解剖分布和功能。

Project Summary Over 30 million people are currently infected with HIV, and over 2 million people die from AIDS each year. These numbers are dwarfed only by the number of individuals infected with tuberculosis (TB). Approximately two-thirds of the world's population is currently infected with the bacterium that causes TB, and approximately 10% of those individuals develop active TB. Individuals who are infected with both HIV and TB are up to 31 times more likely to develop tuberculosis than those with TB alone. Thus, there is an inherent need to understand how HIV affects the immune response to TB and whether an intervention can be designed to prevent tuberculosis in co-infected individuals. We have recently identified two unique populations of non- classical CD8+ T cells in rhesus macaques that we believe are critical players in anti-mycobacterial immunity: mucosal associated invariant T cells (MAITs), and MHC-E restricted CD8+ T cells. Thus, the goal of this proposal is to characterize these unique T cells following BCG vaccination and understand how SIV infection impacts their anatomical distribution and function.